[Life style drug laughing gas (nitrous oxide, N
Trenddroge Lachgas (Distickstoffmonoxid, N
Adolescent behavior, drug effects
Neurological manifestations, drug effects
Nitrous oxide, adverse effects
Substance abuse, psychology
Substance-related disorders, psychology
Journal
Der Nervenarzt
ISSN: 1433-0407
Titre abrégé: Nervenarzt
Pays: Germany
ID NLM: 0400773
Informations de publication
Date de publication:
23 Sep 2024
23 Sep 2024
Historique:
accepted:
02
08
2024
medline:
23
9
2024
pubmed:
23
9
2024
entrez:
23
9
2024
Statut:
aheadofprint
Résumé
The increasing popularity of nitrous oxide (N A comprehensive literature search until April 2024 was conducted to identify publications addressing N Studies showed mixed results regarding craving and loss of control among N The data on the dependency potential of N Nitrous oxide is currently primarily regarded as a substance of abuse with the potential to foster psychological dependence, manifesting particularly through loss of control and neglect; however, the criteria for physical dependence, such as the occurrence of withdrawal syndromes and the development of tolerance, have not yet been convincingly documented. Further research is needed to better understand the dependency potential of N FRAGESTELLUNG: Die steigende Beliebtheit von Lachgas (Distickstoffmonoxid, N Eine umfassende Literatursuche bis April 2024 wurde durchgeführt, um Publikationen zu identifizieren, die den Konsum von N Studien zeigen gemischte Ergebnisse hinsichtlich des Cravings und Kontrollverlusts bei N Die Datenlage zum Abhängigkeitspotenzial von N Lachgas wird gegenwärtig vor allem als Missbrauchssubstanz betrachtet und hat das Potenzial, bei exzessivem Konsum eine psychische Abhängigkeit zu fördern, die sich insbesondere durch Kontrollverlust und Vernachlässigung äußert. Die Kriterien für eine körperliche Abhängigkeit, wie das Auftreten eines Entzugssyndroms und die Entwicklung von Toleranz, sind bisher jedoch noch nicht ausreichend überzeugend dokumentiert worden. Weitere Forschung ist erforderlich, um das Abhängigkeitspotenzial von N
Autres résumés
Type: Publisher
(ger)
FRAGESTELLUNG: Die steigende Beliebtheit von Lachgas (Distickstoffmonoxid, N
Identifiants
pubmed: 39311917
doi: 10.1007/s00115-024-01736-z
pii: 10.1007/s00115-024-01736-z
doi:
Types de publication
English Abstract
Journal Article
Review
Langues
ger
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Back S, Kroon E, Colyer-Patel K, Cousijn J (2024) Does nitrous oxide addiction exist? An evaluation of the evidence for the presence and prevalence of substance use disorder symptoms in recreational nitrous oxide users. Addiction 119:609–618
doi: 10.1111/add.16380
pubmed: 37904333
Back S, Kroon E, Colyer-Patel K, Cousijn J (2024) Nitrous oxide addiction or not, action is needed. A response to commentaries. Addiction 119:627–628
doi: 10.1111/add.16457
pubmed: 38404020
Benturquia N, Le Marec T, Scherrmann JM, Noble F (2008) Effects of nitrous oxide on dopamine release in the rat nucleus accumbens and expectation of reward. Neuroscience 155:341–344
doi: 10.1016/j.neuroscience.2008.05.015
pubmed: 18571333
Brunt TM (2024) Nitrous oxide: a difficult case for classification as an addictive substance. Addiction 119:621–622
doi: 10.1111/add.16419
pubmed: 38123187
Dawudi Y, Azoyan L, Broucker TDE et al (2024) Marked increase in severe neurological disorders after nitrous oxide abuse: a retrospective study in the Greater Paris area. J Neurol. https://doi.org/10.1007/s00415-024-12264-w
doi: 10.1007/s00415-024-12264-w
pubmed: 38478030
pmcid: 11136741
Fidalgo M, Prud’homme T, Allio A et al (2019) Nitrous oxide: what do we know about its use disorder potential? Results of the French monitoring centre for addiction network survey and literature review. Subst Abus 40:33–42
doi: 10.1080/08897077.2019.1573210
pubmed: 30913001
Garakani A, Jaffe RJ, Savla D et al (2016) Neurologic, psychiatric, and other medical manifestations of nitrous oxide abuse: a systematic review of the case literature. Am J Addict 25:358–369
doi: 10.1111/ajad.12372
pubmed: 27037733
Gernez E, Lee GR, Niguet JP et al (2023) Nitrous oxide abuse: clinical outcomes, pharmacology, pharmacokinetics, toxicity and impact on metabolism. Toxics. https://doi.org/10.3390/toxics11120962
doi: 10.3390/toxics11120962
pubmed: 38133363
pmcid: 10747624
