Environmental study and stress-related biomarkers modifications in a crew during analog astronaut mission EMMPOL 6.
Confinement
Cortisol
Non-invasive methods
Oxy-inflammation
Space exploration
Journal
European journal of applied physiology
ISSN: 1439-6327
Titre abrégé: Eur J Appl Physiol
Pays: Germany
ID NLM: 100954790
Informations de publication
Date de publication:
25 Sep 2024
25 Sep 2024
Historique:
received:
02
10
2023
accepted:
12
08
2024
medline:
25
9
2024
pubmed:
25
9
2024
entrez:
25
9
2024
Statut:
aheadofprint
Résumé
Human presence in space is increasingly frequent, but we must not forget that it is a hostile environment. We aimed to study the characteristics of experimental scenarios, to obtain data on human response to isolation, disruption of circadian rhythm and high levels of psychophysical stress. In these experiments, we evaluated stress response in five young healthy subjects inside an earth-based moon-settlement-like habitat during a 1-week long analog astronaut mission. Wearable devices were used to monitor daily step count of the subjects, physical activity, heart rate during physical exercise and at rest, and sleep parameters. From saliva and urine samples collected every day at awakening, we studied oxy-inflammation biomarkers and hormones (stress and appetite) were studied too. At the end of the week, all subjects revealed an increase in oxidative stress and cortisol levels but no inflammation biomarkers variations, in conjunction with increasing time/daily exercise. Furthermore, a significant decrease in hours of sleep/day, sleep quality, and REM phase of sleep was recorded and correlated with the increase of reactive oxygen species. Oxidative stress increased in a short period of time and may be attributed to the influence of psychological stress during confinement, as well as increased exercise and decreased amount of sleep. On a long-term basis, this could impact performance.
Identifiants
pubmed: 39320485
doi: 10.1007/s00421-024-05575-3
pii: 10.1007/s00421-024-05575-3
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Bird
ID : SP BIRD 204020
Informations de copyright
© 2024. The Author(s).
Références
Alhola P, Polo-Kantola P (2007) Sleep deprivation: impact on cognitive performance. Neuropsychiatr Dis Treat 3(5):553–567
pubmed: 19300585
pmcid: 2656292
Baglioni C, Battagliese G, Feige B et al (2011) Insomnia as a predictor of depression: a meta-analytic evaluation of longitudinal epidemiological studies. J Affect Disord. https://doi.org/10.1016/j.jad.2011.01.011
doi: 10.1016/j.jad.2011.01.011
pubmed: 21300408
Bartone PT, Krueger GP, Bartone JV (2018) Individual differences in adaptability to isolated, confined, and extreme environments. Aerosp Med Hum Perform 89(6):536–546. https://doi.org/10.3357/AMHP.4951.2018
doi: 10.3357/AMHP.4951.2018
pubmed: 29789087
Bakdash JZ, Marusich LR (2017) Repeated measures correlation. Front Psychol 8:456. https://doi.org/10.3389/fpsyg.2017.00456
doi: 10.3389/fpsyg.2017.00456
pubmed: 28439244
pmcid: 5383908
Bell ST, Brown SG, Mitchell T (2019) What we know about team dynamics for long-distance space missions: a systematic review of analog research. Front Psychol 10(MAY):1–21. https://doi.org/10.3389/fpsyg.2019.0081
doi: 10.3389/fpsyg.2019.0081
