Discovering the anti-diabetic potential of pomegranate peel metabolites by examining molecular interplay with the thioredoxin-interacting protein.

Punica granatum Staphylococcus viridans TXNIP biological activities diabetes phytochemicals

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2023
Historique:
received: 16 10 2023
accepted: 18 12 2023
medline: 25 9 2024
pubmed: 25 9 2024
entrez: 25 9 2024
Statut: epublish

Résumé

Medicinal plants like Punica granatum (pomegranate) have traditional uses against diabetes, inflammation and other diseases. The study was initiated to get an insight into the interaction tendency of To elucidate the therapeutic potential of The peel exhibited antioxidant, anti-inflammatory and anti-diabetic activities, which were attributed to phytochemicals like phenols, tannins and steroids. GC-MS analysis identified 3,5-octadien-2-one, 1H-pyrrole -2,5-dione, Beta-D-lyxofuranoside, 5-O-(beta-D-lyxofuranosyl)-decyl, diethyl phthalate, 9-octadecenoic acid (Z)-, methyl ester, hexadecanoic acid, methyl ester, n-hexadecanoic acid, tetradecane, 2,6,10-trimethyl, bis (2-ethylhexyl) phthalate, decane, 3,8-dimethyl, 9-octadecenoic acid (Z)-, methyl ester and bis (2-ethylhexyl) phthalate in

Identifiants

pubmed: 39319322
doi: 10.3389/fmed.2023.1322450
pmc: PMC11421477
doi:

Types de publication

Journal Article

Langues

eng

Pagination

1322450

Informations de copyright

Copyright © 2024 Aslam, Arif, Arshad, Muccee, Ahmad, Iqbal, Khalil, Razak, Afsar, Almajwal, Shafique and Zain.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Auteurs

Tahira Aslam (T)

Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.

Amina Arif (A)

Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.

Shafia Arshad (S)

University College of Conventional Medicine, Faculty of Medicine and allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Fatima Muccee (F)

School of Biochemistry and Biotechnology, University of Punjab, Lahore, Pakistan.

Khalil Ahmad (K)

University College of Conventional Medicine, Faculty of Medicine and allied Health Sciences, The Islamia University of Bahawalpur, Bahawalpur, Pakistan.

Muhammad Omer Iqbal (MO)

Key Laboratory of Marine Drugs, the Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao, China.

Umair Khalil (U)

Department of Basic and Applied Chemistry, Faculty of Science and Technology, University of Central Punjab, Lahore, Pakistan.

Suhail Razak (S)

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Tayyaba Afsar (T)

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Ali Almajwal (A)

Department of Community Health Sciences, College of Applied Medical Sciences, King Saud University, Riyadh, Saudi Arabia.

Huma Shafique (H)

Institute of Cellular Medicine, Newcastle University Medical School, Newcastle University, Newcastle upon Tyne, United Kingdom.

Maryam Zain (M)

Department of Biochemistry and Biotechnology, The Women University Multan, Multan, Pakistan.

Classifications MeSH