Benzenesulfonohydrazide-tethered non-fused and fused heterocycles as potential anti-mycobacterial agents targeting enoyl acyl carrier protein reductase (InhA) with antibiofilm activity.


Journal

RSC advances
ISSN: 2046-2069
Titre abrégé: RSC Adv
Pays: England
ID NLM: 101581657

Informations de publication

Date de publication:
18 Sep 2024
Historique:
received: 02 08 2024
accepted: 09 09 2024
medline: 24 9 2024
pubmed: 24 9 2024
entrez: 24 9 2024
Statut: epublish

Résumé

Because resistant variants of the disease are always emerging, tuberculosis is a global issue that affects economies. New antitubercular medications should be developed, and this can be done by inhibiting druggable targets. Enoyl acyl carrier protein (ACP) reductase (InhA) is a crucial enzyme for the survival of

Identifiants

pubmed: 39315015
doi: 10.1039/d4ra05616g
pii: d4ra05616g
pmc: PMC11418391
doi:

Types de publication

Journal Article

Langues

eng

Pagination

30165-30179

Informations de copyright

This journal is © The Royal Society of Chemistry.

Déclaration de conflit d'intérêts

No potential conflicts of interest was reported by the author(s).

Auteurs

Tarfah Al-Warhi (T)

Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University Riyadh Saudi Arabia.

Ahmed Sabt (A)

Chemistry of Natural Compounds Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre Dokki Cairo 12622 Egypt.

Małgorzata Korycka-Machala (M)

Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences Lodz Poland jdziadek@cbm.pan.pl.

Asmaa F Kassem (AF)

Department of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University Al-Kharj 11942 Saudi Arabia.

Moataz A Shaldam (MA)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt wagdy2000@gmail.com.

Hoda Atef Abdelsattar Ibrahim (HAA)

Pediatric Department, Faculty of Medicine, Cairo University Cairo Egypt.

Malwina Kawka (M)

Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz Lodz Poland.

Bożena Dziadek (B)

Department of Molecular Microbiology, Faculty of Biology and Environmental Protection, University of Lodz Lodz Poland.

Magdalena Kuzioła (M)

Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences Lodz Poland jdziadek@cbm.pan.pl.
Bio-Med-Chem Doctoral School of the University of Lodz and Lodz Institutes of the Polish Academy of Sciences Lodz Poland.

Wagdy M Eldehna (WM)

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University Kafrelsheikh 33516 Egypt wagdy2000@gmail.com.
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Pharos University in Alexandria Canal El Mahmoudia St. Alexandria 21648 Egypt.

Jarosław Dziadek (J)

Laboratory of Genetics and Physiology of Mycobacterium, Institute of Medical Biology of the Polish Academy of Sciences Lodz Poland jdziadek@cbm.pan.pl.

Classifications MeSH