Immune response and safety of co-administered peste des petits ruminants, contagious caprine pleuropneumonia, sheep and goat pox, and Pasteurellosis vaccines in goats.
Animals
Goats
Goat Diseases
/ prevention & control
Peste-des-Petits-Ruminants
/ prevention & control
Pleuropneumonia, Contagious
/ prevention & control
Viral Vaccines
/ immunology
Bacterial Vaccines
/ administration & dosage
Peste-des-petits-ruminants virus
/ immunology
Poxviridae Infections
/ veterinary
Sheep
Sheep Diseases
/ prevention & control
Ethiopia
Capripoxvirus
/ immunology
Female
Male
Ethiopia
Goats
Immunogenicity
Multiple vaccines
Safety
Journal
Open veterinary journal
ISSN: 2218-6050
Titre abrégé: Open Vet J
Pays: Libya
ID NLM: 101653182
Informations de publication
Date de publication:
Aug 2024
Aug 2024
Historique:
received:
19
05
2024
accepted:
11
07
2024
medline:
23
9
2024
pubmed:
23
9
2024
entrez:
23
9
2024
Statut:
ppublish
Résumé
Infectious diseases such as peste des petits ruminants (PPRs), contagious caprine pleuropneumonia (CCPP), sheep and goat pox (SGPX), and pasteurellosis have considerable impacts on the optimal utilization of sheep and goat resources in Ethiopia. Immunization using multiple vaccines administered simultaneously has been suggested as a cost-effective and safe approach to controlling and preventing these diseases. The aim of this study was to assess the immunogenicity and safety of multiple vaccines administered simultaneously in goats. Sero-negative PPR, CCPP, SGPX, and Pasteurellosis goats were immunized with multiple vaccines. Goats vaccinated with a single vaccine against each disease served as a positive control. The immune response of the goats was assessed using serological tests, and any adverse effects were monitored. The results of the present study showed that goats vaccinated with multiple vaccines exhibited a remarkable immune response against PPR, CCPP, and pasteurellosis. In contrast, they did not produce a protective immune response against sheep or goat pox. No adverse effects were observed with any of the vaccines. This study suggested that combined vaccines can be effective at inducing a protective immune response in goats. However, further research is needed to fully understand the immune response to combined vaccines.
Sections du résumé
Background
UNASSIGNED
Infectious diseases such as peste des petits ruminants (PPRs), contagious caprine pleuropneumonia (CCPP), sheep and goat pox (SGPX), and pasteurellosis have considerable impacts on the optimal utilization of sheep and goat resources in Ethiopia. Immunization using multiple vaccines administered simultaneously has been suggested as a cost-effective and safe approach to controlling and preventing these diseases.
Aim
UNASSIGNED
The aim of this study was to assess the immunogenicity and safety of multiple vaccines administered simultaneously in goats.
Methods
UNASSIGNED
Sero-negative PPR, CCPP, SGPX, and Pasteurellosis goats were immunized with multiple vaccines. Goats vaccinated with a single vaccine against each disease served as a positive control. The immune response of the goats was assessed using serological tests, and any adverse effects were monitored.
Results
UNASSIGNED
The results of the present study showed that goats vaccinated with multiple vaccines exhibited a remarkable immune response against PPR, CCPP, and pasteurellosis. In contrast, they did not produce a protective immune response against sheep or goat pox. No adverse effects were observed with any of the vaccines.
Conclusion
UNASSIGNED
This study suggested that combined vaccines can be effective at inducing a protective immune response in goats. However, further research is needed to fully understand the immune response to combined vaccines.
Identifiants
pubmed: 39308707
doi: 10.5455/OVJ.2024.v14.i8.25
pii: OVJ-14-1960
pmc: PMC11415898
doi:
Substances chimiques
Viral Vaccines
0
Bacterial Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1960-1967Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest.