Characterization of additive gene-environment interactions for colorectal cancer risk.

Journal

Epidemiology (Cambridge, Mass.)
ISSN: 1531-5487
Titre abrégé: Epidemiology
Pays: United States
ID NLM: 9009644

Informations de publication

Date de publication:
24 Sep 2024
Historique:
medline: 24 9 2024
pubmed: 24 9 2024
entrez: 24 9 2024
Statut: aheadofprint

Résumé

Colorectal cancer (CRC) is a common, fatal cancer. Identifying subgroups who may benefit more from intervention is of critical public health importance. Previous studies have assessed multiplicative interaction between genetic risk scores and environmental factors, but few have assessed additive interaction, the relevant public health measure. Using resources from colorectal cancer consortia including 45,247 CRC cases and 52,671 controls, we assessed multiplicative and additive interaction (relative excess risk due to interaction, RERI) using logistic regression between 13 harmonized environmental factors and genetic risk score including 141 variants associated with CRC risk. There was no evidence of multiplicative interaction between environmental factors and genetic risk score. There was additive interaction where, for individuals with high genetic susceptibility, either heavy drinking [RERI = 0.24, 95% confidence interval, CI, (0.13, 0.36)], ever smoking [0.11 (0.05, 0.16)], high BMI [female 0.09 (0.05, 0.13), male 0.10 (0.05, 0.14)], or high red meat intake [highest versus lowest quartile 0.18 (0.09, 0.27)] was associated with excess CRC risk greater than that for individuals with average genetic susceptibility. Conversely, we estimate those with high genetic susceptibility may benefit more from reducing CRC risk with aspirin/NSAID use [-0.16 (-0.20, -0.11)] or higher intake of fruit, fiber, or calcium [highest quartile versus lowest quartile -0.12 (-0.18, -0.050); -0.16 (-0.23, -0.09); -0.11 (-0.18, -0.05), respectively] than those with average genetic susceptibility. Additive interaction is important to assess for identifying subgroups who may benefit from intervention. The subgroups identified in this study may help inform precision CRC prevention.

Sections du résumé

BACKGROUND BACKGROUND
Colorectal cancer (CRC) is a common, fatal cancer. Identifying subgroups who may benefit more from intervention is of critical public health importance. Previous studies have assessed multiplicative interaction between genetic risk scores and environmental factors, but few have assessed additive interaction, the relevant public health measure.
METHODS METHODS
Using resources from colorectal cancer consortia including 45,247 CRC cases and 52,671 controls, we assessed multiplicative and additive interaction (relative excess risk due to interaction, RERI) using logistic regression between 13 harmonized environmental factors and genetic risk score including 141 variants associated with CRC risk.
RESULTS RESULTS
There was no evidence of multiplicative interaction between environmental factors and genetic risk score. There was additive interaction where, for individuals with high genetic susceptibility, either heavy drinking [RERI = 0.24, 95% confidence interval, CI, (0.13, 0.36)], ever smoking [0.11 (0.05, 0.16)], high BMI [female 0.09 (0.05, 0.13), male 0.10 (0.05, 0.14)], or high red meat intake [highest versus lowest quartile 0.18 (0.09, 0.27)] was associated with excess CRC risk greater than that for individuals with average genetic susceptibility. Conversely, we estimate those with high genetic susceptibility may benefit more from reducing CRC risk with aspirin/NSAID use [-0.16 (-0.20, -0.11)] or higher intake of fruit, fiber, or calcium [highest quartile versus lowest quartile -0.12 (-0.18, -0.050); -0.16 (-0.23, -0.09); -0.11 (-0.18, -0.05), respectively] than those with average genetic susceptibility.
CONCLUSIONS CONCLUSIONS
Additive interaction is important to assess for identifying subgroups who may benefit from intervention. The subgroups identified in this study may help inform precision CRC prevention.

Identifiants

DOI: 10.1097/EDE.0000000000001795 PMID: 39316822
pubmed: 39316822
doi: 10.1097/EDE.0000000000001795
pii: 00001648-990000000-00298
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.

Déclaration de conflit d'intérêts

Conflict of Interest: SB Gruber: Brogent International LLC, co-founder, not related to submitted work. All other authors do not have any conflicts of interest to disclose.

Auteurs

Claire E Thomas (CE)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Yi Lin (Y)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Michelle Kim (M)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Eric S Kawaguchi (ES)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Conghui Qu (C)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Caroline Y Um (CY)

Department of Population Science, American Cancer Society, Atlanta, Georgia.

Brigid M Lynch (BM)

Cancer Epidemiology Division, Cancer Council Victoria, Melbourne, Victoria, Australia.
Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia.

Bethany Van Guelpen (B)

Department of Radiation Sciences, Oncology Unit, Umeå University, Umeå, Sweden.
Wallenberg Centre for Molecular Medicine, Umeå University, Umeå, Sweden.

Kostas Tsilidis (K)

Department of Epidemiology and Biostatistics, Imperial College London, School of Public Health, London, UK.
Department of Hygiene and Epidemiology, University of Ioannina, School of Medicine, Ioannina, Greece.

Robert Carreras-Torres (R)

Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, 8908 Barcelona, Spain.
Digestive Diseases and Microbiota Group, Girona Biomedical Research Institute (IDIBGI), Salt, 17190, Girona, Spain.

Franzel Jb van Duijnhoven (FJ)

Division of Human Nutrition and Health, Wageningen University & Research, Wageningen, The Netherlands.

Lori C Sakoda (LC)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Division of Research, Kaiser Permanente Northern California, Oakland, California, USA.

Peter T Campbell (PT)

Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.

Yu Tian (Y)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
School of Public Health, Capital Medical University, Beijing, China.

