Clinical features and risk factors for recurrence of idiopathic pulmonary hemosiderosis in children.
Adolescent
Child
Child, Preschool
Female
Humans
Infant
Male
Adrenal Cortex Hormones
/ therapeutic use
Anemia
/ etiology
China
/ epidemiology
Cough
/ etiology
Hemoptysis
/ etiology
Hemosiderosis
/ complications
Hemosiderosis, Pulmonary
Lung Diseases
Recurrence
Respiratory Tract Infections
/ complications
Retrospective Studies
Risk Factors
Children
Clinical characteristics
Idiopathic pulmonary hemosiderosis
Risk factor
Journal
BMC pulmonary medicine
ISSN: 1471-2466
Titre abrégé: BMC Pulm Med
Pays: England
ID NLM: 100968563
Informations de publication
Date de publication:
19 Sep 2024
19 Sep 2024
Historique:
received:
11
02
2024
accepted:
03
09
2024
medline:
20
9
2024
pubmed:
20
9
2024
entrez:
19
9
2024
Statut:
epublish
Résumé
This study aims to review the clinical characteristics, therapeutic response and outcome of idiopathic pulmonary hemosiderosis (IPH), and discover the risk factors for recurrence in children with IPH, which will be helpful for the early diagnosis and reasonable treatment of this disease. Children with a diagnosis of IPH were enrolled in the study. Clinical data of the children were collected and analysed. A total of 32 patients with regular follow-up after diagnosis were included in this study. Anaemia, cough and haemoptysis constituted the most common initial symptoms of the disease, and the incidences were 90.6%, 75% and 56.2%, respectively. The mean gap between the onset of symptoms and diagnosis was 5 (0.25-36) months. Most of the children experienced remission (complete and partial remission) over the course of 6 months of treatment, but 19 of the children experienced relapse. The causes of disease recurrence included respiratory tract infection (37.5%), corticosteroid (CS) reduction (18.8%), and irregular medication (6.3%). Interestingly, we found that children with history of allergy (HR 4.255, 1.107-16.356) tended to experience disease recurrence (p = 0.01). Cough and anaemia are the most common symptoms in children with IPH. The recurrence rate of this disease is high, and respiratory tract infection is the most common cause of its recurrence. High-dose CS impluse therapy cannot reduce the recurrence rate of the disease. Allergic history was an import factor associated with disease recurrence. This study is a retrospective and observational study, which does not involve human specimens or clinical intervention. Therefore, clinical trial registration is not required, and there is no clinical trial number. However, the study was approved by the Institutional Review Board/Ethics Committee affiliated with West China Second University Hospital, Sichuan University (Ethics review number 2022074).
Sections du résumé
BACKGROUND
BACKGROUND
This study aims to review the clinical characteristics, therapeutic response and outcome of idiopathic pulmonary hemosiderosis (IPH), and discover the risk factors for recurrence in children with IPH, which will be helpful for the early diagnosis and reasonable treatment of this disease.
METHODS
METHODS
Children with a diagnosis of IPH were enrolled in the study. Clinical data of the children were collected and analysed.
RESULTS
RESULTS
A total of 32 patients with regular follow-up after diagnosis were included in this study. Anaemia, cough and haemoptysis constituted the most common initial symptoms of the disease, and the incidences were 90.6%, 75% and 56.2%, respectively. The mean gap between the onset of symptoms and diagnosis was 5 (0.25-36) months. Most of the children experienced remission (complete and partial remission) over the course of 6 months of treatment, but 19 of the children experienced relapse. The causes of disease recurrence included respiratory tract infection (37.5%), corticosteroid (CS) reduction (18.8%), and irregular medication (6.3%). Interestingly, we found that children with history of allergy (HR 4.255, 1.107-16.356) tended to experience disease recurrence (p = 0.01).
CONCLUSIONS
CONCLUSIONS
Cough and anaemia are the most common symptoms in children with IPH. The recurrence rate of this disease is high, and respiratory tract infection is the most common cause of its recurrence. High-dose CS impluse therapy cannot reduce the recurrence rate of the disease. Allergic history was an import factor associated with disease recurrence.
TRIAL REGISTRATION
BACKGROUND
This study is a retrospective and observational study, which does not involve human specimens or clinical intervention. Therefore, clinical trial registration is not required, and there is no clinical trial number. However, the study was approved by the Institutional Review Board/Ethics Committee affiliated with West China Second University Hospital, Sichuan University (Ethics review number 2022074).
Identifiants
pubmed: 39300433
doi: 10.1186/s12890-024-03267-4
pii: 10.1186/s12890-024-03267-4
doi:
Substances chimiques
Adrenal Cortex Hormones
0
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
461Subventions
Organisme : General Program of National Natural Science Foundation of China
ID : 82370001
Organisme : Fundamental Research Funds for the Central Universities
ID : SCU2022D022
Organisme : Development Fund for Clinical Discipline of West China Second Hospital of Sichuan University
ID : KL118
Informations de copyright
© 2024. The Author(s).
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