Kappa opioids inhibit spinal output neurons to suppress itch.

Pruritus / drug therapy Animals Receptors, Opioid, kappa / metabolism Receptors, Bombesin / metabolism Mice Morphinans / pharmacology Neurons / drug effects Spinal Cord / metabolism Spiro Compounds / pharmacology Interneurons / metabolism Male

Journal

Science advances
ISSN: 2375-2548
Titre abrégé: Sci Adv
Pays: United States
ID NLM: 101653440

Informations de publication

Date de publication:
27 Sep 2024
Historique:
medline: 25 9 2024
pubmed: 25 9 2024
entrez: 25 9 2024
Statut: ppublish

Résumé

Itch is a protective sensation that drives scratching. Although specific cell types have been proposed to underlie itch, the neural basis for itch remains unclear. Here, we used two-photon Ca

Identifiants

DOI: 10.1126/sciadv.adp6038 PMID: 39321286
pubmed: 39321286
doi: 10.1126/sciadv.adp6038
doi:

Substances chimiques

Receptors, Opioid, kappa 0
Receptors, Bombesin 0
Morphinans 0
TRK 820 25CC4N0P8J
Spiro Compounds 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

eadp6038

Auteurs

Tayler D Sheahan (TD)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0002-5015-0600

Charles A Warwick (CA)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0001-6244-9821

Abby Y Cui (AY)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0001-5333-5080

David A A Baranger (DAA)

Department of Psychological and Brain Sciences, Washington University in St. Louis, St. Louis, MO, USA.
ORCID: 0000-0002-6659-357X

Vijay J Perry (VJ)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0009-0006-8251-8103

Kelly M Smith (KM)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.

Allison P Manalo (AP)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0003-3616-5416

Eileen K Nguyen (EK)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0003-2282-4222

H Richard Koerber (HR)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.

Sarah E Ross (SE)

Pittsburgh Center for Pain Research and Department of Neurobiology, University of Pittsburgh, Pittsburgh, PA, USA.
Department of Anesthesiology, University of Pittsburgh, Pittsburgh, PA, USA.
ORCID: 0000-0003-2593-3133

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations cutanées › Prurit › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Eucaryotes › Animaux › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteurs aux opioïdes › Récepteur kappa › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs peptidiques › Récepteur aux neuropeptides › Récepteur bombésine › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Cellules › Neurones › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Système nerveux › Système nerveux central › Moelle spinale › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Composés polycycliques › Spiranes › Kappa opioids inhibit spinal output neurons to...
questionsmedicales.fr › Cellules › Neurones › Interneurones › Kappa opioids inhibit spinal output neurons to...