Is it possible to obtain substitutes for human milk oligosaccharides from bovine milk, goat milk, or other mammal milks?
content and structural diversity
extraction
functional properties
human milk substitute
milk oligosaccharides
Journal
Comprehensive reviews in food science and food safety
ISSN: 1541-4337
Titre abrégé: Compr Rev Food Sci Food Saf
Pays: United States
ID NLM: 101305205
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
revised:
11
08
2024
received:
18
10
2023
accepted:
19
08
2024
medline:
20
9
2024
pubmed:
20
9
2024
entrez:
20
9
2024
Statut:
ppublish
Résumé
Considering the current level of chemical and biological synthesis technology, it was a sensible selection to obtain milk oligosaccharides (MOs) from other mammals as the potential substitute for human MOs (HMOs) that possessed various structural features in the infant formula. Through a comprehensive analysis of the content, structure, and function of MOs in six distinct varieties of mammal milk, it has been shown that goat milk was the most suitable material for the preparation as a human milk substitute. Goat MOs (GMOs) had a relatively high content and diverse structural features compared to those found in other mammalian milks. The concentration of GMOs in colostrum ranged from 60 to 350 mg/L, whereas in mature milk, it ranged from 200 to 24,00 mg/L. The acidic oligosaccharides in goat milk have attracted considerable attention due to their closeness in acidic content and structural diversity with HMOs. Simultaneously, it was discovered that some structures, like N-glycolylneuraminic acid, were found to have a certain content in GMOs and served essential functional properties. Moreover, studies focused on the extraction of MOs from goat milk indicated that the production of GMOs on an industrial scale was viable. Furthermore, it is imperative to do further study on GMOs to enhance the preparation process, discover of new MOs structures and bioactivity evaluation, which will contribute to the development of both the commercial production of MOs and the goat milk industry.
Identifiants
pubmed: 39302160
doi: 10.1111/1541-4337.70018
doi:
Substances chimiques
Oligosaccharides
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
e70018Subventions
Organisme : Central Guiding Fund for Local Science and Technology Development
ID : 2021Szvup118
Organisme : National Natural Science Foundation of China
ID : 32001652
Organisme : Keypoint Research and Invention Program of Shaanxi Province
ID : 2021ZDLNY05-06
Informations de copyright
© 2024 Institute of Food Technologists®.
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