Autoantigens of Small Nerve Fibers and Human Coronavirus Antigens: Is There a Possibility for Molecular Mimicry?
Journal
Current microbiology
ISSN: 1432-0991
Titre abrégé: Curr Microbiol
Pays: United States
ID NLM: 7808448
Informations de publication
Date de publication:
19 Sep 2024
19 Sep 2024
Historique:
received:
16
10
2023
accepted:
05
09
2024
medline:
20
9
2024
pubmed:
20
9
2024
entrez:
19
9
2024
Statut:
epublish
Résumé
In post-COVID-19 syndrome, clinical presentation of the nerve fiber dysfunction plays an important role. The possibility of autoantigen cross-mimicry of human coronaviruses and the peripheral nervous system needs to be investigated. The bioinformatic analysis was applied to search for possible common protein sequences located in the immunoreactive epitopes. Among the autoantigens of the human nervous system, fibroblast growth factor receptor protein 3, myelin protein P0, myelin protein P2, sodium channel protein type 9, alpha protein subunit, plexin-D1 protein and ubiquitin-carboxyl-terminal hydrolase protein of the L1 isoenzyme were selected. The original "Alignmentaj" analytical program was created. The UniProt database, Protein Data Bank, and AlphaFold databases were used. The analysis of protein sequence similarities of spike glycoproteins in human coronaviruses revealed common pentapeptides of the MERS-CoV-2 virus with the fibroblast growth factor receptor 3 and myelin protein P2. Among seasonal coronaviruses, common peptide sequences were identified in HCoV-HKU-1 virus with sodium channel protein type 9 subunit alpha and Plexin-D1, HCoV-OC43 with Plexin-D1, as well as HCoV-NL63 with Plexin-D1 and Ubiquitin carboxyl-terminal hydrolase isozyme L1. Some shared peptides belong to immunoreactive epitopes. The most important targets for the molecular similarities are the sodium channel subunits and fibroblast growth factor receptor 3, both for seasonal and highly pathogenic coronaviruses. The data obtained make it possible to identify new potential targets for the development of autoimmune reactions that may occur against the background of the infections with highly pathogenic as well as seasonal coronaviruses.
Identifiants
pubmed: 39297982
doi: 10.1007/s00284-024-03885-5
pii: 10.1007/s00284-024-03885-5
doi:
Substances chimiques
Autoantigens
0
Antigens, Viral
0
Spike Glycoprotein, Coronavirus
0
Epitopes
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
366Subventions
Organisme : Russian Science Foundation of the Russian Academy of Sciences
ID : 22-15-00113
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Références
Spiteri G, Fielding J, Diercke M et al (2020) First cases of coronavirus disease 2019 (COVID-19) in the WHO European Region, 24 January to 21 February 2020. Euro Surveill 25:2000178. https://doi.org/10.2807/1560-7917.ES.2020.25.9.2000178
doi: 10.2807/1560-7917.ES.2020.25.9.2000178
pubmed: 32156327
pmcid: 7068164
Huang C, Wang Y, Li X et al (2020) Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China [published correction appears in Lancet. 2020 Jan 30;]. Lancet 395:497–506. https://doi.org/10.1016/S0140-6736(20)30183-5
doi: 10.1016/S0140-6736(20)30183-5
pubmed: 31986264
pmcid: 7159299
Lu R, Zhao X, Li J et al (2020) Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet 395:565–574. https://doi.org/10.1016/S0140-6736(20)30251-8
doi: 10.1016/S0140-6736(20)30251-8
pubmed: 32007145
pmcid: 7159086
Liu Y, Sawalha AH, Lu Q (2021) COVID-19 and autoimmune diseases. Curr Opin Rheumatol 33:155. https://doi.org/10.1097/BOR.0000000000000776
doi: 10.1097/BOR.0000000000000776
pubmed: 33332890
Churilov LP, Normatov MG, Utekhin VJ (2022) Molecular mimicry between SARS-CoV-2 and human endocrinocytes: a prerequisite of post-COVID-19 endocrine autoimmunity? Pathophysiology 29:486–494. https://doi.org/10.3390/pathophysiology29030039
