The markers of the predictive DNA test for canine hip dysplasia may have a stronger relationship with elbow dysplasia.

Dog Elbow dysplasia FRET probes Hip dysplasia In silico SNP

Journal

Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560

Informations de publication

Date de publication:
30 Sep 2024
Historique:
received: 12 01 2024
revised: 03 09 2024
accepted: 09 09 2024
medline: 24 9 2024
pubmed: 24 9 2024
entrez: 24 9 2024
Statut: epublish

Résumé

Canine hip and elbow dysplasias, which are prevalent orthopedic conditions rooted in developmental and hereditary factors are yet to be comprehensively assessed. This study aimed to address this gap by exploring the prognostic significance of five markers linked to canine hip dysplasia using available genome-wide association studies (GWAS) data. The influence of these markers on both hip and elbow dysplasia was examined in dogs exposed to standardized environmental conditions. We made a groundbreaking discovery using custom primers, qPCR assays, and evaluation of fluorescent resonance energy transfer (FRET) probes. Three specific SNPs previously associated with the risk of canine hip dysplasia demonstrated a potentially stronger correlation with elbow dysplasia. Notably, the SNP at nucleotide position 22691322, located near the canine

Identifiants

pubmed: 39315210
doi: 10.1016/j.heliyon.2024.e37716
pii: S2405-8440(24)13747-4
pmc: PMC11417230
doi:

Types de publication

Journal Article

Langues

eng

Pagination

e37716

Informations de copyright

© 2024 The Authors.

Déclaration de conflit d'intérêts

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Sena Ardicli (S)

Bursa Uludag University, Faculty of Veterinary Medicine, Department of Genetics, Bursa, Turkey.
Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Pelin Yigitgor (P)

Bursa Uludag University, Faculty of Veterinary Medicine, Department of Surgery, Bursa, Turkey.

Huseyn Babayev (H)

Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland.

Dogukan Ozen (D)

Ankara University, Faculty of Veterinary Medicine, Department of Biostatistics, Ankara, Turkey.

Berkay Bozkurt (B)

Department of Biotechnology and Bioengineering, Graduate School of Science and Engineering, Izmir Institute of Technology, Izmir, Turkey.

Nursen Senturk (N)

Bursa Uludag University, Faculty of Veterinary Medicine, Department of Genetics, Bursa, Turkey.

Mehmet Pilli (M)

Near East University, Faculty of Veterinary Medicine, Department of Surgery, Nicosia, Cyprus.

Hakan Salci (H)

Bursa Uludag University, Faculty of Veterinary Medicine, Department of Surgery, Bursa, Turkey.

Deniz Seyrek Intas (D)

Near East University, Faculty of Veterinary Medicine, Department of Surgery, Nicosia, Cyprus.

Classifications MeSH