Current perspectives and concerns in corneal neurotization.
Journal
Indian journal of ophthalmology
ISSN: 1998-3689
Titre abrégé: Indian J Ophthalmol
Pays: India
ID NLM: 0405376
Informations de publication
Date de publication:
01 Oct 2024
01 Oct 2024
Historique:
received:
19
01
2024
accepted:
17
04
2024
medline:
27
9
2024
pubmed:
27
9
2024
entrez:
27
9
2024
Statut:
ppublish
Résumé
This study aimed to comprehensively explore the intricacies of corneal neurotization (CN) and the nuanced factors that set it apart from routine clinical practice, exerting a substantial influence on its success. A symbiotic relationship is evident between corneal innervation and ocular surface health. The loss of corneal innervation results in a potentially challenging corneal condition known as neurotrophic keratopathy (NK). The majority of treatments are primarily focused on preventing epithelial breakdown rather than addressing the underlying pathogenesis. Consequently, to address the impaired corneal sensation (underlying etiology), a novel surgical approach has emerged, namely CN, which involves transferring healthy sensory nerve axons to the affected cornea. This review offers valuable insights into the existing body of supporting evidence for CN, meticulously examining clinical studies, case reports, and experimental findings. The aim is to enhance our understanding of the effectiveness and potential outcomes associated with this innovative surgical technique. The exploration of innovative therapeutic avenues holds promise for revolutionizing the management of NK, offering a potentially permanent solution to a condition once deemed incurable and severely debilitating.
Identifiants
pubmed: 39331430
doi: 10.4103/IJO.IJO_195_24
pii: 02223307-202472100-00008
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1404-1411Informations de copyright
Copyright © 2024 Copyright: © 2024 Indian Journal of Ophthalmology.
Références
Dua HS, Said DG, Messmer EM, Rolando M, Benitez-Del-Castillo JM, Hossain PN, et al. Neurotrophic keratopathy. Prog Retin Eye Res 2018;66:107–31.
Liu S, Pavan-Langston D, Colby KA. Pediatric herpes simplex of the anterior segment: Characteristics, treatment, and out- comes. Ophthalmology 2012;119:2003–8.
Rosenberg ML. Congenital trigeminal anaesthesia: A review and classification. Brain 1984;107:1073–82.
US Food and Drug Administration. FDA approves first drug for neurotrophic keratitis, a rare eye disease. August 22, 2018. Accessed March 13, 2020. Available from: https://www.fda.gov/news-events/press-announcements/fda-approves-first-drug-neurotrophic-keratitis-rare-eye-disease.
Bonini S, Lambiase A, Rama P, Sinigaglia F, Allegretti M, Chao W, et al. Phase II randomized, double-masked, vehicle-controlled trial of recombinant human nerve growth factor for neurotrophic keratitis. Ophthalmology 2018;125:1332–43.
Pflugfelder SC, Massaro-Giordano M, Perez VL, Hamrah P, Deng SX, Espandar L, et al. Topical recombinant human nerve growth factor (cenegermin) for neurotrophic keratopathy: A multicenter randomized vehicle- controlled pivotal trial. Ophthalmology 2020;127:14–26.
Terzis JK, Dryer MM, Bodner BI. Corneal neurotization: A novel solution to neurotrophic keratopathy. Plast Reconstr Surg 2009;123:112–20.
Leyngold IM, Yen MT, Tian J, Leyngold MM, Vora GK, Weller C. Minimally invasive corneal neurotization with acellular nerve allograft: Surgical technique and clinical outcomes. Ophthalmic Plast Reconstr Surg 2019;35:133–40.
Sweeney AR, Wang M, Weller CL, Burkat C, Kossler AL, Lee BW, et al. Outcomes of corneal neurotisation using processed nerve allografts: A multicentre case series. Br J Ophthalmol 2022;106:326–30.
