Scarring Alopecia in Tumor Necrosis Factor-α Antagonists-Induced Scalp Psoriasis.
TNFα inhibitor
alopecia
psoriasis
scalp
scarring
Journal
Journal of psoriasis and psoriatic arthritis
ISSN: 2475-5311
Titre abrégé: J Psoriasis Psoriatic Arthritis
Pays: United States
ID NLM: 101695066
Informations de publication
Date de publication:
Jul 2023
Jul 2023
Historique:
medline:
1
7
2023
pubmed:
1
7
2023
entrez:
19
9
2024
Statut:
ppublish
Résumé
A broad spectrum of adverse reactions associated with the use of tumor necrosis factor alpha (TNFα) antagonists has been recognized over the past years. Induction of scalp psoriasis is a less known undesirable consequence of the use of these drugs and is not well characterized. To characterize TNFα inhibitors-induced psoriatic alopecia. We studied 6 patients with TNF-inhibitor induced psoriatic alopecia and reviewed 28 patients with this condition reported in the literature to date. In addition to severe scalp psoriasis, we report hair follicle pathologies ranging from alopecia areata to scarring alopecia. Prognosis was good, but discontinuation of TNFα inhibitors was required in more than half of the cases in order to achieve a favourable outcome. TNFα inhibitors-associated psoriatic alopecia is rarely reported but requires a high index of suspicion and prompt diagnosis, as timely intervention may prevent irreversible damage.
Sections du résumé
Background
UNASSIGNED
A broad spectrum of adverse reactions associated with the use of tumor necrosis factor alpha (TNFα) antagonists has been recognized over the past years. Induction of scalp psoriasis is a less known undesirable consequence of the use of these drugs and is not well characterized.
Objective
UNASSIGNED
To characterize TNFα inhibitors-induced psoriatic alopecia.
Methods
UNASSIGNED
We studied 6 patients with TNF-inhibitor induced psoriatic alopecia and reviewed 28 patients with this condition reported in the literature to date.
Results
UNASSIGNED
In addition to severe scalp psoriasis, we report hair follicle pathologies ranging from alopecia areata to scarring alopecia. Prognosis was good, but discontinuation of TNFα inhibitors was required in more than half of the cases in order to achieve a favourable outcome.
Conclusion
UNASSIGNED
TNFα inhibitors-associated psoriatic alopecia is rarely reported but requires a high index of suspicion and prompt diagnosis, as timely intervention may prevent irreversible damage.
Identifiants
pubmed: 39296311
doi: 10.1177/24755303231173376
pii: 10.1177_24755303231173376
pmc: PMC11361512
doi:
Types de publication
Journal Article
Langues
eng
Pagination
90-95Informations de copyright
© The Author(s) 2023.
Déclaration de conflit d'intérêts
The author(s) declared the following potential conflicts of interest with respect to the research, authorship, and/or publication of this article: RDG has received research support and consulting fees from Janssen, Abbvie, Sanofi, Novartis, Pfizer; EZ has received research support and consulting fees from Janssen, Abbvie, Takeda, Neopharm, Celgene and Pfizer; MP has received research support from Pfizer.