Longitudinal DNA methylation in parent-infant pairs impacted by intergenerational social adversity: An RCT of the Michigan Model of Infant Mental Health Home Visiting.
Humans
Female
Infant
DNA Methylation
Male
Adult
Brain-Derived Neurotrophic Factor
/ genetics
Infant, Newborn
House Calls
Parenting
/ psychology
Michigan
Adverse Childhood Experiences
Child, Preschool
Saliva
Mothers
/ psychology
Long Interspersed Nucleotide Elements
/ genetics
Psychotherapy
/ methods
Longitudinal Studies
Parent-Child Relations
Epigenesis, Genetic
Serotonin Plasma Membrane Transport Proteins
DNA methylation
Infant Mental Health
RCT trial
early life adversity
epigenetics
parent–child psychotherapy
Journal
Brain and behavior
ISSN: 2162-3279
Titre abrégé: Brain Behav
Pays: United States
ID NLM: 101570837
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
revised:
26
06
2024
received:
08
01
2024
accepted:
03
08
2024
medline:
19
9
2024
pubmed:
19
9
2024
entrez:
19
9
2024
Statut:
ppublish
Résumé
Early childhood development is a strong predictor of long-term health outcomes, potentially mediated via epigenetics (DNA methylation). The aim of the current study was to examine how childhood experiences, punitive parenting, and an intergenerational psychotherapeutic intervention may impact DNA methylation in young children and their mothers. Mothers and their infants/toddlers between 0 and 24 months were recruited at baseline (n = 146, 73 pairs) to participate in a randomized control trial evaluating the effectiveness of The Michigan Model of Infant Mental Health Home Visiting (IMH-HV) parent-infant psychotherapy compared to treatment as usual. Baseline and 12-month post-enrollment data were collected in the family's home and included self-report questionnaires, biological saliva samples, home environment observation, video-taped parent-child interaction, and audio-recorded interviews. Saliva DNA methylation was measured at the genes, nuclear receptor subfamily 3 group C member 1 (NR3C1), solute carrier family 6 member 4 (SLC6A4), brain-derived neurotrophic factor (BDNF), and the genetic element, long interspersed nuclear element-1 (LINE1). For mothers, baseline methylation of BDNF, SLC6A4, NR3C1, or LINE1 was largely not associated with baseline measures of their childhood adversity, adverse life experiences, demographic characteristics related to structurally driven inequities, or to IMH-HV treatment effect. In infants, there were suggestions that methylation in SLC6A4 and LINE1 was associated with parenting attitudes. Infant BDNF methylation suggested an overall decrease in response to IMH-HV psychotherapy over 12 months. Overall, our findings suggest that the epigenome in infants and young children may be sensitive to both early life experiences and parent-infant psychotherapy.
Substances chimiques
Brain-Derived Neurotrophic Factor
0
SLC6A4 protein, human
0
BDNF protein, human
7171WSG8A2
Serotonin Plasma Membrane Transport Proteins
0
Types de publication
Journal Article
Randomized Controlled Trial
Langues
eng
Sous-ensembles de citation
IM
Pagination
e70035Subventions
Organisme : Michigan Health Endowment Fund
Organisme : Michigan Department of Health and Human Services
Organisme : NIEHS NIH HHS
ID : P30ES017885
Pays : United States
Organisme : NIEHS NIH HHS
ID : T32ES007062
Pays : United States
Organisme : University of Michigan Department of Psychiatry's Women and Infants Mental Health Program
Organisme : Michigan Department of Health and Human Services Community Mental Health Services Block Grant
Informations de copyright
© 2024 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.
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