Chronic thromboembolic pulmonary hypertension: the diagnostic assessment.

chronic thromboembolic pulmonary hypertension (CTEPH) diagnosis narrative review pulmonary hypertension rare disease

Journal

Frontiers in cardiovascular medicine
ISSN: 2297-055X
Titre abrégé: Front Cardiovasc Med
Pays: Switzerland
ID NLM: 101653388

Informations de publication

Date de publication:
2024
Historique:
received: 27 05 2024
accepted: 28 08 2024
medline: 23 9 2024
pubmed: 23 9 2024
entrez: 23 9 2024
Statut: epublish

Résumé

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) presents a significant diagnostic challenge due to its complex and often nonspecific clinical manifestations. This review outlines a comprehensive approach to the diagnostic assessment of CTEPH, emphasizing the importance of a high index of suspicion in patients with unexplained dyspnea or persistent symptoms post-acute pulmonary embolism. We discuss the pivotal role of multimodal imaging, including echocardiography, ventilation/perfusion scans, CT pulmonary angiography, and magnetic resonance imaging, in the identification and confirmation of CTEPH. Furthermore, the review highlights the essential function of right heart catheterization in validating the hemodynamic parameters indicative of CTEPH, establishing its definitive diagnosis. Advances in diagnostic technologies and the integration of a multidisciplinary approach are critical for the timely and accurate diagnosis of CTEPH, facilitating early therapeutic intervention and improving patient outcomes. This manuscript aims to equip clinicians with the knowledge and tools necessary for the efficient diagnostic workflow of CTEPH, promoting awareness and understanding of this potentially treatable cause of pulmonary hypertension.

Identifiants

pubmed: 39309600
doi: 10.3389/fcvm.2024.1439402
pmc: PMC11412851
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

1439402

Informations de copyright

© 2024 Simeone, Maggio, Schirone, Rocco, Sarto, Spadafora, Bernardi, Ambrosio, Forte, Vecchio, Valenti, Sciarretta and Vizza.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Beatrice Simeone (B)

Department of Cardiology, ICOT Istituto Marco Pasquali, Latina, Italy.

Enrico Maggio (E)

Department of Clinical Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Rome, Italy.

Leonardo Schirone (L)

Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Italy.

Erica Rocco (E)

Department of Cardiology, ICOT Istituto Marco Pasquali, Latina, Italy.

Gianmarco Sarto (G)

Department of Cardiology, ICOT Istituto Marco Pasquali, Latina, Italy.

Luigi Spadafora (L)

Department of Cardiology, ICOT Istituto Marco Pasquali, Latina, Italy.

Marco Bernardi (M)

Department of Cardiology, ICOT Istituto Marco Pasquali, Latina, Italy.

Luca D' Ambrosio (L)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Maurizio Forte (M)

Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Italy.

Daniele Vecchio (D)

Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Valentina Valenti (V)

Department of Cardiology, Santa Maria Goretti Hospital, Latina, Italy.
Department of Cardiology, Maria Cecilia Hospital, GVM Care & Research, Cotignola, Italy.

Sebastiano Sciarretta (S)

Department of Angiocardioneurology, IRCCS Neuromed, Pozzilli, Italy.
Department of Medical-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina, Italy.

Carmine Dario Vizza (CD)

Department of Cardiovascular and Respiratory Sciences, Sapienza University of Rome, Rome, Italy.

Classifications MeSH