The markers of the predictive DNA test for canine hip dysplasia may have a stronger relationship with elbow dysplasia.
Dog
Elbow dysplasia
FRET probes
Hip dysplasia
In silico
SNP
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
30 Sep 2024
30 Sep 2024
Historique:
received:
12
01
2024
revised:
03
09
2024
accepted:
09
09
2024
medline:
24
9
2024
pubmed:
24
9
2024
entrez:
24
9
2024
Statut:
epublish
Résumé
Canine hip and elbow dysplasias, which are prevalent orthopedic conditions rooted in developmental and hereditary factors are yet to be comprehensively assessed. This study aimed to address this gap by exploring the prognostic significance of five markers linked to canine hip dysplasia using available genome-wide association studies (GWAS) data. The influence of these markers on both hip and elbow dysplasia was examined in dogs exposed to standardized environmental conditions. We made a groundbreaking discovery using custom primers, qPCR assays, and evaluation of fluorescent resonance energy transfer (FRET) probes. Three specific SNPs previously associated with the risk of canine hip dysplasia demonstrated a potentially stronger correlation with elbow dysplasia. Notably, the SNP at nucleotide position 22691322, located near the canine
Identifiants
pubmed: 39315210
doi: 10.1016/j.heliyon.2024.e37716
pii: S2405-8440(24)13747-4
pmc: PMC11417230
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e37716Informations de copyright
© 2024 The Authors.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.