Bevere M, Di Cola G, Santangelo C (2022) Redox-based disruption of cellular hormesis and promotion of degenerative pathways: perspectives on aging processes. J Gerontol A Biol Sci Med Sci 77(11):2195–2206. https://doi.org/10.1093/gerona/glac167
doi: 10.1093/gerona/glac167
pubmed: 35973816
Bosco G, Rizzato A, Quartesan S et al (2018a) Spirometry and oxidative stress after rebreather diving in warm water. Undersea Hyperb Med 45:191–198
doi: 10.22462/03.04.2018.6
pubmed: 29734571
Bosco G, Vezzani G, Mrakic Sposta S et al (2018b) Hyperbaric oxygen therapy ameliorates osteonecrosis in patients by modulating inflammation and oxidative stress. J Enzyme Inhib Med Chem 33(1):1501–1505. https://doi.org/10.1080/14756366.2018.1485149
doi: 10.1080/14756366.2018.1485149
pubmed: 30274530
pmcid: 6171420
Bosco G, Giacon TA, Paolocci N (2023) Dopamine/BDNF loss underscores narcosis cognitive impairment in divers: a proof of concept in a dry condition. Eur J Appl Physiol 123(1):143–158. https://doi.org/10.1007/s00421-022-05055-6
doi: 10.1007/s00421-022-05055-6
pubmed: 36214902
Bouillon-Minois JB, Trousselard M, Thivel D (2021) As a biomarker of stress: a systematic review and meta-analysis. Nutrients 13:3350. https://doi.org/10.3390/nu13103350
doi: 10.3390/nu13103350
pubmed: 34684349
pmcid: 8541372
Brizzolari A, Bosco G, Vezzoli A et al (2023) Seasonal oxy-inflammation and hydration status in non-elite Freeskiing racer: a pilot study by non-invasive analytic method. Int J Environ Res Public Health 20(4):3157. https://doi.org/10.3390/ijerph20043157
doi: 10.3390/ijerph20043157
pubmed: 36833850
pmcid: 9960265
Cappuccio FP, Cooper D, Delia L et al (2011) Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Eur Heart J. https://doi.org/10.1093/eurheartj/ehr007
doi: 10.1093/eurheartj/ehr007
pubmed: 21300732
Carbajales-Dale M, Murphy TW (2023) The environmental and moral implications of human space travel. Sci Total Environ 856(2):159222. https://doi.org/10.1016/j.scitotenv.2022.159222
doi: 10.1016/j.scitotenv.2022.159222
pubmed: 36209886
Chinoy ED, Cuellar JA, Huwa KE et al (2021) Performance of seven consumer sleep-tracking devices compared with polysomnography. Sleep 44(5):1–16. https://doi.org/10.1093/sleep/zsaa291
doi: 10.1093/sleep/zsaa291
Criscuolo F, Sueur C, Bergouignan A (2020) Human adaptation to deep space environment: an evolutionary perspective of the foreseen interplanetary exploration. Front Public Heal 8:1–5. https://doi.org/10.3389/fpubh.2020.00119
doi: 10.3389/fpubh.2020.00119
Cromwell RL, Huff JL, Simonsen LC, Patel ZS (2021) Earth-based research analogs to investigate space-based health risks. New Space 9(4):204–216. https://doi.org/10.1089/space.2020.0048
doi: 10.1089/space.2020.0048
pubmed: 35024249
pmcid: 8743922
Dellanoce C, Cozzi L, Zuddas S et al (2014) Determination of different forms of aminothiols in red blood cells without washing erythrocytes. Biomed Chromatogr 28:327–331. https://doi.org/10.1002/bmc.3056
doi: 10.1002/bmc.3056
pubmed: 24132697
Demontis GC, Germani MM, Caiani EG et al (2017) Human pathophysiological adaptations to the space environment. Front Physiol 8:1–17. https://doi.org/10.3389/fphys.2017.00547
doi: 10.3389/fphys.2017.00547
