HPMC-Zein Film-forming Gel Loaded with 5-Fluorouracil Coupled with CO
5-Fluorouracil (5FU)
JAK3 expression
dermabrasion
film-forming gel
vitiligo
Journal
AAPS PharmSciTech
ISSN: 1530-9932
Titre abrégé: AAPS PharmSciTech
Pays: United States
ID NLM: 100960111
Informations de publication
Date de publication:
26 Sep 2024
26 Sep 2024
Historique:
received:
08
07
2024
accepted:
06
09
2024
medline:
27
9
2024
pubmed:
27
9
2024
entrez:
26
9
2024
Statut:
epublish
Résumé
Vitiligo is a significant dermatological challenge affecting 0.5 to 2% of the global population. Despite the various existing medical approaches, current vitiligo treatments are far from ideal. The present study aimed to prepare and evaluate a film-forming gel of 5 fluorouracil (5FU) using different ratios of hydroxypropyl methylcellulose (HPMC) and Zein for treating vitiligo. The prepared film-forming gels were fully characterized in terms of morphology, Fourier-transform infrared spectroscopy, drug content, pH, drying time, in-vitro drug release, and clinical investigation. A 3
Identifiants
pubmed: 39327349
doi: 10.1208/s12249-024-02937-0
pii: 10.1208/s12249-024-02937-0
doi:
Substances chimiques
Fluorouracil
U3P01618RT
Zein
9010-66-6
Hypromellose Derivatives
3NXW29V3WO
Gels
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
225Informations de copyright
© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.
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