Finite element analysis and

bone constructs bone tissue engineering cyclic loading durability endurance life fatigue strength

Journal

Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513

Informations de publication

Date de publication:
2024
Historique:
received: 14 04 2024
accepted: 27 08 2024
medline: 20 9 2024
pubmed: 20 9 2024
entrez: 20 9 2024
Statut: epublish

Résumé

Bone structures facilitate the regeneration and repair of bone tissue in regions where it has been damaged or destroyed, either temporarily or permanently. Therefore, the bone's fatigue strength and durability are crucial to its efficacy and longevity. Several variables, such as the construct's material qualities, design, and production procedure, loading and unloading cycles, and physiological conditions influence the endurance life of bone constructs. Metals, ceramics, and polymers are all routinely utilized to create bone substitutes, and each of these materials has unique features that might affect the fatigue strength and endurance life of the final product. The mechanical performance and capacity to promote bone tissue regeneration may be affected by the scaffold's design, porosity, and pore size. Researchers employ mechanical testing under cyclic loading circumstances as one example of an experimental approach used to assess bone construction endurance. These analyses can give us important information about the stress-strain behavior, resistance to multiple loading cycles, and fatigue strength of the new structure. Predicting the endurance life of the developed construct may also be possible with the use of simulations and numerical analyses. Hence, in order to create reliable and efficient constructs for bone tissue engineering, it is crucial to understand their fatigue strength and durability. The purpose of this study is to analyze the effective parameters for fatigue strength of bone structures and to gather the models and evaluations utilized in endurance life assessments.

Identifiants

pubmed: 39301173
doi: 10.3389/fbioe.2024.1417440
pii: 1417440
pmc: PMC11410606
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1417440

Informations de copyright

Copyright © 2024 Seraji, Nahavandi, Kia, Rabbani Doost, Keshavarz, Sharifianjazi, Tavamaishvili and Makarem.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Amir Abbas Seraji (AA)

Department of Mechanical and Industrial Engineering, University of Toronto, Toronto, ON, Canada.
Department of Polymer Engineering and Color Technology, Amirkabir University of Technology, Tehran, Iran.

Reza Nahavandi (R)

Department of Biochemical and Pharmaceutical Engineering, School of Chemical Engineering, College of Engineering, University of Tehran, Tehran, Iran.

Amir Kia (A)

Department of Mechanical Engineering, University of Guilan, Rasht, Iran.

Ahad Rabbani Doost (A)

Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, Iran.

Vahid Keshavarz (V)

Department of Materials Engineering, Faculty of Engineering and Technology, Imam Khomeini International University, Qazvin, Iran.

Fariborz Sharifianjazi (F)

Center for Advanced Materials and Structures, School of Science and Technology, The University of Georgia, Tbilisi, Georgia.

Ketevan Tavamaishvili (K)

School of Medicine, Georgian American University, Tbilisi, Georgia.

Dorna Makarem (D)

Escuela Tecnica Superior de Ingenieros de Telecomunicacion Politecnica de Madrid, Madrid, Spain.

Classifications MeSH