Jenny Chang-Claude (J)

Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
University Medical Centre Hamburg-Eppendorf, University Cancer Centre Hamburg (UCCH), Hamburg, Germany.

Stéphane Bézieau (S)

Service de Génétique Médicale, Centre Hospitalier Universitaire (CHU) Nantes, Nantes, France.

Arif Budiarto (A)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
Computer Science Department, School of Computer Science, Bina Nusantara University, Jakarta, Indonesia.

Julie R Palmer (JR)

Slone Epidemiology Center at Boston University, Boston, Massachusetts, USA.

Polly A Newcomb (PA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Graham Casey (G)

Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA.

Loic Le Marchand (L)

University of Hawaii Cancer Center, Honolulu, Hawaii, USA.

Marios Giannakis (M)

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Christopher I Li (CI)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Andrea Gsur (A)

Center for Cancer Research, Medical University of Vienna, Vienna, Austria.

Christina Newton (C)

Department of Population Science, American Cancer Society, Atlanta, Georgia.

Mireia Obón-Santacana (M)

Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat,Barcelona, Spain.
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.

Victor Moreno (V)

Unit of Biomarkers and Suceptibility (UBS), Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L'Hospitalet del Llobregat,Barcelona, Spain.
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Barcelona, Spain.
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain.
Department of Clinical Sciences, Faculty of Medicine and health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), University of Barcelona (UB), L'Hospitalet de Llobregat, Barcelona, Spain.

Pavel Vodicka (P)

Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic.
Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Faculty of Medicine and Biomedical Center in Pilsen, Charles University, Pilsen, Czech Republic.

Hermann Brenner (H)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Division of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, Germany.
German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.

Michael Hoffmeister (M)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Andrew J Pellatt (AJ)

Department of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, USA.

Robert E Schoen (RE)

Departments of Medicine and Epidemiology, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.

Niki Dimou (N)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.

Neil Murphy (N)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.

Marc J Gunter (MJ)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.

Sergi Castellví-Bel (S)

Gastroenterology Department, Hospital Clínic, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHD), University of Barcelona, Barcelona, Spain.

Jane C Figueiredo (JC)

Department of Medicine, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Andrew T Chan (AT)

Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.

Mingyang Song (M)

Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.
Departments of Epidemiology and Nutrition, Harvard TH Chan School of Public Health, Boston, MA, USA.
Department of Nutrition, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.

Li Li (L)

Department of Family Medicine, University of Virginia, Charlottesville, Virginia, USA.

D Timothy Bishop (DT)

Leeds Institute of Medical Research, University of Leeds, Leeds, UK.

Stephen B Gruber (SB)

Department of Medical Oncology & Therapeutics Research, City of Hope National Medical Center, Duarte CA, USA.

James W Baurley (JW)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.
BioRealm LLC, Walnut, California, USA.

Stephanie A Bien (SA)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

David V Conti (DV)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Jeroen R Huyghe (JR)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Anshul Kundaje (A)

Department of Genetics, Stanford University, Stanford, California, USA.
Department of Computer Science, Stanford University, Stanford, California, USA.

Yu-Ru Su (YR)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Jun Wang (J)

Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, USA.

Temitope O Keku (TO)

Center for Gastrointestinal Biology and Disease, University of North Carolina, Chapel Hill, North Carolina, USA.

Michael O Woods (MO)

Memorial University of Newfoundland, Discipline of Genetics, St. John's, Canada.

Sonja I Berndt (SI)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Stephen J Chanock (SJ)

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.

Catherine M Tangen (CM)

SWOG Statistical Center, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Alicja Wolk (A)

Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.

Andrea Burnett-Hartman (A)

Institute for Health Research, Kaiser Permanente Colorado, Aurora, Colorado, USA.

Anna H Wu (AH)

University of Southern California, Department of Population and Public Health Sciences, Los Angeles, California, USA.

Emily White (E)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA.

Matthew A Devall (MA)

Department of Family Medicine, University of Virginia, Charlottesville, Virginia, USA.

Virginia Díez-Obrero (V)

Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Denmark.

David A Drew (DA)

Clinical & Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

Edward Giovannucci (E)

Harvard TH Chan School of Public Health.
Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA.

Akihisa Hidaka (A)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.

Andre E Kim (AE)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Juan Pablo Lewinger (JP)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

John Morrison (J)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Jennifer Ose (J)

Huntsman Cancer Institute, Salt Lake City, Utah, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA.

Nikos Papadimitriou (N)

Nutrition and Metabolism Branch, International Agency for Research on Cancer, Lyon, France.

Bens Pardamean (B)

Bioinformatics and Data Science Research Center, Bina Nusantara University, Jakarta, Indonesia.

Anita R Peoples (AR)

Huntsman Cancer Institute, Salt Lake City, Utah, USA.; Department of Population Health Sciences, University of Utah, Salt Lake City, Utah, USA.

Edward A Ruiz-Narvaez (EA)

Department of Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, Michigan, USA.

Anna Shcherbina (A)

Department of Genetics, Stanford University, Stanford, California, USA.
Department of Computer Science, Stanford University, Stanford, California, USA.

Mariana C Stern (MC)

Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Xuechen Chen (X)

Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Duncan C Thomas (DC)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Elizabeth A Platz (EA)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA.

W James Gauderman (WJ)

Division of Biostatistics, Department of Population and Public Health Sciences, Keck School of Medicine, University of Southern California, Los Angeles, California, USA.

Ulrike Peters (U)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Department of Epidemiology, University of Washington, Seattle, Washington, USA.

Li Hsu (L)

Public Health Sciences Division, Fred Hutchinson Cancer Center, Seattle, Washington, USA.
Department of Biostatistics, University of Washington, Seattle, Washington, USA.

Classifications MeSH