Post-hospitalisation COVID-19 cognitive deficits at one year are global and associated with elevated brain injury markers and grey matter volume reduction.

Journal

Nature medicine
ISSN: 1546-170X
Titre abrégé: Nat Med
Pays: United States
ID NLM: 9502015

Informations de publication

Date de publication:
23 Sep 2024
Historique:
received: 28 12 2023
accepted: 18 09 2024
medline: 24 9 2024
pubmed: 24 9 2024
entrez: 23 9 2024
Statut: aheadofprint

Résumé

The spectrum, pathophysiology, and recovery trajectory of persistent post-COVID-19 cognitive deficits are unknown, limiting our ability to develop prevention and treatment strategies. We report the one-year cognitive, serum biomarker, and neuroimaging findings from a prospective, national study of cognition in 351 COVID-19 patients who had required hospitalisation, compared to 2,927 normative matched controls. Cognitive deficits were global and associated with elevated brain injury markers, and reduced anterior cingulate cortex volume one year after COVID-19. The severity of the initial infective insult, post-acute psychiatric symptoms, and a history of encephalopathy were associated with greatest deficits. There was strong concordance between subjective and objective cognitive deficits. Longitudinal follow-up in 106 patients demonstrated a trend toward recovery. Together, these findings support the hypothesis that brain injury in moderate to severe COVID-19 may be immune-mediated, and should guide the development of therapeutic strategies.

Identifiants

DOI: 10.1038/s41591-024-03309-8 PMID: 39312956
pubmed: 39312956
doi: 10.1038/s41591-024-03309-8
pii: 10.1038/s41591-024-03309-8
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : RCUK | Medical Research Council (MRC)
ID : MR/V03605X/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MC_PC_19059
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/V007181/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/T028750/1
Organisme : RCUK | Medical Research Council (MRC)
ID : MR/V03605X/1
Organisme : DH | National Institute for Health Research (NIHR)
ID : CO-CIN-01
Organisme : DH | National Institute for Health Research (NIHR)
ID : ACF-2022-07-007
Organisme : Wellcome Trust (Wellcome)
ID : ISSF201902/3

Investigateurs

Ali M Alam (AM)
Ammar Al-Chalabi (A)
Christopher M Allen (CM)
Jay Amin (J)
Cherie Armour (C)
Mark R Baker (MR)
Suzanne Barrett (S)
Neil Basu (N)
Rahul Batra (R)
Laura Benjamin (L)
Alex Berry (A)
Richard Bethlehem (R)
Bethan Blackledge (B)
Sarah A Boardman (SA)
John R Bradley (JR)
David P Breen (DP)
Judith Breuer (J)
Matthew R Broome (MR)
Edward Bullmore (E)
Matthew Butler (M)
Hannah Castell (H)
Jonathan Cavanagh (J)
David Christmas (D)
David M Christmas (DM)
Jonathan R I Coleman (JRI)
Alaistair Coles (A)
Ceryce Collie (C)
Nadine Cossette (N)
David Cousins (D)
Alastair Darby (A)
Nicholas Davies (N)
Sylviane Defres (S)
Katherine C Dodd (KC)
Alex Dregan (A)
Eugene Duff (E)
Mark A Ellul (MA)
Nikos Evangelou (N)
Peter M Fernandes (PM)
Richard Francis (R)
Ian Galea (I)
Afagh Garjani (A)
Lily George (L)
Valentina Giunchiglia (V)
Kiran Glen (K)
Rebecca Gregory (R)
Michael Griffiths (M)
Victoria Grimbly (V)
Alexander Grundmann (A)
Savini Gunatilake (S)
Shahd H M Hamid (SHM)
Marc Hardwick (M)
Jade D Harris (JD)
Ewan Harrison (E)
Paul J Harrison (PJ)
Monika Hartmann (M)
Claire Hetherington (C)
Orla Hilton (O)
Julian Hiscox (J)
Eva Maria Hodel (EM)
Angela E Holland (AE)
Yun Huang (Y)
Stella Hughes (S)
Sarosh Irani (S)
Thomas M Jenkins (TM)
Johan Kallberg Zvrskovec (JK)
Sandar Kyaw (S)
Gabriella Lewis (G)
James B Lilleker (JB)
Michael P Lunn (MP)
Claire L MacIver (CL)
Daniel Madarshahian (D)
Parisa Mansoori (P)
Naomi Martin (N)
Gavin McDonnell (G)
Emily McGlinchey (E)
Stephen McKeever (S)
Ryan McIlwaine (R)
Andrew M McIntosh (AM)
Karla Miller (K)
Dina Monssen (D)
Christopher M Morris (CM)
Ciaran Mulholland (C)
Akshay Nair (A)
Virginia Newcombe (V)
Nathalie Nicholas (N)
Timothy Nicholson (T)
Ronan O'Malley (R)
Obioma Orazulume (O)
Marlies Ostermann (M)
Alish Palmos (A)
Arvind Patel (A)
Sharon Peacock (S)
Sophie Pendered (S)
Thomas Pollak (T)
Angela Roberts (A)
Silvia Rota (S)
Rustam Al-Shahi Salman (RA)
Merna Samuel (M)
Brendan Sargent (B)
Stephen J Sawcer (SJ)
Adam W Seed (AW)
Scott Semple (S)
Rajish S K Shil (RSK)
Adam Sieradzki (A)
Bhagteshwar Singh (B)
Craig J Smith (CJ)
Jacqueline Smith (J)
Stephen Smith (S)
Leonie Taams (L)
Arina Tamborska (A)
Rhys H Thomas (RH)
Emma Thomson (E)
William Trender (W)
Zain Ul-Abideen Ahmad (ZU)
Jonathan Underwood (J)
Tonny Veenith (T)
Annalena Venneri (A)
Daniel J van Wamelen (DJ)
Guy B Williams (GB)
Sui Hsien Wong (SH)
Michael S Zandi (MS)