Gyori E, Tzou CH, Weninger WJ, Reissig L, Schmidt-Erfurth U, Radtke C, et al. Axon numbers and landmarks of trigeminal donor nerves for corneal neurotization. PLoS One 2018;13:e0206642.
Catapano J, Demsey DR, Ho ES, Zuker RM, Borschel GH. Cross-face nerve grafting with infraorbital nerve pathway protection: Anatomic and histomorphometric feasibility study. Plast Reconstr Surg Glob Open 2016;4:e1037.
Janis JE, Hatef DA, Hagan R, Schaub T, Liu JH, Thakar H, et al. Anatomy of the supratrochlear nerve: Implications for the surgical treatment of migraine headaches. Plast Reconstr Surg 2013;131:743–50.
Haładaj R, Polguj M, Topol M. Anatomical variations of the supraorbital and supratrochlear nerves: Their intraorbital course and relation to the supraorbital margin. Med Sci Monit 2019;25:5201–10.
Cuzalina AL, Holmes JD. A simple and reliable landmark for identification of the supraorbital nerve in surgery of the forehead: An in vivo anatomical study. J Oral Maxillofac Surg 2005;63:25–7.
Domeshek LF, Hunter DA, Santosa K, Couch SM, Ali A, Borschel GH, et al. Anatomic characteristics of supraorbital and supratrochlear nerves relevant to their use in corneal neurotization. Eye 2018;33:398–403.
Liu CY, Arteaga AC, Fung SE, Cortina MS, Leyngold IM, Aakalu VK. Corneal neurotization for neurotrophic keratopathy: Review of surgical techniques and outcomes. Ocul Surf 2021;20:163–72.
Elbaz U, Bains R, Zuker RM, Borschel GH, Ali A. Restoration of corneal sensation with regional nerve transfers and nerve grafts: A new approach to a difficult problem. JAMA Ophthalmol 2014;132:1289–95.
Sepehripour S, Lloyd MS, Nishikawa H, Richard B, Parulekar M. Surrogate outcome measures for corneal neurotization in infants and children. J Craniofac Surg 2017;28:1167–70.
Jacinto F, Espana E, Padilla M, Ahmad A, Leyngold I. Ipsilateral supraorbital nerve transfer in a case of recalcitrant neurotrophic keratopathy with an intact ipsilateral frontal nerve: A novel surgical technique. Am J Ophthalmol Case Rep 2016;4:14–7.
Benkhatar H, Levy O, Goemaere I, Borderie V, Laroche L, Bouheraoua N. Corneal neurotization with a great auricular nerve graft: Effective reinnervation demonstrated by in vivo confocal microscopy. Cornea 2018;37:647–50.
Bourcier T, Henrat C, Heitz A, Kremer SF, Labetoulle M, Liverneaux P. Lateral antebrachial cutaneous nerve as autologous graft for mini-invasive corneal neurotization (MICORNE). Cornea 2019;38:1029–32.
Park JK, Charlson ES, Leyngold I, Kossler AL. Corneal neurotization: A review of pathophysiology and outcomes. Ophthalmic Plast Reconstr Surg 2020;36:431–7.
Saini M, Kalia A, Jain AK, Gaba S, Malhotra C, Gupta A, et al. Clinical outcomes of corneal neurotization using sural nerve graft in neurotrophic keratopathy. PLoS One 2023;18:e0294756.
Kim JS, Rafailov L, Leyngold IM. Corneal neurotization for postherpetic neurotrophic keratopathy: Initial experience and clinical outcomes. Ophthalmic Plast Reconstr Surg 2021;37:42–50.
Ting DSJ, Figueiredo GS, Henein C, Barnes E, Ahmed O, Mudhar HS, et al. Corneal neurotization for neurotrophic keratopathy: Clinical outcomes and in vivo confocal microscopic and histopathological findings. Cornea 2018;37:641–6.
