Germline mutations in a G protein identify signaling cross-talk in T cells.

Humans Germ-Line Mutation T-Lymphocytes / immunology Signal Transduction Receptors, Antigen, T-Cell / metabolism Proto-Oncogene Proteins c-akt / metabolism Cell Movement MAP Kinase Signaling System Cell Proliferation ras Proteins / metabolism Phosphatidylinositol 3-Kinases / metabolism

Journal

Science (New York, N.Y.)
ISSN: 1095-9203
Titre abrégé: Science
Pays: United States
ID NLM: 0404511

Informations de publication

Date de publication:
20 Sep 2024
Historique:
medline: 20 9 2024
pubmed: 20 9 2024
entrez: 19 9 2024
Statut: ppublish

Résumé

Humans with monogenic inborn errors responsible for extreme disease phenotypes can reveal essential physiological pathways. We investigated germline mutations in

Identifiants

DOI: 10.1126/science.add8947 PMID: 39298586
pubmed: 39298586
doi: 10.1126/science.add8947
doi:

Substances chimiques

Receptors, Antigen, T-Cell 0
Proto-Oncogene Proteins c-akt EC 2.7.11.1
ras Proteins EC 3.6.5.2
Phosphatidylinositol 3-Kinases EC 2.7.1.-

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadd8947

Auteurs

Hyoungjun Ham (H)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0002-8669-6875

Huie Jing (H)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0001-6283-3452

Ian T Lamborn (IT)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0009-0006-1490-3667

Megan M Kober (MM)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0003-3909-9573

Alexey Koval (A)

Department of Cell Physiology and Metabolism, Faculty of Medicine, Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
ORCID: 0000-0002-8920-4426

Yamina A Berchiche (YA)

Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, USA.

D Eric Anderson (DE)

Advanced Mass Spectrometry Facility, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD, USA.
ORCID: 0000-0002-6838-0201

Kirk M Druey (KM)

Lung and Vascular Inflammation Section, Laboratory of Allergic Diseases, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0002-5834-6501

Judith N Mandl (JN)

Lymphocyte Biology Section, Laboratory of Immune System Biology, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0002-6512-3437

Bertrand Isidor (B)

Service de Génétique Médicale, CHU Nantes, Nantes Université, Nantes, France.
L'Institut du Thorax, CHU Nantes, INSERM UMR 1087/CNRS UMR 6291, Nantes Université, Nantes, France.
ORCID: 0000-0001-6480-126X

Carlos R Ferreira (CR)

Skeletal Genomics Unit, Metabolic Medicine Branch, DIR, National Human Genome Research Institute (NHGRI), NIH, Bethesda, MD, USA.
ORCID: 0000-0002-2697-1046

Alexandra F Freeman (AF)

Laboratory of Clinical Immunology and Microbiology, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0001-7005-8345

Sundar Ganesan (S)

Biological Imaging Section, Research Technologies Branch, DIR, NIAID, NIH, Bethesda, MD 20892, USA.

Meliha Karsak (M)

Neuronal and Cellular Signal Transduction, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-6612-6317

Peter J Mustillo (PJ)

Nationwide Children's Hospital, Columbus, OH, USA.
The Ohio State University College of Medicine, Columbus, OH, USA.
ORCID: 0000-0002-8420-8655

Juliana Teo (J)

Department of Haematology, The Children's Hospital Westmead, Sydney, New South Wales, Australia.
ORCID: 0000-0002-2895-0214

Zarazuela Zolkipli-Cunningham (Z)

Mitochondrial Medicine Frontier Program, Division of Human Genetics, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Department of Pediatrics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Nicolas Chatron (N)

Service de Génétique, Hospices Civils de Lyon, Lyon, France.
Institut NeuroMyoGène, Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261, INSERM U1315, Université Claude Bernard Lyon 1, Lyon, France.
ORCID: 0000-0003-0538-0981

François Lecoquierre (F)

Université de Rouen Normandie, INSERM U12045 and CHU Rouen, Department of Genetics and Reference Center for Developmental Disorders, FHU-G4 Génomique, Rouen, France.
ORCID: 0000-0002-9110-1856

