Dual ablation of the RyR2-Ser2808 and RyR2-Ser2814 sites increases propensity for pro-arrhythmic spontaneous Ca
Ca2+‐induced Ca2+ release
cardiac muscle
dephosphorylation
excitation–contraction coupling
protein phosphatase
ryanodine receptor 2
Journal
The Journal of physiology
ISSN: 1469-7793
Titre abrégé: J Physiol
Pays: England
ID NLM: 0266262
Informations de publication
Date de publication:
24 Sep 2024
24 Sep 2024
Historique:
received:
20
03
2024
accepted:
21
08
2024
medline:
24
9
2024
pubmed:
24
9
2024
entrez:
24
9
2024
Statut:
aheadofprint
Résumé
During exercise or stress, the sympathetic system stimulates cardiac contractility via β-adrenergic receptor (β-AR) activation, resulting in phosphorylation of the cardiac ryanodine receptor (RyR2). Three RyR2 phosphorylation sites have taken prominence in excitation-contraction coupling: S2808 and S2030 are described as protein kinase A specific and S2814 as a Ca
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Swiss National Science Foundation
ID : 31003A-179325
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 310030-185211
Pays : Switzerland
Organisme : Swiss National Science Foundation
ID : 310030-156375
Pays : Switzerland
Organisme : NIH HHS
ID : R01HL055438
Pays : United States
Organisme : NIH HHS
ID : R01HL161070
Pays : United States
Organisme : NIH HHS
ID : R01HL167195
Pays : United States
Organisme : NIH HHS
ID : R01HL170144
Pays : United States
Organisme : Novartis Foundation
Informations de copyright
© 2024 The Author(s). The Journal of Physiology published by John Wiley & Sons Ltd on behalf of The Physiological Society.
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