Clinical bioinformatics desiderata for molecular tumor boards.
biobanking
clinical bioinformatics
clinical informatics
data engineering
decision support tools
molecular tumor board
molecular tumor registry
variant actionability
variant annotation
Journal
Briefings in bioinformatics
ISSN: 1477-4054
Titre abrégé: Brief Bioinform
Pays: England
ID NLM: 100912837
Informations de publication
Date de publication:
25 Jul 2024
25 Jul 2024
Historique:
received:
18
12
2023
revised:
28
06
2024
accepted:
30
08
2024
medline:
22
9
2024
pubmed:
22
9
2024
entrez:
19
9
2024
Statut:
ppublish
Résumé
Clinical Bioinformatics is a knowledge framework required to interpret data of medical interest via computational methods. This area became of dramatic importance in precision oncology, fueled by cancer genomic profiling: most definitions of Molecular Tumor Boards require the presence of bioinformaticians. However, all available literature remained rather vague on what are the specific needs in terms of digital tools and expertise to tackle and interpret genomics data to assign novel targeted or biomarker-driven targeted therapies to cancer patients. To fill this gap, in this article, we present a catalog of software families and human skills required for the tumor board bioinformatician, with specific examples of real-world applications associated with each element presented.
Identifiants
pubmed: 39297878
pii: 7761956
doi: 10.1093/bib/bbae447
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Italian Ministry of Health
ID : J47G22000300001
Organisme : European Union
Organisme : Italian NRRP
ID : IR0000031
Informations de copyright
© The Author(s) 2024. Published by Oxford University Press.