Immunohistochemistry Markers in Ovarian and Fallopian Tube Neoplasms: a Comprehensive Review.

Differential diagnosis Immunohistochemistry Ovarian cancer Ovary PAX8 WT1 p53

Journal

Indian journal of surgical oncology
ISSN: 0975-7651
Titre abrégé: Indian J Surg Oncol
Pays: India
ID NLM: 101532448

Informations de publication

Date de publication:
Sep 2024
Historique:
received: 09 06 2024
accepted: 22 07 2024
pmc-release: 01 09 2025
medline: 27 9 2024
pubmed: 27 9 2024
entrez: 27 9 2024
Statut: ppublish

Résumé

Immunohistochemistry (IHC) has emerged as a crucial tool in diagnosing and managing ovarian cancer, offering invaluable insights into tumor biology and guiding therapeutic decisions. The intricate histopathological landscape of ovarian cancer presents challenges in accurate diagnosis and classification. IHC offers a complementary approach, aiding in the characterization of tumor subtypes, prognostication, and prediction of treatment response. By targeting specific biomarkers, IHC enables the identification of diverse histological features and molecular alterations associated with ovarian malignancies. The integration of IHC into routine diagnostic workflows enhances diagnostic accuracy, aids in the subclassification of ovarian tumors, and facilitates personalized treatment strategies. Emphasis is placed on the judicious selection of antibody panels tailored to specific clinical scenarios, ensuring optimal utilization of resources and minimizing diagnostic pitfalls. Overall, this review underscores the pivotal role of IHC in refining the diagnosis, prognostication, and management of ovarian cancer, highlighting its significance in the era of precision medicine. By leveraging the molecular insights provided by IHC, clinicians and pathologists can optimize patient care and improve outcomes in ovarian cancer management.

Identifiants

pubmed: 39328739
doi: 10.1007/s13193-024-02049-y
pii: 2049
pmc: PMC11422544
doi:

Types de publication

Journal Article Review

Langues

eng

Pagination

465-480

Informations de copyright

© The Author(s), under exclusive licence to Indian Association of Surgical Oncology 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Déclaration de conflit d'intérêts

Conflict of InterestNone.

Auteurs

Sumedha Gupta (S)

Department of Obstetrics and Gynaecology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Sana Ahuja (S)

Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Dheer Singh Kalwaniya (DS)

Department of Surgery, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India.

Classifications MeSH