Design, synthesis, in-vitro, in-silico, DFT and POM studies of a novel family of sulfonamides as potent anti-triple-negative breast cancer agents.

ADMET Anti-breast cancer agents Breast cancer Ethacrynic acid Indazole-sulfonamides Molecular docking POM

Journal

Computational biology and chemistry
ISSN: 1476-928X
Titre abrégé: Comput Biol Chem
Pays: England
ID NLM: 101157394

Informations de publication

Date de publication:
19 Sep 2024
Historique:
received: 01 07 2024
revised: 04 09 2024
accepted: 12 09 2024
medline: 22 9 2024
pubmed: 22 9 2024
entrez: 21 9 2024
Statut: aheadofprint

Résumé

In this study, a new family of ethacrynic acid-sulfonamides and indazole-sulfonamides was synthesized and tested in vitro against MDA-MB-468 triple-negative breast cancer cells and PBMCs human peripheral blood mononuclear cells, using the MTT (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide) assay. The aim of this research is to discover novel compounds with potential therapeutic effects on breast cancer. The antiproliferative activity of these compounds showed a significant dose-dependent activity, with IC

Identifiants

DOI: 10.1016/j.compbiolchem.2024.108214 PMID: 39305691
pubmed: 39305691
pii: S1476-9271(24)00202-0
doi: 10.1016/j.compbiolchem.2024.108214
pii:
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

108214

Informations de copyright

Copyright © 2024 Elsevier Ltd. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests:EL KAZZOULI Said reports was provided by Euro-Mediterranean University of Fes Euromed Research Center. EL KAZZOULI Said reports a relationship with Euro-Mediterranean University of Fes Euromed Research Center that includes: employment. If there are other authors, they declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Nassima Saghdani (N)

Euromed University of Fes, UEMF, Morocco.

Abdelmoula El Abbouchi (A)

Euromed University of Fes, UEMF, Morocco.

Nabil El Brahmi (N)

Euromed University of Fes, UEMF, Morocco.

Abderrazak Idir (A)

Agro-Industrial and Medical Biotechnology Laboratory, Team of Experimental Oncology and Natural Substances, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni-Mellal, Morocco; Science and Technology Team, Higher School of Education and Training, Chouaîb Doukkali University, El Jadida, Morocco.

Khadija Otmane Rachedi (KO)

Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Faculty of Sciences, Department of Chemistry, Badji-Mokhtar - Annaba University, Box 12, Annaba 23000, Algeria.

Malika Berredjem (M)

Laboratory of Applied Organic Chemistry, Synthesis of Biomolecules and Molecular Modelling Group, Faculty of Sciences, Department of Chemistry, Badji-Mokhtar - Annaba University, Box 12, Annaba 23000, Algeria.

Rachid Haloui (R)

Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, BP Box 72, Fez, Morocco.

Souad Elkhattabi (S)

Laboratory of Engineering, Systems and Applications, National School of Applied Sciences, Sidi Mohamed Ben Abdellah-Fez University, BP Box 72, Fez, Morocco.

Hassan Ait Mouse (HA)

Agro-Industrial and Medical Biotechnology Laboratory, Team of Experimental Oncology and Natural Substances, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni-Mellal, Morocco.

Taibi Ben Hadda (T)

Euromed University of Fes, UEMF, Morocco.

Mostapha Bousmina (M)

Euromed University of Fes, UEMF, Morocco.

Abdelmajid Zyad (A)

Agro-Industrial and Medical Biotechnology Laboratory, Team of Experimental Oncology and Natural Substances, Faculty of Sciences and Technology, Sultan Moulay Slimane University, Beni-Mellal, Morocco.

Saïd El Kazzouli (S)

Euromed University of Fes, UEMF, Morocco. Electronic address: s.elkazzouli@ueuromed.org.

Classifications MeSH