doi: 10.3390/pathophysiology29030039
pubmed: 36136066
pmcid: 9504401
Vojdani A, Vojdani E, Kharrazian D (2021) Reaction of human monoclonal antibodies to SARS-CoV-2 proteins with tissue antigens: implications for autoimmune diseases. Front Immunol 11:3679. https://doi.org/10.3389/fimmu.2020.617089
doi: 10.3389/fimmu.2020.617089
Normatov MG, Karev VE, Kolobov AV et al (2023) Post-COVID endocrine disorders: putative role of molecular mimicry and some pathomorphological correlates. Diagnostics 13:522. https://doi.org/10.3390/diagnostics13030522
doi: 10.3390/diagnostics13030522
pubmed: 36766627
pmcid: 9914255
Al-Ramadan A, Rabab’h O, Shah J, Gharaibeh A (2021) Acute and post-acute neurological complications of COVID-19. Neurol Int 13:102–119. https://doi.org/10.3390/neurolint13010010
doi: 10.3390/neurolint13010010
pubmed: 33803475
pmcid: 8006051
Halpert G, Shoenfeld Y (2020) SARS-CoV-2, the autoimmune virus. Autoimmun Rev 19:102695. https://doi.org/10.1016/j.autrev.2020.102695
doi: 10.1016/j.autrev.2020.102695
pubmed: 33130000
pmcid: 7598743
Tomar BS, Singh M, Nathiya D et al (2021) Prevalence of symptoms in patients discharged from COVID care facility of NIMS hospital: is RT PCR negativity truly reflecting recovery? A single-centre observational study. Int J Gen Med 14:1069–1078. https://doi.org/10.2147/IJGM.S295499
doi: 10.2147/IJGM.S295499
pubmed: 33790636
pmcid: 8006813
Soldan SS, Lieberman PM (2023) Epstein-Barr virus and multiple sclerosis. Nat Rev Microbiol 21:51–64. https://doi.org/10.1038/s41579-022-00770-5
doi: 10.1038/s41579-022-00770-5
pubmed: 35931816
Laman JD, Huizinga R, Boons GJ, Jacobs BC (2022) Guillain-Barré syndrome: expanding the concept of molecular mimicry. Trends Immunol 43:296–308. https://doi.org/10.1016/j.it.2022.02.003
doi: 10.1016/j.it.2022.02.003
pubmed: 35256276
pmcid: 9016725
Kanduc D, Shoenfeld Y (2020) Molecular mimicry between SARS-CoV-2 spike glycoprotein and mammalian proteomes: implications for the vaccine. Immunol Res 68:310–313. https://doi.org/10.1007/s12026-020-09152-6
doi: 10.1007/s12026-020-09152-6
pubmed: 32946016
pmcid: 7499017
Kanduc D (2020) From Anti-SARS-CoV-2 immune responses to COVID-19 via molecular mimicry. Antibodies (Basel) 9:33. https://doi.org/10.3390/antib9030033
doi: 10.3390/antib9030033
pubmed: 32708525
Novak P (2020) Post COVID-19 syndrome associated with orthostatic cerebral hypoperfusion syndrome, small fiber neuropathy and benefit of immunotherapy: a case report. eNeurologicalSci 21:100276. https://doi.org/10.1016/j.ensci.2020.100276
doi: 10.1016/j.ensci.2020.100276
pubmed: 32984564
pmcid: 7502253
Koralnik IJ, Tyler KL (2020) COVID-19: a global threat to the nervous system. Ann Neurol 88:1–11. https://doi.org/10.1002/ana.25807
doi: 10.1002/ana.25807
pubmed: 32506549
pmcid: 7300753
Neumann B, Schmidbauer ML, Dimitriadis K et al (2020) Cerebrospinal fluid findings in COVID-19 patients with neurological symptoms. J Neurol Sci 418:117090. https://doi.org/10.1016/j.jns.2020.117090
doi: 10.1016/j.jns.2020.117090
pubmed: 32805440
pmcid: 7417278
Paterson RW, Brown RL, Benjamin L et al (2020) The emerging spectrum of COVID-19 neurology: clinical, radiological and laboratory findings. Brain 143:3104–3120. https://doi.org/10.1093/brain/awaa240
doi: 10.1093/brain/awaa240
pubmed: 32637987
pmcid: 7454352
Solomon IH, Normandin E, Bhattacharyya S et al (2020) Neuropathological features of covid-19. N Engl J Med 383:989–992. https://doi.org/10.1056/NEJMc2019373
doi: 10.1056/NEJMc2019373
pubmed: 32530583
Panagiotides NG, Zimprich F, Machold K, Schlager O, Müller M, Ertl S, Löffler-Stastka H, Koppensteiner R, Wadowski pp. (2023) A case of autoimmune small fiber neuropathy as possible post COVID sequelae. Int J Environ Res Public Health 20(6):4918. https://doi.org/10.3390/ijerph20064918