Andrew J Oler (AJ)

Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0002-6310-0434

Jana Pachlopnik Schmid (JP)

Division of Immunology, University Children's Hospital Zurich, Zurich, Switzerland.
Pediatric Immunology, University of Zurich, Zurich, Switzerland.
ORCID: 0000-0002-6653-9047

Douglas B Kuhns (DB)

Neutrophil Monitoring Lab, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.
ORCID: 0000-0002-9971-0760

Xuehua Xu (X)

Chemotaxis Signal Section, Laboratory of Immunogenetics, DIR, NIAID, NIH, Rockville, MD, USA.
ORCID: 0000-0002-3863-9593

Fabian Hauck (F)

Division of Pediatric Immunology and Rheumatology, Department of Pediatrics, Dr. von Hauner Children's Hospital, University Hospital, Ludwig-Maximilians-Universität (LMU), Munich, Germany.
ORCID: 0000-0001-9644-2003

Waleed Al-Herz (W)

Department of Pediatrics, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait.
Department of Pediatrics, Al-Sabah Hospital, Kuwait City, Kuwait.
ORCID: 0000-0003-4244-4489

Matias Wagner (M)

Institute of Human Genetics, Technical University Munich, School of Medicine and Health, Munich, Germany.
Institute of Neurogenomics, Helmholtz Zentrum München, Neuherberg, Germany.
Department of Pediatrics, Division of Pediatric Neurology, Developmental Medicine and Social Pediatrics, University Hospital of Munich, Munich, Germany.
ORCID: 0000-0002-4454-8823

Paulien A Terhal (PA)

Division of Laboratories, Pharmacy and Biomedical Genetics, University Medical Centre Utrecht, Utrecht, The Netherlands.
ORCID: 0000-0002-4417-4307

Mari Muurinen (M)

Folkhälsan Research Center, Genetics Research Program, Helsinki, Finland.
Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
ORCID: 0009-0008-5595-4334

Vincent Barlogis (V)

APHM, La Timone Children's Hospital, Department of Pediatric Hematology, Immunology, and Oncology, Marseille, France.
Aix-Marseille University, EA 3279 Research Unit, Marseille, France.
ORCID: 0000-0001-9645-3968

Phillip Cruz (P)

Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID, NIH, Bethesda, MD, USA.

Jeffrey Danielson (J)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.

Helen Stewart (H)

Oxford Centre for Genomic Medicine, Nuffield Orthopaedic Centre, Oxford University Hospitals, NHS Foundation Trust, Headington, Oxford, UK.

Petra Loid (P)

Folkhälsan Research Center, Genetics Research Program, Helsinki, Finland.
Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-2708-0878

Sebastian Rading (S)

Neuronal and Cellular Signal Transduction, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Boris Keren (B)

Genetic Departement, Assistance Publique - Hôpitaux de Paris.Sorbonne University, Paris, France.
SeqOIA Laboratory, FMG2025, Paris, France.
ORCID: 0000-0001-6172-8247

Rolph Pfundt (R)

Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, Netherlands.
ORCID: 0000-0002-0584-4398

Kol A Zarember (KA)

Laboratory of Clinical Immunology and Microbiology, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0002-9624-7096

Katharina Vill (K)

LMU University Hospital, Department of Pediatrics, Division of Pediatric Neurology, iSPZ Hauner MUC - Munich University Center for Children with Medical and Developmental Complexity, Dr. von Hauner Children's Hospital, Munich, Germany.
ORCID: 0000-0003-1925-7538

Lorraine Potocki (L)

Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA.
Texas Children's Hospital, Houston, TX, USA.