Düking P, Giessing L, Frenkel MO et al (2020) Wrist-worn wearables for monitoring heart rate and energy expenditure while sitting or performing light-to-vigorous physical activity: validation study. JMIR mHealth uHealth 8(5):1–13. https://doi.org/10.2196/16716
doi: 10.2196/16716
Faraut B, Boudjeltia KZ, Vanhamme L, Kerkhofs M (2012) Immune, inflammatory and cardiovascular consequences of sleep restriction and recovery. Sleep Med Rev 16:137–149. https://doi.org/10.1016/j.smrv.2011.05.001
doi: 10.1016/j.smrv.2011.05.001
pubmed: 21835655
Ferrie JE, Kivimaki M, Akbaraly TN et al (2013) Associations between change in sleep duration and inflammation: findings on C-reactive protein and interleukin 6 in the Whitehall II Study. Am J Epidemiol 178:956–961. https://doi.org/10.1093/aje/kwt072
doi: 10.1093/aje/kwt072
pubmed: 23801012
pmcid: 3817449
Gallicchio L, Kalesan B (2009) Sleep duration and mortality: a systematic review and meta-analysis. J Sleep Res 18:148–158. https://doi.org/10.1111/j.1365-2869.2008.00732.x
doi: 10.1111/j.1365-2869.2008.00732.x
pubmed: 19645960
Giacon TA, Bosco G, Vezzoli A et al (2022) Oxidative stress and motion sickness in one crew during competitive offshore sailing. Sci Rep 12(1):1142. https://doi.org/10.1038/s41598-022-05219-6
doi: 10.1038/s41598-022-05219-6
pubmed: 35064225
pmcid: 8782845
Gieseg SP, Baxter-Parker G, Lindsay A (2018) Neopterin, inflammation, and oxidative stress: what could we be missing? Antioxidants (Basel) 7(7):80. https://doi.org/10.3390/antiox7070080
doi: 10.3390/antiox7070080
pubmed: 29949851
Glantzounis G, Tsimoyiannis E, Kappas A, Galaris D (2005) Uric acid and oxidative stress. Curr Pharm Des 11(32):4145–4151. https://doi.org/10.2174/138161205774913255
doi: 10.2174/138161205774913255
pubmed: 16375736
Gunnarsson LG, Bäck H, Jones I, Olsson T (2004) Stress recovery during an ocean boat race. Stress Health 20(3):165–171. https://doi.org/10.1002/smi.1008
doi: 10.1002/smi.1008
Guo JH, Ma XH, Ma H et al (2020) Circadian misalignment on submarines and other non-24-h environments—from research to application. Milit Med Res 7(1):1–12
Hajam YA, Rani R, Ganie SY et al (2022) Oxidative stress in human pathology and aging: molecular mechanisms and perspectives. Cells 11:552. https://doi.org/10.3390/cells11030552
doi: 10.3390/cells11030552
pubmed: 35159361
pmcid: 8833991
Hill VM, O’Connor RM, Sissoko GB et al (2018) A bidirectional relationship between sleep and oxidative stress in Drosophila. PLoS Biol 16(7):e2005206. https://doi.org/10.1371/journal.pbio.2005206
doi: 10.1371/journal.pbio.2005206
pubmed: 30001323
pmcid: 6042693
Hublin C, Partinen M, Koskenvuo M, Kaprio J (2007) Sleep and mortality: a population-based 22-year follow-up study. Sleep. 30(10):1245–53. https://doi.org/10.1093/sleep/30.10.1245
doi: 10.1093/sleep/30.10.1245
pubmed: 17969458
pmcid: 2266277
Koschate J, Drescher U, Hoffmann U (2021) Confinement, partial sleep deprivation and defined physical activity—influence on cardiorespiratory regulation and capacity. Eur J Appl Physiol 121(9):2521–2530. https://doi.org/10.1007/s00421-021-04719-z
doi: 10.1007/s00421-021-04719-z
pubmed: 34080066
pmcid: 8357778
Johnson AN, Clockston RLM et al (2023) Changes in adults’ eating behaviors during the initial months of the COVID-19 pandemic: a narrative review. J Acad Nutr Diet 123(1):144-194.e30. https://doi.org/10.1016/j.jand.2022.08.132
