A shared spatial topography links the functional connectome correlates of cocaine use disorder and dopamine D
Journal
Communications biology
ISSN: 2399-3642
Titre abrégé: Commun Biol
Pays: England
ID NLM: 101719179
Informations de publication
Date de publication:
19 Sep 2024
19 Sep 2024
Historique:
received:
03
01
2024
accepted:
03
09
2024
medline:
20
9
2024
pubmed:
20
9
2024
entrez:
19
9
2024
Statut:
epublish
Résumé
The biological mechanisms that contribute to cocaine and other substance use disorders involve an array of cortical and subcortical systems. Prior work on the development and maintenance of substance use has largely focused on cortico-striatal circuits, with relatively less attention on alterations within and across large-scale functional brain networks, and associated aspects of the dopamine system. Here, we characterize patterns of functional connectivity in cocaine use disorder and their spatial association with neurotransmitter receptor densities and transporter bindings assessed through PET. Profiles of functional connectivity in cocaine use disorder reliably linked with spatial densities of dopamine D
Identifiants
pubmed: 39300138
doi: 10.1038/s42003-024-06836-9
pii: 10.1038/s42003-024-06836-9
doi:
Substances chimiques
Receptors, Dopamine D2
0
Receptors, Dopamine D3
0
DRD2 protein, human
0
DRD3 protein, human
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1178Subventions
Organisme : U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH)
ID : R01MH120080
Informations de copyright
© 2024. The Author(s).
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