Patient-reported outcome measures and physical function following head and neck lymphedema - a systematic review.
Head and neck cancer
Lymphedema
Patient-reported outcomes
Physical assessments
Quality of life
Systematic review
Journal
Journal of cancer survivorship : research and practice
ISSN: 1932-2267
Titre abrégé: J Cancer Surviv
Pays: United States
ID NLM: 101307557
Informations de publication
Date de publication:
26 Sep 2024
26 Sep 2024
Historique:
received:
12
07
2024
accepted:
17
09
2024
medline:
26
9
2024
pubmed:
26
9
2024
entrez:
26
9
2024
Statut:
aheadofprint
Résumé
Head and neck cancer (HNC) treatments often lead to significant morbidity, including lymphedema. This systematic review aims to comprehensively explore the prevalence and impact of head and neck lymphedema (HNL) following treatment. A systematic literature search was conducted up to September 2023. Studies evaluating HNL prevalence, associated factors, impact, patient-reported outcomes (PROMs), and physical assessments were included. Methodological quality assessment was performed, and data were synthesised narratively. Twelve studies met the inclusion criteria, with methodological quality ranging from moderate to high. Internal lymphedema prevalence was consistently higher than external lymphedema, with varying rates attributed to treatment modalities and assessment methods. PROMs such as the Lymphedema Symptom Intensity and Distress-Head and Neck and physical assessments including Patterson's Rating Scale were commonly utilised. HNL significantly impacted quality of life and physical function, with reported symptoms including discomfort, tightness, swallowing difficulties, and psychological distress. HNL is a common sequela of HNC treatment with significant implications for individuals' QoL. Standardised assessment protocols and tailored interventions are needed to address the needs of individuals with HNL and improve overall outcomes. This systematic review highlights a significant prevalence of lymphedema, particularly internal lymphedema in the larynx and pharynx, following treatment. Swallowing difficulties, nutritional issues, anxiety, depression, and body image concerns were associated with both internal and external lymphedema. The impact on quality of life is substantial, with survivors experiencing physical symptoms and psychosocial challenges, emphasising the importance of integrated care approaches tailored to both aspects of well-being.
Identifiants
pubmed: 39325349
doi: 10.1007/s11764-024-01683-3
pii: 10.1007/s11764-024-01683-3
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2024. The Author(s).
Références
Gormley M, et al. Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. Br Dent J. 2022;233(9):780–6.
doi: 10.1038/s41415-022-5166-x
pubmed: 36369568
pmcid: 9652141
Lo Nigro C, et al. Head and neck cancer: improving outcomes with a multidisciplinary approach. Cancer Manag Res. 2017;363-371. https://doi.org/10.2147/CMAR.S115761
Galbiatti ALS, et al. Câncer de cabeça e pescoço: causas, prevenção e tratamento. Braz J Otorhinolaryngol. 2013;79:239–47.
doi: 10.5935/1808-8694.20130041
pubmed: 23670332
Pfister, D.G., et al., Head and neck cancers, version 2.2020, NCCN clinical practice guidelines in oncology. J Natl Compr Cancer Netw. 2020;18(7):873-898.
Fadhil M, et al. Systematic review of head and neck lymphedema assessment. Head & Neck. 2022;44(10):2301–15.
doi: 10.1002/hed.27136
McGarvey A, et al. Lymphoedema following treatment for head and neck cancer: impact on patients, and beliefs of health professionals. Eur J Cancer. 2014;23(3):317–27.
doi: 10.1111/ecc.12134
Ridner SH, et al. A prospective study of the lymphedema and fibrosis continuum in patients with head and neck cancer. Lymphat Res Biol. 2016;14(4):198–205.
doi: 10.1089/lrb.2016.0001
pubmed: 27305456
pmcid: 5178009
Starmer H, et al. Assessment of measures of head and neck lymphedema following head and neck cancer treatment: a systematic review. Lymphat Res Biol. 2023;21(1):42–51.