Informations de copyright

© 2024. The Author(s), under exclusive licence to Springer Nature America, Inc.

Auteurs

Greta K Wood (GK)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Liverpool University Hospitals NHS Foundation Trust, Liverpool, UK.
ORCID: 0000-0001-6098-2331

Brendan F Sargent (BF)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Department of Psychiatry, Warneford Hospital, University of Oxford, Oxford, UK.
Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

Zain-Ul-Abideen Ahmad (ZU)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
ORCID: 0000-0002-6940-8851

Kukatharmini Tharmaratnam (K)

Department of Health Data Science, Institute of Population Health, University of Liverpool, Liverpool, UK.
ORCID: 0000-0002-8255-9822

Cordelia Dunai (C)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Franklyn N Egbe (FN)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
ORCID: 0000-0002-9547-4609

Naomi H Martin (NH)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Bethany Facer (B)

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Sophie L Pendered (SL)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.

Henry C Rogers (HC)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Christopher Hübel (C)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
National Centre for Register-based Research, Aarhus Business and Social Sciences, Aarhus University, Aarhus, Denmark.
Department of Pediatric Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.

Daniel J van Wamelen (DJ)

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Parkinson's Foundation Center of Excellence, King's College Hospital, London, UK.
Department of Neurology; Centre of Expertise for Parkinson & Movement Disorders, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, the Netherlands.
ORCID: 0000-0003-0921-5158

Richard A I Bethlehem (RAI)

Department of Psychology, University of Cambridge, Cambridge, UK.

Valentina Giunchiglia (V)

Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

Peter J Hellyer (PJ)

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

William Trender (W)

Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.
ORCID: 0000-0003-3947-5532

Gursharan Kalsi (G)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Edward Needham (E)

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-7042-7462

Ava Easton (A)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
Encephalitis International, Malton, UK.
ORCID: 0000-0002-1739-2915

Thomas A Jackson (TA)

Institute of Inflammation and Ageing, University of Birmingham, Birmingham, UK.

Colm Cunningham (C)

School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Dublin, Ireland.
ORCID: 0000-0003-1423-5209

Rachel Upthegrove (R)

Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
ORCID: 0000-0001-8204-5103

Thomas A Pollak (TA)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
South London and Maudsley NHS Foundation Trust, London, UK.
ORCID: 0000-0002-6171-0810

Matthew Hotopf (M)

Department of Psychological Medicine, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

Tom Solomon (T)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK.
The Pandemic Institute, University of Liverpool, Liverpool, UK.
Department of Neurology, Walton Centre Foundation Trust, Liverpool, UK.
ORCID: 0000-0001-7266-6547

Sarah L Pett (SL)

MRC Clinical Trials Unit, UCL, London, UK.
Institute of Clinical Trials and Methodology, UCL, London, UK.
Institute for Global Health, UCL, London, UK.

