Nitroimidazole residues in Egyptian honey using UPLC-Orbitrap-HRMS.

HR-Orbitrap Honey QuEChERS method development method validation nitroimidazoles

Journal

Food additives & contaminants. Part B, Surveillance
ISSN: 1939-3229
Titre abrégé: Food Addit Contam Part B Surveill
Pays: England
ID NLM: 101317183

Informations de publication

Date de publication:
27 Sep 2024
Historique:
medline: 27 9 2024
pubmed: 27 9 2024
entrez: 27 9 2024
Statut: aheadofprint

Résumé

Nitroimidazoles are well-known antibacterial and antiprotozoal agents, effective against various infections. However, they may also exhibit genotoxic, carcinogenic and mutagenic effects. This study aimed to develop an analytical method to quantify nitroimidazole residues and their metabolites in honey using Ultra Performance Liquid Chromatography coupled with Orbitrap High-Resolution Mass Spectrometry (UPLC-Orbitrap-HRMS) and validate it according to Commission Implementing Regulation (EU) 2021/808. The method demonstrated limits of detection (LODs) ranging from 0.01 to 0.17 µg L

Identifiants

DOI: 10.1080/19393210.2024.2405998 PMID: 39328001
pubmed: 39328001
doi: 10.1080/19393210.2024.2405998
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-13

Auteurs

Dina Rabea (D)

Agricultural Research Centre, Ministry of Agriculture and Land Reclamation, Central Laboratory of Residue Analysis of Pesticides and Heavy Metals in Foods, Giza, Egypt.
ORCID: 0009-0009-9678-3989

Lamia Ryad (L)

Agricultural Research Centre, Ministry of Agriculture and Land Reclamation, Central Laboratory of Residue Analysis of Pesticides and Heavy Metals in Foods, Giza, Egypt.

Mohamed R Shehata (MR)

Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt.

Perihan A Khalaf-Alla (PA)

Department of Chemistry, Faculty of Science, University of Cairo, Giza, Egypt.

Classifications MeSH