Maintenance infusion rate of oxytocin after initial 1-IU bolus for elective Cesarean delivery: a dose-finding study.

Taux de perfusion d’ocytocine d’entretien après bolus initial de 1 UI pour l’accouchement par césarienne programmée : une étude de détermination de la dose.
Cesarean delivery maintenance infusion oxytocin

Journal

Canadian journal of anaesthesia = Journal canadien d'anesthesie
ISSN: 1496-8975
Titre abrégé: Can J Anaesth
Pays: United States
ID NLM: 8701709

Informations de publication

Date de publication:
19 Sep 2024
Historique:
received: 01 11 2023
accepted: 22 04 2024
revised: 22 04 2024
medline: 20 9 2024
pubmed: 20 9 2024
entrez: 19 9 2024
Statut: aheadofprint

Résumé

The purpose of our study was to determine the minimum effective dose of oxytocin maintenance infusion required to maintain adequate uterine tone in 90% of patients (ED We conducted a prospective, double-blind dose-finding study with biased coin up-down design. Immediately after delivery, a 1-IU oxytocin bolus was administered, followed by a maintenance infusion. The obstetrician assessed the uterine tone by palpation as satisfactory or unsatisfactory. In case of unsatisfactory response, the dose for the next patient was increased by 2 IU·hr We analyzed data for 40 patients. The ED Based on the results of this dose-finding study, we recommend a maintenance infusion rate of 4.5 IU·hr ClinicalTrials.gov ( NCT04946006 ); first submitted 25 June 2021. RéSUMé: OBJECTIF: L’objectif de notre étude était de déterminer la dose minimale efficace de perfusion d’entretien d’ocytocine nécessaire pour maintenir un tonus utérin adéquat chez 90 % des personnes parturientes (DE

Autres résumés

Type: Publisher (fre)
RéSUMé: OBJECTIF: L’objectif de notre étude était de déterminer la dose minimale efficace de perfusion d’entretien d’ocytocine nécessaire pour maintenir un tonus utérin adéquat chez 90 % des personnes parturientes (DE

Identifiants

DOI: 10.1007/s12630-024-02828-9 PMID: 39300008
pubmed: 39300008
doi: 10.1007/s12630-024-02828-9
pii: 10.1007/s12630-024-02828-9
doi:

Banques de données

ClinicalTrials.gov
['NCT04946006']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. Canadian Anesthesiologists' Society.

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Auteurs

Linda Boonstra (L)

Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Jose C A Carvalho (JCA)

Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.
Department of Obstetrics and Gynecology Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

William Turner (W)

Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Kristi Downey (K)

Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Xiang Y Ye (XY)

Department of Biostatistics, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Jackie Thomas (J)

Department of Obstetrics and Gynecology Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada.

Mrinalini Balki (M)

Department of Anesthesia and Pain Management, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. mrinalini.balki@uhn.ca.
Department of Obstetrics and Gynecology Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada. mrinalini.balki@uhn.ca.
Department of Physiology, University of Toronto, Toronto, ON, Canada. mrinalini.balki@uhn.ca.
Lunenfeld-Tanenbaum Research Institute, Sinai Health System, Toronto, ON, Canada. mrinalini.balki@uhn.ca.
Department of Anesthesiology and Pain Medicine, Mount Sinai Hospital, University of Toronto, 600 University Avenue, Room 7-405 to 409, Toronto, ON, M5G 1X5, Canada. mrinalini.balki@uhn.ca.
ORCID: 0000-0001-6568-021X

Classifications MeSH