doi: 10.1089/lrb.2021.0100
pubmed: 35679595
Smith BG, et al. Lymphedema outcomes in patients with head and neck cancer. Otolaryngol Head Neck Surg. 2015;152(2):284–91.
doi: 10.1177/0194599814558402
pubmed: 25389318
Deng J, et al. Prevalence of secondary lymphedema in patients with head and neck cancer. J Pain Symptom Manage. 2012;43(2):244–52.
doi: 10.1016/j.jpainsymman.2011.03.019
pubmed: 21802897
Rhoten BA, Murphy B, Ridner SH. Body image in patients with head and neck cancer: a review of the literature. Oral Oncol. 2013;49(8):753–60.
doi: 10.1016/j.oraloncology.2013.04.005
pubmed: 23683468
Venchiarutti RL, et al. Treatment approaches and outcomes of a head and neck lymphedema service at an Australian comprehensive cancer center. Head & Neck. 2023;45(6):1539–48.
doi: 10.1002/hed.27369
Sharma Y, Mishra G, Parikh V. Quality of life in head and neck cancer patients. Indian J Otolaryngol Head Neck Surg. 2019;71(Suppl 1):927–32.
doi: 10.1007/s12070-019-01620-2
pubmed: 31742096
pmcid: 6848337
Law M, et al. Guidelines for critical review of qualitative studies. McMaster University occupational therapy evidence-based practice research Group. 1998. p 1.
Deng J, et al. Preliminary development of a lymphedema symptom assessment scale for patients with head and neck cancer. Supportive Care in Cancer. 2012;20:1911–8.
doi: 10.1007/s00520-011-1294-6
pubmed: 22072048
Deng J, et al. Differences of symptoms in head and neck cancer patients with and without lymphedema. Supportive Care in Cancer. 2016;24:1305–16.
doi: 10.1007/s00520-015-2893-4
pubmed: 26314703
Pigott A, et al. A prospective observational cohort study examining the development of head and neck lymphedema from the time of diagnosis. Asia Pac J Clin Oncol. 2023;19(4):473–81.
doi: 10.1111/ajco.13843
pubmed: 36101931
Jeans C, et al. Association between external and internal lymphedema and chronic dysphagia following head and neck cancer treatment. Head & Neck. 2021;43(1):255–67.
doi: 10.1002/hed.26484
Jeans C, et al. Comparing the prevalence, location, and severity of head and neck lymphedema after postoperative radiotherapy for oral cavity cancers and definitive chemoradiotherapy for oropharyngeal, laryngeal, and hypopharyngeal cancers. Head & Neck. 2020;42(11):3364–74.
doi: 10.1002/hed.26394
Jeans C, et al. A prospective, longitudinal and exploratory study of head and neck lymphoedema and dysphagia following chemoradiotherapy for head and neck cancer. Dysphagia. 2023;38(4):1059–71.
doi: 10.1007/s00455-022-10526-1
pubmed: 36309604
Deng J, et al. Validity testing of the head and neck lymphedema and fibrosis symptom inventory. Lymphat Res Biol. 2022;20(6):629–39.
doi: 10.1089/lrb.2021.0041
pubmed: 35483066
pmcid: 9810345
Deng J, et al. Impact of secondary lymphedema after head and neck cancer treatment on symptoms, functional status, and quality of life. Head & Neck. 2013;35(7):1026–35.
doi: 10.1002/hed.23084
Schiefke F, et al. Function, postoperative morbidity, and quality of life after cervical sentinel node biopsy and after selective neck dissection. Head & Neck. 2009;31(4):503–12.
doi: 10.1002/hed.21001
Queija DdS, et al. Cervicofacial and pharyngolaryngeal lymphedema and deglutition after head and neck cancer treatment. Dysphagia. 2020;35:479-491.
Deng, J., et al. Refinement and validation of the head and neck lymphedema and fibrosis symptom inventory. Int J Radiat Oncol Biol Phys. 2021;109(3): 747-755.