doi: 10.1016/j.jand.2022.08.132
pubmed: 36075551
Juan CA, Pérezdela Lastra JM, Plou FJ et al (2021) The chemistry of reactive oxygen species (ROS) revisited: outlining their role in biological macromolecules (DNA, lipids and proteins) and induced pathologies. Int J Mol Sci 22:4642. https://doi.org/10.3390/ijms22094642
doi: 10.3390/ijms22094642
pubmed: 33924958
pmcid: 8125527
Izmailova ES, Wagner JA, Perakslis ED (2018) Wearable devices in clinical trials: hype and hypothesis. Clin Pharmacol Ther 104(1):42–52. https://doi.org/10.1002/cpt.966
doi: 10.1002/cpt.966
pubmed: 29205294
pmcid: 6032822
Leach J (2016) Psychological factors in exceptional, extreme and torturous environments. Extrem Physiol Med. 5:7. https://doi.org/10.1186/s13728-016-0048-y
doi: 10.1186/s13728-016-0048-y
pubmed: 27257476
pmcid: 4890253
Lightman SL, Birnie MT, Conway-Campbell BL (2021) Dynamics of ACTH and cortisol secretion and implications for disease. Endocr Rev 41(3):470–490. https://doi.org/10.1210/endrev/bnaa002
doi: 10.1210/endrev/bnaa002
Lauterbach CJ, Romano PA, Greisler LA et al (2020) Accuracy and reliability of commercial wrist-worn pulse oximeter during normobaric hypoxia exposure under resting conditions. Res Q Exerc Sport [internet] 00(00):1–10. https://doi.org/10.1080/02701367.2020.1759768
doi: 10.1080/02701367.2020.1759768
John L (2016) Psychological factors in exceptional, extreme and torturous environments. Extrem Physiol Med 5:7. https://doi.org/10.1186/s13728-016-0048-y
doi: 10.1186/s13728-016-0048-y
Liu Y, Wheaton AG, Chapman DP et al (2016) Prevalence of healthy sleep duration among adults—United States, 2014. MMWR Morb Mortal Wkly Rep 65:137–141. https://doi.org/10.15585/mmwr.mm6506a1
doi: 10.15585/mmwr.mm6506a1
pubmed: 26890214
Micarelli A, Mrakic-Sposta S, Micarelli B et al (2022) Smell impairment in stage I–II obesity: correlation with biochemical regulators and clinical aspects. Laryngoscope 132(10):2028–2035. https://doi.org/10.1002/lary.30325
doi: 10.1002/lary.30325
pubmed: 35906890
Micarelli A, Vezzoli A, Malacrida S et al (2023) Taste function in adult humans from lean condition to stage II obesity: interactions with biochemical regulators, dietary habits, and clinical aspects. Nutrients 15(5):1114. https://doi.org/10.3390/nu15051114
doi: 10.3390/nu15051114
pubmed: 36904115
pmcid: 10005537
Moretti S, Mrakic-Sposta S, Roncoroni L et al (2018) Oxidative stress as a biomarker for monitoring treated celiac disease. Clin Transl Gastroenterol 9(6):157. https://doi.org/10.1038/s41424-018-0031-6
doi: 10.1038/s41424-018-0031-6
pubmed: 29880904
pmcid: 5992147
Mrakic-Sposta S, Gussoni M, Montorsi M et al (2014) A quantitative method to monitor reactive oxygen species production by electron paramagnetic resonance in physiological and pathological conditions. Oxid Med Cell Longev 2014:306179. https://doi.org/10.1155/2014/306179
doi: 10.1155/2014/306179
pubmed: 25374651
pmcid: 4211297
Mrakic-Sposta S, Gussoni M, Moretti S et al (2015) Effects of mountain ultra-marathon running on ROS production and oxidative damage by micro-invasive analytic techniques. PLoS ONE 10(11):e0141780. https://doi.org/10.1371/journal.pone.0141780
doi: 10.1371/journal.pone.0141780
pubmed: 26540518
pmcid: 4634988