Pamela J Shaw (PJ)

Division of Neuroscience, School of Medicine and Population Health, University of Sheffield, Sheffield, UK.
Sheffield Institute for Translational Neuroscience, NIHR Biomedical Research Centre, University of Sheffield, Sheffield, UK.
ORCID: 0000-0002-8925-2567

Nicholas Wood (N)

Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, UCL, London, UK.
UCL Genetics Institute, Division of Biosciences, UCL, London, UK.
ORCID: 0000-0002-9500-3348

Neil A Harrison (NA)

Cardiff University Brain Research Imaging Centre, School of Medicine, Cardiff University, Cardiff, UK.
ORCID: 0000-0002-9584-3769

Karla L Miller (KL)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.

Peter Jezzard (P)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.
ORCID: 0000-0001-7912-2251

Guy Williams (G)

Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
ORCID: 0000-0001-5223-6654

Eugene P Duff (EP)

UK Dementia Research Institute, Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

Steven Williams (S)

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
ORCID: 0000-0003-4299-1941

Fernando Zelaya (F)

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
NIHR Maudsley Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK.
ORCID: 0000-0002-9525-1560

Stephen M Smith (SM)

Wellcome Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences, Oxford University, Oxford, UK.
ORCID: 0000-0001-8166-069X

Simon Keller (S)

Department of Pharmacology and Therapeutics, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, UK.

Matthew Broome (M)

Institute for Mental Health, School of Psychology, University of Birmingham, Birmingham, UK.
Birmingham Women's and Children's NHS Foundation Trust, Birmingham, UK.
ORCID: 0000-0002-6963-8884

Nathalie Kingston (N)

NIHR Bioresource, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
Department of Haematology, School of Clinical Medicine, University of Cambridge, Cambridge Biomedical Campus, Cambridge, UK.
ORCID: 0000-0002-9190-2231

Masud Husain (M)

Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford, UK.
Department of Experimental Psychology, University of Oxford, Oxford, UK.
ORCID: 0000-0002-6850-9255

Angela Vincent (A)

Nuffield Department of Clinical Neuroscience, John Radcliffe Hospital, University of Oxford, Oxford, UK.
ORCID: 0000-0003-2395-8695

John Bradley (J)

NIHR Bioresource, Cambridge University Hospitals NHS Foundation Trust, Cambridge Biomedical Campus, Cambridge, UK.
ORCID: 0000-0002-7774-8805

Patrick Chinnery (P)

Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, UK.

David K Menon (DK)

Section of Perioperative, Acute, Critical Care and Emergency Medicine, Department of Medicine, University of Cambridge, Cambridge, UK.
ORCID: 0000-0002-3228-9692

John P Aggleton (JP)

School of Psychology, Cardiff University, Cardiff, UK.

Timothy R Nicholson (TR)

Department of Psychosis Studies, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
South London and Maudsley NHS Foundation Trust, London, UK.
Neuropsychiatry Research and Education Group, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.

John-Paul Taylor (JP)

Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
Old Age Psychiatry, Tyne and Wear NHS Trust, Northumberland, UK.

Anthony S David (AS)

Department of Psychiatry, Institute of Mental Health, UCL, London, UK.
ORCID: 0000-0003-0967-774X

Alan Carson (A)

Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK.

Ed Bullmore (E)

Wolfson Brain Imaging Centre, Department of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Department of Psychiatry, Institute of Behavioural and Clinical Neuroscience, University of Cambridge, Cambridge, UK.

Gerome Breen (G)

Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
NIHR Maudsley Biomedical Research Centre for Mental Health, South London and Maudsley NHS Foundation Trust, London, UK.
ORCID: 0000-0003-2053-1792

Adam Hampshire (A)

Department of Neuroimaging, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
Department of Brain Sciences, Faculty of Medicine, Imperial College London, London, UK.

Benedict D Michael (BD)

Department of Clinical Infection, Microbiology & Immunology, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. benmic@liverpool.ac.uk.
NIHR Health Protection Research Unit (HPRU) in Emerging and Zoonotic Infections, Institute of Infection, Veterinary and Ecological Sciences, University of Liverpool, Liverpool, UK. benmic@liverpool.ac.uk.
Department of Neurology, Walton Centre Foundation Trust, Liverpool, UK. benmic@liverpool.ac.uk.
ORCID: 0000-0002-8693-8926

Stella-Maria Paddick (SM)

Translational and Clinical Research Institute, Newcastle University, Newcastle, UK.
Department of Old Age Psychiatry, Gateshead Health NHS Foundation Trust, Gateshead, UK.
Millenium Institute for Care Research (MICARE), Santiago, Chile.

E Charles Leek (EC)

Department of Psychology, Institute of Population Health, Institute of Life and Human Sciences, University of Liverpool, Liverpool, UK.
School of Psychology, University of Southampton, Southampton, UK.

Classifications MeSH