Kenneth N Olivier (KN)

Pulmonary Branch, Division of Intramural Research, DIR, National Heart Lung and Blood Institute (NHLBI), NIH, Bethesda, MD, USA.
ORCID: 0000-0001-8200-255X

Gaetan Lesca (G)

Service de Génétique, Hospices Civils de Lyon, Lyon, France.
Institut NeuroMyoGène, Physiopathologie et Génétique du Neurone et du Muscle, CNRS UMR 5261, INSERM U1315, Université Claude Bernard Lyon 1, Lyon, France.
ORCID: 0000-0001-7691-9492

Laurence Faivre (L)

Génétique des Anomalies du Développement (GAD), UMR 1231, INSERM, Université Bourgogne-Franche Comté, Dijon, France.
Centre de Génétique et Centre de Référence "Anomalies du Développement et Syndromes Malformatifs de l'Inter-région Est", FHU TRANSLAD, CHU Dijon Bourgogne, Dijon, France.
ORCID: 0000-0001-9770-444X

Melanie Wong (M)

Department of Allergy and Immunology, The Children's Hospital at Westmead, Sydney, NSW, Australia.

Anne Puel (A)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, INSERM U1163, Paris, France.
Imagine Institute, University of Paris Cité, Paris, France.
ORCID: 0000-0003-2603-0323

Janet Chou (J)

Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
ORCID: 0000-0002-4610-2657

Maud Tusseau (M)

Genetics Department, Lyon University Hospital, Lyon, France.
The International Center of Research in Infectiology, Lyon University, INSERM U1111, CNRS UMR 5308, ENS, UCBL, Lyon, France.

Niki M Moutsopoulos (NM)

Oral Immunity and Infection Section, DIR, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Bethesda, MD, USA.
ORCID: 0000-0002-7365-6735

Helen F Matthews (HF)

Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
Molecular Development of the Immune System Section, Laboratory of Immune System Biology, DIR, NIAID, NIH, Bethesda, MD, USA.

Cas Simons (C)

Centre for Population Genomics, Garvan Institute of Medical Research and UNSW Sydney, Sydney, NSW, Australia.
Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
ORCID: 0000-0003-3147-8042

Ryan J Taft (RJ)

Institute for Molecular Bioscience, University of Queensland, St. Lucia, Queensland, Australia.
Illumina, San Diego, CA, USA.

Ariane Soldatos (A)

National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD, USA.
ORCID: 0000-0003-3570-5230

Etienne Masle-Farquhar (E)

Immunogenomics Laboratory, Garvan Institute of Medical Research, Sydney, NSW, Australia.
School of Clinical Medicine, UNSW Sydney, Sydney, NSW, Australia.
ORCID: 0000-0001-9355-8027

Stefania Pittaluga (S)

Laboratory of Pathology, Center for Cancer Research, NCI, NIH, Bethesda, MD, USA.
ORCID: 0000-0001-7688-1439

Robert Brink (R)

St. Vincent's Clinical School, UNSW, Sydney, NSW, Australia.
B Cell Biology Laboratory, Garvan Institute of Medical Research, Sydney, NSW, Australia.
ORCID: 0000-0002-9586-3655

Danielle L Fink (DL)

Neutrophil Monitoring Lab, Applied/Developmental Research Directorate, Frederick National Laboratory for Cancer Research, Frederick, MD, USA.

Heidi H Kong (HH)

Cutaneous Microbiome and Inflammation Section, Dermatology Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), NIH, Bethesda, MD, USA.
ORCID: 0000-0003-4424-064X

Juraj Kabat (J)

Biological Imaging Section, Research Technologies Branch, DIR, NIAID, NIH, Bethesda, MD 20892, USA.
ORCID: 0000-0001-8636-542X

Woo Sung Kim (WS)

Chemotaxis Signal Section, Laboratory of Immunogenetics, DIR, NIAID, NIH, Rockville, MD, USA.

Tatjana Bierhals (T)

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0002-6103-105X

Kazuyuki Meguro (K)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.

Amy P Hsu (AP)

Laboratory of Clinical Immunology and Microbiology, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0001-6841-2122

Jingwen Gu (J)

Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0003-2258-3131

Jennifer Stoddard (J)

Immunology Service, Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD, USA.

Benito Banos-Pinero (B)

Oxford Genetics Laboratories, Oxford University Hospitals NHS Foundation Trust, Oxford, Oxfordshire, UK.

Maria Slack (M)

Division of Allergy and Immunology, Department of Pediatrics, University of Rochester Medical Center and Golisano Children's Hospital, Rochester, NY, USA.