Gillman MA (1986) Nitrous oxide, an opioid addictive agent: review of the evidence. Am J Med 81:97–102
doi: 10.1016/0002-9343(86)90189-0
pubmed: 3014879
Kaar SJ, Ferris J, Waldron J et al (2016) Up: the rise of nitrous oxide abuse. An international survey of contemporary nitrous oxide use. J Psychopharmacol 30:395–401
doi: 10.1177/0269881116632375
pubmed: 26912510
Kalmoe MC, Janski AM, Zorumski CF et al (2020) Ketamine and nitrous oxide: the evolution of NMDA receptor antagonists as antidepressant agents. J Neurol Sci 412:116778
doi: 10.1016/j.jns.2020.116778
pubmed: 32240970
Kingwell E, Marriott JJ, Jetté N et al (2013) Incidence and prevalence of multiple sclerosis in Europe: a systematic review. BMC Neurol 13:128
doi: 10.1186/1471-2377-13-128
pubmed: 24070256
pmcid: 3856596
Lucas A, Noyce AJ, Gernez E et al (2024) Nitrous oxide abuse direct measurement for diagnosis and follow-up: update on kinetics and impact on metabolic pathways. Clin Chem Lab Med. https://doi.org/10.1515/cclm-2023-1252
doi: 10.1515/cclm-2023-1252
pubmed: 38377044
Nabben T, Weijs J, van Amsterdam J (2021) Problematic use of nitrous oxide by young Moroccan-Dutch adults. Int J Environ Res Public Health. https://doi.org/10.3390/ijerph18115574
doi: 10.3390/ijerph18115574
pubmed: 34071087
pmcid: 8197142
Nugteren-Van Lonkhuyzen JJ, van der Ben L, van den Hengel-Koot IS et al (2023) High incidence of signs of neuropathy and self-reported substance use disorder for nitrous oxide in patients intoxicated with nitrous oxide. Eur Addict Res 29:202–212
doi: 10.1159/000530123
pubmed: 37100039
WHO (2024) WHOExpert committee on drug dependence: forty-sixth report
Falkai P (2013) Diagnostic and statistical manual of mental disorders: DSM‑5. American Psychiatric Publ, Washington, DC
Ramsay DS, Watson CH, Leroux BG et al (2003) Conditioned place aversion and self-administration of nitrous oxide in rats. Pharmacol Biochem Behav 74:623–633
doi: 10.1016/S0091-3057(02)01048-1
pubmed: 12543228
https://www.emcdda.europa.eu/publications/european-drug-report/2023_en . Zugegriffen: 5. Mai 2024
https://www.gov.uk/government/news/nitrous-oxide-to-be-illegal-from-november . Zugegriffen: 24. Apr. 2024
https://www.spiegel.de/wissenschaft/drogen-mediziner-warnen-vor-aktuellen-trenddrogen-lachgas-und-benzodiazepinen-a-975b5178-8cdc-4362-9495-61c76e48a42e . Zugegriffen: 24. Apr. 2024
https://www.t-online.de/region/berlin/id_100376890/berlin-das-sind-die-neuen-trenddrogen-bei-jugendlichen.html . Zugegriffen: 24. Apr. 2024
van Amsterdam J, Nabben T, van den Brink W (2015) Recreational nitrous oxide use: prevalence and risks. Regul Toxicol Pharmacol 73:790–796
doi: 10.1016/j.yrtph.2015.10.017
pubmed: 26496821
van den Toren SJ, van Grieken A, Raat H (2021) Associations of socio-demographic characteristics, well-being, school absenteeism, and substance use with recreational nitrous oxide use among adolescents: a cross-sectional study. PLoS ONE 16:e247230
doi: 10.1371/journal.pone.0247230
pubmed: 33600449
pmcid: 7891713
Victorri-Vigneau C, Grall Bronnec M (2024) Yes, nitrous oxide addiction undeniably exists! Addiction 119:625–626
doi: 10.1111/add.16430
pubmed: 38196069
Whitwam JG, Morgan M, Hall GM, Petrie A (1977) PAIN DURING CONTINUOUS NITROUS OXIDE ADMINISTRATION. Surv Anesthesiol. https://doi.org/10.1097/00132586-197712000-00037
doi: 10.1097/00132586-197712000-00037
Winstock AR, Ferris JA (2020) Nitrous oxide causes peripheral neuropathy in a dose dependent manner among recreational users. J Psychopharmacol 34:229–236
doi: 10.1177/0269881119882532
pubmed: 31679459
Yajnik S, Zacny JP, Young CJ et al (1996) Lack of acute tolerance development to the subjective, cognitive, and psychomotor effects of nitrous oxide in healthy volunteers. Pharmacol Biochem Behav 54:501–508
doi: 10.1016/0091-3057(95)02278-3
pubmed: 8743615
Zheng D, Ba F, Bi G et al (2020) The sharp rise of neurological disorders associated with recreational nitrous oxide use in China: a single-center experience and a brief review of Chinese literature. J Neurol 267:422–429
doi: 10.1007/s00415-019-09600-w
pubmed: 31655888
Busardò FP, Jones AW (2015) GHB pharmacology and toxicology: acute intoxication, concentrations in blood and urine in forensic cases and treatment of the withdrawal syndrome. Curr Neuropharmacol 13(1):47–70
doi: 10.2174/1570159X13666141210215423
pubmed: 26074743
pmcid: 4462042