Usefulness of the Upright Posture Test in the Diagnosis of Primary Aldosteronism.

To assess the usefulness of the upright posture stimulation test (UPT) in the confirmation of primary aldosteronism (PA) in patients in whom saline tests (ST) were inconclusive. One hundred eighty-seven adult patients with possible PA were retrospectively included and compared to 25 control subjects. Blood samples were obtained after a 1-hour supine posture and during 2 hours of ambulation. An increase in plasma aldosterone concentration (PAC) ≥ 50% with a suppressed renin (≤10.1 ng/L; ≤1 ng/mL/hour) and a cortisol increase ≤50% were considered abnormal. PA patients had higher basal PAC and lower basal direct renin concentration (DRC) ( UPT can be useful to confirm PA, particularly in patients with suspected false-negative ST.

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© The Author(s) 2024. Published by Oxford University Press on behalf of the Endocrine Society.