Mrakic-Sposta S, Vezzoli A, Rizzato A et al (2019) Oxidative stress assessment in breath-hold diving. Eur J Appl Physiol 119:2449–2456. https://doi.org/10.1007/s00421-019-04224-4
doi: 10.1007/s00421-019-04224-4
pubmed: 31520216
Mrakic-Sposta S, Vezzoli A, D’Alessandro F et al (2020) Change in oxidative stress biomarkers during 30 days in saturation dive: a pilot study. Int J Environ Res Public Health 17(19):1–11. https://doi.org/10.3390/ijerph17197118
doi: 10.3390/ijerph17197118
Mrakic-Sposta S, Montorsi M, Porcelli S et al (2022) A. Effects of prolonged exposure to hypobaric hypoxia on oxidative stress: overwintering in Antarctic Concordia station. Oxid Med Cell Longev 2022:4430032. https://doi.org/10.1155/2022/4430032
doi: 10.1155/2022/4430032
pubmed: 35535360
pmcid: 9078816
Muid S, Abu Makar NS, Abdul Rahman T et al (2019) Effects of prolonged isolation in a confined space on status of oxidative stress and prothrombogenesis: in preparation for possible future manned space expedition to Mars. Malays J Pathol 41(3):283–292
pubmed: 31901913
NASA Analog Missions (2024). https://www.nasa.gov/analog-missions/ . https://www.nasa.gov/missions/analog-field-testing/chapea/first-nasa-mars-analog-crew-nears-end-of-mission/
Navalta JW, Montes J, Bodell NG et al (2020) Concurrent heart rate validity of wearable technology devices during trail running. PLoS One [internet] 15(8):1–11. https://doi.org/10.1371/journal.pone.0238569
doi: 10.1371/journal.pone.0238569
Nedeltcheva AV, Scheer FAJL (2014) Metabolic effects of sleep disruption, links to obesity and diabetes. Curr Opin Endocrinol Diabetes Obes 21:293–298. https://doi.org/10.1097/MED.0000000000000082
doi: 10.1097/MED.0000000000000082
pubmed: 24937041
pmcid: 4370346
Nicogossian AE, Pober DF, Roy SA (2001) Evolution of telemedicine in the space program and earth applications. Telemed J e-Health 7(1):1–15. https://doi.org/10.1089/153056201300093813
doi: 10.1089/153056201300093813
pubmed: 11321704
Osborne BB, Bestelmeyer BT, Currier CM et al (2022) The consequences of climate change for dryland biogeochemistry. New Phytol 236(1):15–20. https://doi.org/10.1111/nph.18312
doi: 10.1111/nph.18312
pubmed: 35706381
Pasca R, Wagner SL (2011) Occupational stress in the multicultural workplace. J Immigr Minor Heal 13(4):697–705. https://doi.org/10.1007/s10903-011-9457-6
doi: 10.1007/s10903-011-9457-6
Pizzino G, Irrera N, Cucinotta M et al (2017) Oxidative stress: harms and benefits for human health. Oxid Med Cell Longev 2017:8416763. https://doi.org/10.1155/2017/8416763
doi: 10.1155/2017/8416763
pubmed: 28819546
pmcid: 5551541
Powers SK, Radak Z, Ji LL (2016) Exercise-induced oxidative stress: past, present and future. J Physiol 594(18):5081–5092. https://doi.org/10.1113/JP270646
doi: 10.1113/JP270646
pubmed: 26893258
pmcid: 5023699
Reimund E (1944) The free radical flux theory of sleep. Med Hypotheses 43:231–233. https://doi.org/10.1016/0306-9877(94)90071-X
doi: 10.1016/0306-9877(94)90071-X
Whirledge S, Cidlowski JA (2010) Glucocorticoids, stress, and fertility. Minerva Endocrinol 35(2):109–125
pubmed: 20595939
pmcid: 3547681
Vernikos J, Schneider VS (2010) Space, gravity and the physiology of aging: parallel or convergent disciplines? A mini-review. Gerontology 56(2):157–166. https://doi.org/10.1159/000252852