doi: 10.3390/ijerph20064918
pubmed: 36981826
pmcid: 10049708
Agnihotri SP, Luis CVS, Kazamel M (2022) Autonomic neuropathy as post-acute sequela of SARS-CoV-2 infection: a case report. J Neurovirol 28(1):158–161. https://doi.org/10.1007/s13365-022-01056-5
doi: 10.1007/s13365-022-01056-5
pubmed: 35181863
pmcid: 8856878
Abrams RMC, Simpson DM, Navis A, Jette N, Zhou L, Shin SC (2022) Small fiber neuropathy associated with SARS-CoV-2 infection. Muscle Nerve 65(4):440–443. https://doi.org/10.1002/mus.27458
doi: 10.1002/mus.27458
pubmed: 34766365
Azcue N, Del Pino R, Acera M, Fernández-Valle T, Ayo-Mentxakatorre N, Pérez-Concha T, Murueta-Goyena A, Lafuente JV, Prada A, López de Munain A, Ruiz Irastorza G, Martín-Iglesias D, Ribacoba L, Gabilondo I, Gómez-Esteban JC, Tijero-Merino B (2023) Dysautonomia and small fiber neuropathy in post-COVID condition and chronic fatigue syndrome. J Transl Med 21(1):814. https://doi.org/10.1186/s12967-023-04678-3
doi: 10.1186/s12967-023-04678-3
pubmed: 37968647
pmcid: 10648633
Mastropaolo M, Hasbani MJ (2023) Small fiber neuropathy triggered by COVID-19 vaccination: association with FGFR3 autoantibodies and improvement during intravenous immunoglobulin treatment. Case Rep Neurol 15(1):6–10. https://doi.org/10.1159/000528566
doi: 10.1159/000528566
pubmed: 36742446
pmcid: 9891845
Schwartz B, Moudgil S, Pollina F, Bhargava A (2023) Small fiber neuropathy after SARS-CoV-2 infection and vaccination: a case-based comparison. Cureus 15(8):e43600. https://doi.org/10.7759/cureus.43600
doi: 10.7759/cureus.43600
pubmed: 37719518
pmcid: 10504057
UniProt Consortium (2019) UniProt: a worldwide hub of protein knowledge. Nucleic Acids Res 47(D1):D506–D515. https://doi.org/10.1093/nar/gky1049
doi: 10.1093/nar/gky1049
Berman HM, Westbrook J, Feng Z et al (2000) The protein data bank. Nucleic Acids Res 28:235–242. https://doi.org/10.1093/nar/28.1.235
doi: 10.1093/nar/28.1.235
pubmed: 10592235
pmcid: 102472
Varadi M, Anyango S, Deshpande M et al (2022) AlphaFold protein structure database: massively expanding the structural coverage of protein-sequence space with high-accuracy models. Nucleic Acids Res 50:D439–D444. https://doi.org/10.1093/nar/gkab1061
doi: 10.1093/nar/gkab1061
pubmed: 34791371
Schrödinger L The PyMOL molecular graphics system, version 2.5.4
Vita R, Mahajan S, Overton JA et al (2019) The immune epitope database (IEDB): 2018 update. Nucleic Acids Res 47:D339–D343. https://doi.org/10.1093/nar/gky1006
doi: 10.1093/nar/gky1006
pubmed: 30357391
Hallgren J, Tsirigos KD, Pedersen MD, Almagro A et al (2022) DeepTMHMM predicts alpha and beta transmembrane proteins using deep neural networks. BioRxiv. https://doi.org/10.1101/2022.04.08.487609
doi: 10.1101/2022.04.08.487609
Hasan ZN, Zalzala HH, Mohammedsalih HR et al (2014) Association between human leukocyte antigen-DR and demylinating Guillain-Barre syndrome. Neurosci J 19:301–305
Gigli GL, Vogrig A, Nilo A et al (2020) HLA and immunological features of SARS-CoV-2-induced Guillain-Barré syndrome. Neurol Sci 41:3391–3394
doi: 10.1007/s10072-020-04787-7
pubmed: 33006723
pmcid: 7530349
Nilsson JB, Kaabinejadian S, Yari H et al (2023) Accurate prediction of HLA class II antigen presentation across all loci using tailored data acquisition and refined machine learning. Sci Adv 9:eadj6367
doi: 10.1126/sciadv.adj6367
pubmed: 38000035
pmcid: 10672173
Kim JE, Heo JH, Kim HO et al (2017) Neurological complications during treatment of middle east respiratory syndrome. J Clin Neurol 13(3):227–233. https://doi.org/10.3988/jcn.2017.13.3.227
doi: 10.3988/jcn.2017.13.3.227
pubmed: 28748673
pmcid: 5532318
Gupta A, Jayakumar MN, Saleh MA et al (2022) SARS-CoV-2 infection—induced growth factors play differential roles in COVID-19 pathogenesis. Life Sci 304:120703. https://doi.org/10.1016/j.lfs.2022.120703
