Association Between Vitamin D Insufficiency and Impaired Bone Density Among Adolescents With Perinatally Acquired HIV Infection.
HIV
adolescent
bone density
musculoskeletal health
vitamin d
Journal
Open forum infectious diseases
ISSN: 2328-8957
Titre abrégé: Open Forum Infect Dis
Pays: United States
ID NLM: 101637045
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
received:
13
03
2024
accepted:
29
07
2024
medline:
20
9
2024
pubmed:
20
9
2024
entrez:
20
9
2024
Statut:
epublish
Résumé
Stunting and pubertal delay are common among children growing up with human immunodeficiency virus (HIV) and are associated with bone and muscle impairments. We investigated factors associated with bone density and muscle function in adolescents living with HIV (ALWH). The VITALITY trial (PACTR202009897660297) investigated whether vitamin D and calcium supplementation improves musculoskeletal health among ALWH. A total of 842 ALWH aged 11-19 years, established on antiretroviral therapy (ART) for ≥6 months, were enrolled from HIV clinics in Zambia and Zimbabwe. Clinical history and examination were undertaken, and serum 25-hydroxyvitamin D TBLH-BMD Deficits in bone density are common in ALWH. Vitamin D and calcium supplementation and promotion of exercise may improve musculoskeletal health among perinatally infected ALWH.
Sections du résumé
Background
UNASSIGNED
Stunting and pubertal delay are common among children growing up with human immunodeficiency virus (HIV) and are associated with bone and muscle impairments. We investigated factors associated with bone density and muscle function in adolescents living with HIV (ALWH).
Methods
UNASSIGNED
The VITALITY trial (PACTR202009897660297) investigated whether vitamin D and calcium supplementation improves musculoskeletal health among ALWH. A total of 842 ALWH aged 11-19 years, established on antiretroviral therapy (ART) for ≥6 months, were enrolled from HIV clinics in Zambia and Zimbabwe. Clinical history and examination were undertaken, and serum 25-hydroxyvitamin D
Results
UNASSIGNED
TBLH-BMD
Conclusions
UNASSIGNED
Deficits in bone density are common in ALWH. Vitamin D and calcium supplementation and promotion of exercise may improve musculoskeletal health among perinatally infected ALWH.
Identifiants
pubmed: 39301108
doi: 10.1093/ofid/ofae442
pii: ofae442
pmc: PMC11411771
doi:
Types de publication
Journal Article
Langues
eng
Pagination
ofae442Investigateurs
Emily Carr
(E)
Matthias Hauptmann
(M)
Grace McHugh
(G)
Ester Gea-Mallorqui
(E)
Christoph Leschczyk
(C)
Tafadzwa Madanhire
(T)
Tadious Manyanga
(T)
Tsitsi S Mudzingwa
(TS)
Kudakwashe Mutasa
(K)
Cassandra Namukonda
(C)
N R Karen Sichibalo
(NRK)
Mizinga Tembo
(M)
Informations de copyright
© The Author(s) 2024. Published by Oxford University Press on behalf of Infectious Diseases Society of America.
Déclaration de conflit d'intérêts
Potential conflicts of interest. All authors: No reported conflicts.