Impact of putatively beneficial genomic loci on gene expression in little brown bats (
Myotis lucifugus
White‐nose syndrome
disease
eQTL
evolution
expression
Journal
Evolutionary applications
ISSN: 1752-4571
Titre abrégé: Evol Appl
Pays: England
ID NLM: 101461828
Informations de publication
Date de publication:
Sep 2024
Sep 2024
Historique:
received:
06
08
2023
revised:
06
06
2024
accepted:
19
06
2024
medline:
23
9
2024
pubmed:
23
9
2024
entrez:
23
9
2024
Statut:
epublish
Résumé
Genome-wide scans for selection have become a popular tool for investigating evolutionary responses in wildlife to emerging diseases. However, genome scans are susceptible to false positives and do little to demonstrate specific mechanisms by which loci impact survival. Linking putatively resistant genotypes to observable phenotypes increases confidence in genome scan results and provides evidence of survival mechanisms that can guide conservation and management efforts. Here we used an expression quantitative trait loci (eQTL) analysis to uncover relationships between gene expression and alleles associated with the survival of little brown bats (
Identifiants
pubmed: 39310794
doi: 10.1111/eva.13748
pii: EVA13748
pmc: PMC11413065
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e13748Informations de copyright
© 2024 The Author(s). Evolutionary Applications published by John Wiley & Sons Ltd.
Déclaration de conflit d'intérêts
The authors of this manuscript have no conflicts of interest to report.