The novel herbicide icafolin-methyl is a plant-specific inhibitor of tubulin polymerization.
icafolin
icafolin‐methyl
mode of action
plant‐specific tubulin polymerization inhibitor
post‐emergence herbicide
Journal
Pest management science
ISSN: 1526-4998
Titre abrégé: Pest Manag Sci
Pays: England
ID NLM: 100898744
Informations de publication
Date de publication:
19 Sep 2024
19 Sep 2024
Historique:
revised:
07
08
2024
received:
21
06
2024
accepted:
01
09
2024
medline:
22
9
2024
pubmed:
22
9
2024
entrez:
19
9
2024
Statut:
aheadofprint
Résumé
Without controlling weeds, it is estimated that about one third of global crop yields would be lost. Herbicides remain the most effective solution for weed control, but they face multiple challenges, such as the emergence and growth of resistant weed populations. Consequently, there is an urgent need for either herbicides with new modes of action or at least novel chemistries within established modes of action, with outstanding efficacy but without showing cross-resistance to the herbicides present in the prospective markets. Icafolin-methyl is a novel herbicide with a unique biological profile. It is hydrolyzed in planta to the carboxylic acid icafolin. After post-emergence application icafolin-methyl and icafolin both show high efficacy against the most relevant competitive weeds in cold and warm season cropping systems at low application rates, including resistant black-grass and rye-grass biotypes. Biochemical and genetic evidence is provided that icafolin-methyl and icafolin inhibit plant tubulin polymerization probably by binding to ß-tubulins. Icafolin-methyl is a novel non-selective herbicide with an established mode of action, but with a superior potency and spectrum, specifically after foliar application. This makes icafolin-methyl fundamentally different from existing tubulin polymerization inhibiting herbicides. It complements the farmers weed control toolbox, particularly with respect to resistance management. © 2024 Society of Chemical Industry.
Sections du résumé
BACKGROUND
BACKGROUND
Without controlling weeds, it is estimated that about one third of global crop yields would be lost. Herbicides remain the most effective solution for weed control, but they face multiple challenges, such as the emergence and growth of resistant weed populations. Consequently, there is an urgent need for either herbicides with new modes of action or at least novel chemistries within established modes of action, with outstanding efficacy but without showing cross-resistance to the herbicides present in the prospective markets.
RESULTS
RESULTS
Icafolin-methyl is a novel herbicide with a unique biological profile. It is hydrolyzed in planta to the carboxylic acid icafolin. After post-emergence application icafolin-methyl and icafolin both show high efficacy against the most relevant competitive weeds in cold and warm season cropping systems at low application rates, including resistant black-grass and rye-grass biotypes. Biochemical and genetic evidence is provided that icafolin-methyl and icafolin inhibit plant tubulin polymerization probably by binding to ß-tubulins.
CONCLUSION
CONCLUSIONS
Icafolin-methyl is a novel non-selective herbicide with an established mode of action, but with a superior potency and spectrum, specifically after foliar application. This makes icafolin-methyl fundamentally different from existing tubulin polymerization inhibiting herbicides. It complements the farmers weed control toolbox, particularly with respect to resistance management. © 2024 Society of Chemical Industry.
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024 Society of Chemical Industry.
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