doi: 10.1159/000252852
pubmed: 19851058
Vezzoli A, Dellanoce C, Mrakic-Sposta S et al (2016) Oxidative stress assessment in response to ultraendurance exercise: thiols redox status and ROS production according to duration of a competitive race. Oxid Med Cell Longev 2016:6439037. https://doi.org/10.1155/2016/6439037
doi: 10.1155/2016/6439037
pubmed: 27504148
pmcid: 4967677
Vezzoli A, Mrakic-Sposta S, Dellanoce C, Montorsi M, Vietti D, Ferrero ME (2023) Chelation therapy associated with antioxidant supplementation can decrease oxidative stress and inflammation in multiple sclerosis: preliminary results. Antioxidants (Basel) 12(7):1338. https://doi.org/10.3390/antiox12071338
doi: 10.3390/antiox12071338
pubmed: 37507878
Schaefer KE, Kerr CM, Buss D, Haus E (1979) Effect of 18-h watch schedules on circadian cycles of physiological functions during submarine patrols. Undersea Biomed Res 6(Suppl):S81-90
pubmed: 505631
Sies H, Jones DP (2020) Reactive oxygen species (ROS) as pleiotropic physiological signalling agents. Nat Rev Mol Cell Biol 21:363–383. https://doi.org/10.1038/s41580-020-0230-3
doi: 10.1038/s41580-020-0230-3
pubmed: 32231263
Strewe C, Moser D, Buchheim JI et al (2019) Sex differences in stress and immune responses during confinement in Antarctica. Biol Sex Differ 10(1):1–17. https://doi.org/10.1186/s13293-019-0231-0
doi: 10.1186/s13293-019-0231-0
Tai JQJ, Wong SF, Chow SKM et al (2022) Assessing physical fitness of athletes in a confined environment during prolonged self-isolation: potential usefulness of the test of maximal number of burpees performed in 3 minutes. Int J Environ Res Public Health 19:5928. https://doi.org/10.3390/ijerph19105928
doi: 10.3390/ijerph19105928
pubmed: 35627465
pmcid: 9142106
Tahara Y, Aoyama S, Shibata S (2017) The mammalian circadian clock and its entrainment by stress and exercise. J Physiol Sci 67(1):1–10. https://doi.org/10.1007/s12576-016-0450-7
doi: 10.1007/s12576-016-0450-7
pubmed: 27084533
Vallat R (2018) Pingouin: statistics in Python. J Open Source Softw 3(31):1026. https://doi.org/10.21105/joss.01026
doi: 10.21105/joss.01026
Jacubowski A, Abeln V, Vogt T et al (2015) The impact of long-term confinement and exercise on central and peripheral stress markers. Physiol Behav 152:106–111. https://doi.org/10.1016/j.physbeh.2015.09.017
doi: 10.1016/j.physbeh.2015.09.017
pubmed: 26387624
Jensen HJ, Oldenburg M (2020) Training seafarers to deal with multicultural crew members and stress on board. Int Marit Health 71(3):174–180. https://doi.org/10.5603/IMH.2020.0031
doi: 10.5603/IMH.2020.0031
pubmed: 33001428
Yau YHC, Potenza MN (2013) Stress and eating behaviors. Minerva Endocrinol 38(3):255–267
pubmed: 24126546
pmcid: 4214609
Weber J, Javelle F, Klein T et al (2019) Neurophysiological, neuropsychological, and cognitive effects of 30 days of isolation. Exp Brain Res [internet]. https://doi.org/10.1007/s00221-019-05531-0
doi: 10.1007/s00221-019-05531-0
pubmed: 30927043
Żurek J, Rudy M (2024) Impact of the COVID-19 pandemic on changes in consumer purchasing behavior in the food market with a focus on meat and meat products—a comprehensive literature review. Foods 13:933. https://doi.org/10.3390/foods13060933
doi: 10.3390/foods13060933
pubmed: 38540923
pmcid: 10969802