Giampaolo Trivellin (G)

Section on Endocrinology and Genetics (SEGEN), DIR, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, USA.
ORCID: 0000-0003-2384-4153

Benoît Mazel (B)

Centre de Génétique et Centre de Référence "Anomalies du Développement et Syndromes Malformatifs de l'Inter-région Est", FHU TRANSLAD, CHU Dijon Bourgogne, Dijon, France.
Centre de Référence Déficiences Intellectuelles de Causes Rares, CHU Dijon Bourgogne, Dijon, France.
ORCID: 0000-0002-1788-1495

Maarja Soomann (M)

Division of Immunology, University Children's Hospital Zurich, Zurich, Switzerland.
ORCID: 0000-0002-2237-5327

Samuel Li (S)

Bioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology (OCICB), NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0002-8020-8367

Val J Watts (VJ)

Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN, USA.
ORCID: 0000-0003-1581-2936

Constantine A Stratakis (CA)

Section on Endocrinology and Genetics (SEGEN), DIR, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), NIH, Bethesda, MD, USA.
ORCID: 0000-0002-4058-5520

Maria F Rodriguez-Quevedo (MF)

Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.
ORCID: 0009-0001-8668-5113

Ange-Line Bruel (AL)

Génétique des Anomalies du Développement (GAD), UMR 1231, INSERM, Université Bourgogne-Franche Comté, Dijon, France.
Unité Fonctionnelle Innovation en Diagnostic Génomique des Maladies Rares, FHU TRANSLAD, CHU Dijon Bourgogne, Dijon, France.
ORCID: 0000-0002-0526-465X

Marita Lipsanen-Nyman (M)

Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
ORCID: 0000-0003-4959-2310

Paul Saultier (P)

APHM, La Timone Children's Hospital, Department of Pediatric Hematology, Immunology, and Oncology, Marseille, France.
Aix-Marseille University, INSERM, National Research Institute for Agriculture, Food and Environment (INRAe), Cardiovascular and Nutrition Research Center (C2VN), Marseille, France.
ORCID: 0000-0002-6327-0898

Rashmi Jain (R)

Clinical Immunology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Daphne Lehalle (D)

AP-HP Sorbonne Université, UF de Génétique Clinique, Centre de Référence Maladies Rares des Anomalies du Développement et Syndromes Malformatifs, Hôpital Trousseau, Paris, France.
ORCID: 0000-0002-2193-8685

Daniel Torres (D)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0003-1256-5829

Kathleen E Sullivan (KE)

Division of Allergy and Immunology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

Sébastien Barbarot (S)

Department of Dermatology, CHU Nantes, INRAE, UMR 1280, PhAN, Nantes Université, Nantes, France.
ORCID: 0000-0002-6629-9100

Axel Neu (A)

Department of Pediatrics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID: 0000-0001-7045-7194

Yannis Duffourd (Y)

Génétique des Anomalies du Développement (GAD), UMR 1231, INSERM, Université Bourgogne-Franche Comté, Dijon, France.
Unité Fonctionnelle Innovation en Diagnostic Génomique des Maladies Rares, FHU TRANSLAD, CHU Dijon Bourgogne, Dijon, France.

Morgan Similuk (M)

Centralized Sequencing Program, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0002-0403-2689

Kirsty McWalter (K)

GeneDx, Gaithersburg, MD, USA.
ORCID: 0000-0002-1654-9036

Pierre Blanc (P)

SeqOIA Laboratory, FMG2025, Paris, France.
ORCID: 0009-0003-8965-7171

Stéphane Bézieau (S)

Service de Génétique Médicale, CHU Nantes, Nantes Université, Nantes, France.
L'Institut du Thorax, CHU Nantes, INSERM UMR 1087/CNRS UMR 6291, Nantes Université, Nantes, France.
ORCID: 0000-0003-0095-1319

Tian Jin (T)

Chemotaxis Signal Section, Laboratory of Immunogenetics, DIR, NIAID, NIH, Rockville, MD, USA.

