Malignant salivary gland tumors of the tongue: A multicenter REFCOR study.

base of tongue carcinoma minor salivary gland oncologic outcomes tongue

Journal

International journal of cancer
ISSN: 1097-0215
Titre abrégé: Int J Cancer
Pays: United States
ID NLM: 0042124

Informations de publication

Date de publication:
20 Sep 2024
Historique:
revised: 27 05 2024
received: 18 01 2024
accepted: 25 07 2024
medline: 20 9 2024
pubmed: 20 9 2024
entrez: 20 9 2024
Statut: aheadofprint

Résumé

Salivary carcinomas of minor salivary glands are very infrequent tumors. When located in the tongue, the therapeutic strategy may comprise upfront surgery, which may be debilitating, and/or (chemo-)radiotherapy. The aim of this study was to identify the prognostic factors of salivary carcinomas of the tongue in a population-based cohort. This retrospective multicentric study, based on the "Réseau d'Expertise Français sur les Cancers ORL Rares" (REFCOR), included all the patients with a salivary carcinoma of the tongue, diagnosed between January 2009 and December 2018. Dubious slides were reviewed by REFCOR expert pathologists to ensure diagnostic accuracy. Treatment was performed in accordance with national REFCOR recommendations. From 28 centers, 103 patients were included in this study. Median age at diagnosis was 63 years, and 60.2% were female. Tumors were adenoid cystic carcinomas (41.7%), mucoepidermoid carcinomas (30.1%), and other adenocarcinomas (28.2%). Primary treatment was surgical for 61.2% of them. Five-year overall survival (OS) and event-free survival (EFS) rates were 84.7% and 38.6%, respectively. In multivariable analysis, EFS was significantly worse in case of nonsurgical treatment, alcohol consumption, and glossotonsillar sulcus involvement. N-positive status was the only significant prognostic factor for OS in multivariable analysis. Salivary carcinomas of the tongue represent a heterogeneous group of rare tumors, with a high risk of recurrence. In this national cohort, surgery was associated with better EFS and N-status was the main independent prognostic factor for OS.

Identifiants

DOI: 10.1002/ijc.35167 PMID: 39301840
pubmed: 39301840
doi: 10.1002/ijc.35167
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 UICC.

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Auteurs

Valentine Poissonnet (V)

Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.
ORCID: 0000-0001-6676-0916

Emmanuelle Uro-Coste (E)

Department of Anatomical Pathology, University Cancer Institute Toulouse, Toulouse, France.

Emilien Chabrillac (E)

Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.

Anouchka Modesto (A)

Department of Radiation Therapy, University Cancer Institute Toulouse-Oncopole, Toulouse, France.

Caroline Even (C)

Head and Neck Oncology Department, Gustave-Roussy Institute, Villejuif, France.

Nicolas Fakhry (N)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Marseille, Marseille, France.

Renaud Garrel (R)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Montpellier, Montpellier, France.

Olivier Malard (O)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Nantes, Nantes, France.

Florian Chatelet (F)

Head and Neck Surgery Department, AP-HP, Hôpital Lariboisière, INSERM UMR 1153 ECSTRRA Team, Paris, France.

Charles Dupin (C)

Department of Radiation Therapy, Bordeaux University Hospital-CHU, Bordeaux, France.

Franck Jegoux (F)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Rennes, Rennes, France.

Philippe Schultz (P)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Strasbourg, Strasbourg, France.

Dorian Culié (D)

Otolaryngology, Head and Neck Surgery Department, Head and Neck University Institute, Nice, France.

Robin Baudouin (R)

Otolaryngology, Head and Neck Surgery Department, Foch Hospital, Paris, France.

Diane Evrard (D)

Otolaryngology, Head and Neck Surgery Department, Bichat Hospital, Paris, France.

Pierre Ransy (P)

Head and Neck Surgery Department, CHU Sart Tilman, University Liege, Liege, Belgium.

Sylvain Morinière (S)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Tours, Tours, France.

Haitham Mirghani (H)

Otolaryngology, Head and Neck Surgery Department, George Pompidou European Hospital, Paris, France.

François Mouawad (F)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Lille, Lille, France.

Christian Righini (C)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Grenoble, Grenoble, France.

Suzy Duflo (S)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Point-à-Pitre, Pointe-a-Pitre, France.

Jean-Paul Marie (JP)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Rouen, Rouen, France.

Florence Jourdan-Soulier (F)

Department of Anatomical Pathology, Toulon Hospital, Toulon, France.

Sarah Atallah (S)

Head and Neck Surgery Department, Tenon Hospital, APHP, Sorbonne University, Paris, France.

Esteban Brenet (E)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Reims, Reims, France.

Chloé Bertolus (C)

Department of Oral and Maxillo-Facial Surgery, Pitié-Salpêtrière Hospital, APHP, Sorbonne Université, Paris, France.

Philippe Ceruse (P)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Lyon, Lyon, France.

Lionel Ramin (L)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Limoges, Limoges, France.

Xavier Dufour (X)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Poitiers, Poitiers, France.

Duc Trung Nguyen (DT)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Nancy, Nancy, France.

Vianney Bastit (V)

Otolaryngology, Head and Neck Surgery Department, University Hospital of Caen, Nancy, France.

Bertille Segier (B)

Statistical Department, Institut Claudius Regaud, University Institute of Cancer, Toulouse, France.

Sébastien Vergez (S)

Otolaryngology, Head and Neck Surgery Department, University Cancer Institute Toulouse and Toulouse University Hospital, Larrey Hospital, Toulouse, France.

Classifications MeSH