Maeruines A-E, elusive indole alkaloids from stems of Maerua siamensis and their inhibitory effects on cyclooxygenases and HT-29 colorectal cancer cell proliferation.
Capparaceae
HT-29 cell proliferation
Maerua siamensis
cyclooxygenases
indole alkaloids
Journal
Phytochemistry
ISSN: 1873-3700
Titre abrégé: Phytochemistry
Pays: England
ID NLM: 0151434
Informations de publication
Date de publication:
24 Sep 2024
24 Sep 2024
Historique:
received:
09
06
2024
revised:
19
09
2024
accepted:
23
09
2024
medline:
27
9
2024
pubmed:
27
9
2024
entrez:
26
9
2024
Statut:
aheadofprint
Résumé
Five previously undescribed indole alkaloids, maeruines A-E (1-5), bearing imino-2H-thieno[2,3-b]indol-3(8H)-one skeleton, were obtained from the stems of Maerua siamensis. Their chemical structures were elucidated using spectroscopic techniques [NMR, MS, IR, and UV], and single-crystal X-ray diffraction. Maeruine D (4) displayed selective cyclooxygenase-2 (COX-2) inhibitory activity in vitro with an IC
Identifiants
pubmed: 39326485
pii: S0031-9422(24)00328-5
doi: 10.1016/j.phytochem.2024.114291
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
114291Informations de copyright
Copyright © 2024. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
Declaration of Competing Interest We declare no conflict of interest. Nukulkit, S. and the research project are supported by the Second Century Fund (C2F), Chulalongkorn University (CU), and the Center of Excellence in Natural Products and Nanoparticles, CU. We look forward to hearing from you at your earliest convenience.