TDP-43 nuclear condensation and neurodegenerative proteinopathies.

RNA-binding protein amyotrophic lateral sclerosis frontotemporal dementia membraneless organelles neurodegenerative disease phase condensation

Journal

Trends in neurosciences

ISSN: 1878-108X

Titre abrégé: Trends Neurosci

Pays: England

ID NLM: 7808616

Informations de publication

Date de publication:
25 Sep 2024

Historique:

received: 12 09 2024

accepted: 16 09 2024

medline: 27 9 2024

pubmed: 27 9 2024

entrez: 26 9 2024

Statut: aheadofprint

Résumé

RNA-binding proteins (RBPs) can undergo phase separation and form condensates, processes that, in turn, can be critical for their functionality. In a recent study, Huang, Ellis, and colleagues show that cellular stress can trigger transient alterations in nuclear TAR DNA-binding protein 43 (TDP-43), leading to changes crucial for proper neuronal function. These findings have implications for understanding neurological TDP-43 proteinopathies.

Identifiants

DOI: 10.1016/j.tins.2024.09.003 PMID: 39327159

pubmed: 39327159

pii: S0166-2236(24)00175-9

doi: 10.1016/j.tins.2024.09.003

pii:

doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

Informations de copyright

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.