PRDM16 determines specification of ventricular cardiomyocytes by suppressing alternative cell fates.

Myocytes, Cardiac / metabolism Animals Mice Transcription Factors / metabolism Heart Ventricles / metabolism DNA-Binding Proteins / metabolism Cell Differentiation / genetics Cell Lineage / genetics Gene Expression Regulation, Developmental / genetics Mice, Knockout Single-Cell Analysis

Journal

Life science alliance
ISSN: 2575-1077
Titre abrégé: Life Sci Alliance
Pays: United States
ID NLM: 101728869

Informations de publication

Date de publication:
Dec 2024
Historique:
received: 14 03 2024
revised: 06 09 2024
accepted: 09 09 2024
medline: 21 9 2024
pubmed: 21 9 2024
entrez: 20 9 2024
Statut: epublish

Résumé

PRDM16 is a transcription factor with histone methyltransferase activity expressed at the earliest stages of cardiac development. Pathogenic mutations in humans lead to cardiomyopathy, conduction abnormalities, and heart failure. PRDM16 is specifically expressed in ventricular but not atrial cardiomyocytes, and its expression declines postnatally. Because in other tissues PRDM16 is best known for its role in binary cell fate decisions, we hypothesized a similar decision-making function in cardiomyocytes. Here, we demonstrated that cardiomyocyte-specific deletion of

Identifiants

DOI: 10.26508/lsa.202402719 PMID: 39304345
pubmed: 39304345
pii: 7/12/e202402719
doi: 10.26508/lsa.202402719
pii:
doi:

Substances chimiques

Prdm16 protein, mouse 0
Transcription Factors 0
DNA-Binding Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024 Van Wauwe et al.

Auteurs

Jore Van Wauwe (J)

https://ror.org/05f950310 Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0003-2969-1805

Alexia Mahy (A)

https://ror.org/05f950310 Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0009-0005-3880-3946

Sander Craps (S)

https://ror.org/05f950310 Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-8574-7044

Samaneh Ekhteraei-Tousi (S)

https://ror.org/05f950310 Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-8123-8058

Pieter Vrancaert (P)

https://ror.org/05f950310 Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.

Hannelore Kemps (H)

https://ror.org/05f950310 Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0001-9248-1697

Wouter Dheedene (W)

https://ror.org/05f950310 Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0001-8798-0395

Rosa Doñate Puertas (R)

https://ror.org/05f950310 Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-9230-6765

Sander Trenson (S)

https://ror.org/05f950310 Cardiology Lab, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0002-3902-0047

H Llewelyn Roderick (HL)

https://ror.org/05f950310 Laboratory of Experimental Cardiology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium.
ORCID: 0000-0001-7065-3523

Manu Beerens (M)

Institute for Clinical Chemistry and Laboratory Medicine, Medizinische Klinik und Poliklinik Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
German Centre of Cardiovascular Research (DZHK), Partner Site Hamburg, Luebeck, Kiel, Hamburg, Germany.
ORCID: 0000-0002-7398-7761

Aernout Luttun (A)

https://ror.org/05f950310 Center for Molecular and Vascular Biology, Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium aernout.luttun@kuleuven.be.
ORCID: 0000-0001-7902-9524

Articles similaires

Evaluating the efficacy of telesurgery with dual console SSI Mantra Surgical Robotic System: experiment on animal model and clinical trials.

Sudhir Prem Srivastava, Vishwajyoti Pascual Srivastava, Avinesh Singh et al.
1.00
Robotic Surgical Procedures Animals Humans Telemedicine Models, Animal

Odour generalisation and detection dog training.

Lyn Caldicott, Thomas W Pike, Helen E Zulch et al.
1.00
Animals Odorants Dogs Generalization, Psychological Smell

FBXO22 inhibits colitis and colorectal carcinogenesis by regulating the degradation of the S2448-phosphorylated form of mTOR.

Minle Li, Xuan Chen, Pengfei Qu et al.
1.00
Animals TOR Serine-Threonine Kinases Colorectal Neoplasms Colitis Mice

Use of organic material provided by an automatic enrichment device by weaner pigs and its influence on tail lesions.

Philipp Heseker, Jeanette Probst, Stefanie Ammer et al.
1.00
Animals Tail Swine Behavior, Animal Animal Husbandry

Classifications MeSH

questionsmedicales.fr › Cellules › Cellules musculaires › Myocytes cardiaques › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Eucaryotes › Animaux › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Système cardiovasculaire › Coeur › Ventricules cardiaques › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de liaison à l'ADN › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Développement embryonnaire et foetal › Développement embryonnaire › Lignage cellulaire › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › PRDM16 determines specification of ventricular...
questionsmedicales.fr › Techniques d'investigation › Techniques cytologiques › Analyse sur cellule unique › PRDM16 determines specification of ventricular...