Let-7f-5p Modulates Lipid Metabolism by Targeting Sterol Regulatory Element-Binding Protein 2 in Response to PRRSV Infection.

PRRSV RNA-seq SREBP2 let-7f-5p lipogenesis

Journal

Veterinary sciences
ISSN: 2306-7381
Titre abrégé: Vet Sci
Pays: Switzerland
ID NLM: 101680127

Informations de publication

Date de publication:
26 Aug 2024
Historique:
received: 03 07 2024
revised: 21 08 2024
accepted: 21 08 2024
medline: 27 9 2024
pubmed: 27 9 2024
entrez: 27 9 2024
Statut: epublish

Résumé

Porcine reproductive and respiratory syndrome (PRRS) has caused substantial damage to the pig industry. MicroRNAs (miRNAs) were found to play crucial roles in modulating the pathogenesis of PRRS virus (PRRSV). In the present study, we revealed that PRRSV induced let-7f-5p to influence lipid metabolism to regulate PRRSV pathogenesis. A transcriptome analysis of PRRSV-infected PK15

Identifiants

DOI: 10.3390/vetsci11090392 PMID: 39330771
pubmed: 39330771
pii: vetsci11090392
doi: 10.3390/vetsci11090392
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : National Natural Science Foundation of China
ID : 31930104 and 32172699

Auteurs

Dongfeng Jiang (D)

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Henan Institute of Pig Biotech Breeding, Zhengzhou 450046, China.

Liyu Yang (L)

College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Henan Institute of Pig Biotech Breeding, Zhengzhou 450046, China.

Xiangge Meng (X)

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.

Qiuliang Xu (Q)

College of Animal Science and Technology, Henan University of Animal Husbandry and Economy, Zhengzhou 450046, China.
Henan Institute of Pig Biotech Breeding, Zhengzhou 450046, China.

Xiang Zhou (X)

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
The Engineering Technology Research Center of Hubei Province Local Pig Breed Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Hubei Hongshan Laboratory, Wuhan 430070, China.

Bang Liu (B)

Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agricultural University, Wuhan 430070, China.
The Engineering Technology Research Center of Hubei Province Local Pig Breed Improvement, Huazhong Agricultural University, Wuhan 430070, China.
Hubei Hongshan Laboratory, Wuhan 430070, China.
ORCID: 0000-0002-3539-6020

Classifications MeSH