Role of Exercise on Neuropathic Pain in Preclinical Models: Perspectives for Neuroglia.
Astrocytes
Exercise
Intervention mechanisms
Microglia
Neuropathic pain
Journal
Molecular neurobiology
ISSN: 1559-1182
Titre abrégé: Mol Neurobiol
Pays: United States
ID NLM: 8900963
Informations de publication
Date de publication:
24 Sep 2024
24 Sep 2024
Historique:
received:
03
11
2023
accepted:
15
09
2024
medline:
24
9
2024
pubmed:
24
9
2024
entrez:
24
9
2024
Statut:
aheadofprint
Résumé
The benefits of exercise on neuropathic pain (NP) have been demonstrated in numerous studies. In recent studies, inflammation, neurotrophins, neurotransmitters, and endogenous opioids are considered as the main mechanisms. However, the role of exercise in alleviating NP remains unclear. Neuroglia, widely distributed in both the central and peripheral nervous systems, perform functions such as support, repair, immune response, and maintenance of normal neuronal activity. A large number of studies have shown that neuroglia play an important role in the occurrence and development of NP, and exercise can alleviate NP by regulating neuroglia. This article reviewed the involvement of neuroglia in the development of NP and their role in the exercise treatment of NP, intending to provide a theoretical basis for the exercise treatment strategy of NP.
Identifiants
pubmed: 39316356
doi: 10.1007/s12035-024-04511-y
pii: 10.1007/s12035-024-04511-y
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Natural Science Foundation of Jiangsu Province
ID : BK20210907
Organisme : Jiangsu Commission of Health
ID : Z2022004
Organisme : Xuzhou Medical University
ID : D2020056
Informations de copyright
© 2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
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