Raif S Geha (RS)

Division of Immunology, Boston Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, United States.
ORCID: 0000-0001-8262-9686

Jean-Laurent Casanova (JL)

St. Giles Laboratory of Human Genetics of Infectious Diseases, Rockefeller Branch, The Rockefeller University, New York, NY, USA.
Laboratory of Human Genetics of Infectious Diseases, Necker Branch, Institut National de la Santé et de la Recherche Médicale, INSERM U1163, Paris, France.
Imagine Institute, University of Paris Cité, Paris, France.
Howard Hughes Medical Institute, New York, NY, USA.
Department of Pediatrics, Necker Hospital for Sick Children, Paris, France.
ORCID: 0000-0002-7782-4169

Outi M Makitie (OM)

Folkhälsan Research Center, Genetics Research Program, Helsinki, Finland.
Children's Hospital, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Research Program for Clinical and Molecular Metabolism, University of Helsinki, Helsinki, Finland.
ORCID: 0000-0002-4547-001X

Christian Kubisch (C)

Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Martin Zeitz Center for Rare Diseases, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.

Patrick Edery (P)

Service de Génétique, Hospices Civils de Lyon, Lyon, France.
Centre de Recherche en Neurosciences de Lyon, Inserm U1028, UMR CNRS 5292, Université Claude Bernard Lyon 1, Lyon, France.
ORCID: 0000-0001-8976-5832

John Christodoulou (J)

Murdoch Children's Research Institute, Melbourne, Victoria, Australia.
Department of Paediatrics, University of Melbourne, Melbourne, Australia.
Specialty of Child and Adolescent Health, University of Sydney, Sydney, Australia.
ORCID: 0000-0002-8431-0641

Ronald N Germain (RN)

Lymphocyte Biology Section, Laboratory of Immune System Biology, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0003-1495-9143

Christopher C Goodnow (CC)

Immunogenomics Laboratory, Garvan Institute of Medical Research, Sydney, NSW, Australia.
Cellular Genomics Futures Institute, Sydney, NSW, Australia.
ORCID: 0000-0001-5296-6155

Thomas P Sakmar (TP)

Laboratory of Chemical Biology and Signal Transduction, The Rockefeller University, New York, NY, USA.
Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Center for Alzheimer Research, Division of Neurogeriatrics, Stockholm, Sweden.
ORCID: 0000-0002-2836-8953

Daniel D Billadeau (DD)

Division of Oncology Research, Schulze Center for Novel Therapeutics, Mayo Clinic, Rochester, MN, USA.
ORCID: 0000-0002-2296-9547

Sébastien Küry (S)

Service de Génétique Médicale, CHU Nantes, Nantes Université, Nantes, France.
L'Institut du Thorax, CHU Nantes, INSERM UMR 1087/CNRS UMR 6291, Nantes Université, Nantes, France.
ORCID: 0000-0001-5497-0465

Vladimir L Katanaev (VL)

Department of Cell Physiology and Metabolism, Faculty of Medicine, Translational Research Center in Oncohaematology, University of Geneva, Geneva, Switzerland.
Institute of Life Sciences and Biomedicine, Far Eastern Federal University, Vladivostok, Russia.
ORCID: 0000-0002-7909-5617

Yu Zhang (Y)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0002-6904-0372

Michael J Lenardo (MJ)

Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Molecular Development of the Immune System Section, Laboratory of Immune System Biology, DIR, NIAID, NIH, Bethesda, MD, USA.
ORCID: 0000-0003-1584-468X

Helen C Su (HC)

Human Immunological Diseases Section, Laboratory of Clinical Immunology and Microbiology, Division of Intramural Research (DIR), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
Clinical Genomics Program, DIR, NIAID, NIH, Bethesda, MD, USA.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
ORCID: 0000-0002-5582-9110

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Germline mutations in a G protein identify...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mutation germinale › Germline mutations in a G protein identify...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Germline mutations in a G protein identify...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Germline mutations in a G protein identify...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux antigènes › Récepteurs aux antigènes des cellules T › Germline mutations in a G protein identify...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › Germline mutations in a G protein identify...
questionsmedicales.fr › Phénomènes physiologiques › Mouvement cellulaire › Germline mutations in a G protein identify...
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