TLR4 induced TRPM2 mediated neuropathic pain.
TRPM2 and TLR4
inflammation
lipopolysaccharide reactive oxygen species (ROS)
neuropathic pain
nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (NOX)
Journal
Frontiers in pharmacology
ISSN: 1663-9812
Titre abrégé: Front Pharmacol
Pays: Switzerland
ID NLM: 101548923
Informations de publication
Date de publication:
2024
2024
Historique:
received:
30
07
2024
accepted:
02
09
2024
medline:
27
9
2024
pubmed:
27
9
2024
entrez:
27
9
2024
Statut:
epublish
Résumé
Ion channels play an important role in mediating pain through signal transduction, regulation, and control of responses, particularly in neuropathic pain. Transient receptor potential channel superfamily plays an important role in cation permeability and cellular signaling. Transient receptor potential channel Melastatin 2 (TRPM2) subfamily regulates Ca
Identifiants
pubmed: 39329114
doi: 10.3389/fphar.2024.1472771
pii: 1472771
pmc: PMC11424904
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
1472771Informations de copyright
Copyright © 2024 Mandlem, Rivera, Khan, Quazi and Deba.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.