doi: 10.1016/j.lfs.2022.120703
pubmed: 35700841
pmcid: 9188443
Trevino JA, Novak P (2021) TS-HDS and FGFR3 antibodies in small fiber neuropathy and Dysautonomia. Muscle Nerve 64:70–76. https://doi.org/10.1002/mus.27245
doi: 10.1002/mus.27245
pubmed: 33792960
Nagarajan E, Kang SA, Holmes C, Govindarajan R (2021) Clinical features with anti fibroblast growth factor receptor 3 (FGFR3) antibody-related polyneuropathy: a retrospective study. BMC Neurol 21:74. https://doi.org/10.1186/s12883-021-02090-2
doi: 10.1186/s12883-021-02090-2
pubmed: 33588772
pmcid: 7883452
Bayraktutar BN, Atocha V, Farhad K, Soto O, Hamrah P (2023) Autoantibodies against trisulfated heparin disaccharide and fibroblast growth factor receptor-3 may play a role in the pathogenesis of neuropathic corneal pain. Cornea 42:821–828. https://doi.org/10.1097/ICO.0000000000003142
doi: 10.1097/ICO.0000000000003142
pubmed: 36256257
Zeidman LA, Saini P, Mai P (2022) Immune-mediated small fiber neuropathy with trisulfated heparin disaccharide, fibroblast growth factor receptor 3, or Plexin D1 antibodies: presentation and treatment with intravenous immunoglobulin. J Clin Neuromuscul Dis 24:26–37. https://doi.org/10.1097/CND.0000000000000423
doi: 10.1097/CND.0000000000000423
pubmed: 36005471
Holl EK, O’Connor BP, Holl TM et al (2011) Plexin-D1 is a novel regulator of germinal centers and humoral immune responses. J Immunol 186:5603–5611. https://doi.org/10.4049/jimmunol.1003464
doi: 10.4049/jimmunol.1003464
pubmed: 21464091
Fujii T, Yamasaki R, Iinuma K et al (2018) A novel autoantibody against Plexin D1 in patients with neuropathic pain. Ann Neurol 84:208–224. https://doi.org/10.1002/ana.25279
doi: 10.1002/ana.25279
pubmed: 30014510
Kelley MA, Oaklander AL (2020) Association of small-fiber polyneuropathy with three previously unassociated rare missense SCN9A variants. Can J Pain 4:19–29. https://doi.org/10.1080/24740527.2020.1712652
doi: 10.1080/24740527.2020.1712652
pubmed: 32719824
pmcid: 7384751
Hisama FM, Dib-Hajj SD, Waxman SG. SCN9A neuropathic pain syndromes. In: Adam MP, Mirzaa GM, Pagon RA, et al., eds. GeneReviews®. Seattle (WA): University of Washington, Seattle; May 6, 2006
Amaya F, Wang H, Costigan M et al (2006) The voltage-gated sodium channel Na(v)1.9 is an effector of peripheral inflammatory pain hypersensitivity. J Neurosci 26:12852–12860. https://doi.org/10.1523/JNEUROSCI.4015-06.2006
doi: 10.1523/JNEUROSCI.4015-06.2006
pubmed: 17167076
pmcid: 6674969
Matuszczak E, Tylicka M, Komarowska MD, Debek W, Hermanowicz A (2020) Ubiquitin carboxy-terminal hydrolase L1—physiology and pathology. Cell Biochem Funct 38:533–540. https://doi.org/10.1002/cbf.3527
doi: 10.1002/cbf.3527
pubmed: 32207552
Boucher A, Desforges M, Duquette P, Talbot PJ (2007) Long-term human coronavirus-myelin cross-reactive T-cell clones derived from multiple sclerosis patients. Clin Immunol 123(3):258–267. https://doi.org/10.1016/j.clim.2007.02.002
doi: 10.1016/j.clim.2007.02.002
pubmed: 17448727
pmcid: 7106099
Desforges M, Le Coupanec A, Dubeau P et al (2019) Human coronaviruses and other respiratory viruses: underestimated opportunistic pathogens of the central nervous system? Viruses 12:14. https://doi.org/10.3390/v12010014
doi: 10.3390/v12010014
pubmed: 31861926
pmcid: 7020001
Teodorescu DL, Kote A, Reaso JN et al (2024) Postural orthostatic tachycardia syndrome after COVID-19 vaccination. Heart Rhythm 21(1):74–81. https://doi.org/10.1016/j.hrthm.2023.09.012
doi: 10.1016/j.hrthm.2023.09.012
pubmed: 38176772
Bernheimer JH, Pan B, Gerecke BJ (2023) Small-fiber neuropathy after vaccination with mRNA-1273 SARS-CoV-2 vaccine. J Clin Neuromuscul Dis 24(3):169–170. https://doi.org/10.1097/CND.0000000000000432
doi: 10.1097/CND.0000000000000432
pubmed: 36809210
pmcid: 9943741