Lin CH, Lai LJ. Herpetic corneal keratopathy management using ipsilateral supratrochlear nerve transfer for corneal neurotization. Ann Plast Surg 2019;83:553–7.
Wolkow N, Habib LA, Yoon MK, Freitag SK. Corneal neurotization: Review of a new surgical approach and its developments. Semin Ophthalmol 2019;34:473–87.
Fogagnolo P, Giannaccare G, Bolognesi F, Digiuni M, Tranchina L, Rossetti L, et al. Direct versus indirect corneal neurotization for the treatment of neurotrophic keratopathy: A multicenter prospective comparative study. Am J Ophthalmol 2020;220:203–14.
Fung SSM, Catapano J, Elbaz U, Zuker RM, Borschel GH, Ali A. In vivo confocal microscopy reveals corneal reinnervation after treatment of neurotrophic keratopathy with corneal neurotization. Cornea 2018;37:109–12.
Rosenblatt TR, Sears CM, Park JK, Kossler AL. Corneal neurotization and novel medical therapies for neurotrophic keratopathy. Curr Ophthalmol Rep 2020;8:252–66.
Colen KL, Choi M, Chiu DT. Nerve grafts and conduits. Plast Reconstr Surg 2009;124:e386–94.
Catapano J, Fung SSM, Halliday W, Jobst C, Cheyne D, Ho ES, et al. Treatment of neurotrophic keratopathy with minimally invasive corneal neurotisation: Long-term clinical outcomes and evidence of corneal reinnervation. Br J Ophthalmol 2019;103:1724–31.
Malhotra R, Elalfy MS, Kannan R, Nduka C, Hamada S. Update on corneal neurotisation. Br J Ophthalmol 2019;103:26–35.
Dragnea DC, Krolo I, Koppen C, Faris C, Van den Bogerd B, Ní Dhubhghaill S. Corneal neurotization-indications, surgical techniques and outcomes. J Clin Med 2023;12:2214.
Kauffmann T, Bodanowitz S, Hesse L, Kroll P. Corneal re-innervation after photorefractive keratectomy and laser in situ keratomileusis: An in vivo study with a confocal video- microscope. Ger J Ophthalmol 1996;5:508–12.
Fuchsluger TA, Steuhl KP, Meller D. Neurotrophic keratopathy: A post-LASIK case report [in German]. Klin Monatsbl Augenheilkd 2005;222:901–4.
Gallar J, Acosta MC, Moilanen JAO, Holopainen JM, Belmonte C, Tervo TMT. Recovery of corneal sensitivity to mechanical and chemical stimulation after laser in situ kerato-mileusis. J Refract Surg 2004;20:229–35.
Cruzat A, Qazi Y, Hamrah P. In vivo confocal microscopy of corneal nerves in health and disease. Ocul Surf 2017;15:15–47.
Giannaccare G, Bolognesi F, Biglioli F, Marchetti C, Mariani S, Weiss JS, et al. In vivo and ex vivo comprehensive evaluation of corneal reinnervation in eyes neurotized with contralateral supratrochlear and supraorbital nerves. Cornea 2020;39:210–4.
Allevi F, Fogagnolo P, Rossetti L, Biglioli F. Eyelid reanimation, neurotisation, and transplantation of the cornea in a patient with facial palsy. BMJ Case Rep 2014;2014:bcr2014205372.
Lathrop KL, Duncan K, Yu J, Shah PR, Goldstein J, Nischal KK. Development of corneal sensation with remodeling of the epithelium and the palisades of Vogt after corneal neurotization. Cornea 2020;39:657–60.
Bains RD, Elbaz U, Zuker RM, Ali A, Borschel GH. Corneal neurotization from the supratrochlear nerve with sural nerve grafts: A minimally invasive approach. Plast Reconstr Surg 2015;135:397e–400e.
Catapano J, Antonyshyn K, Zhang JJ, Gordon T, Borschel GH. Corneal neurotization improves ocular surface health in a novel rat model of neurotrophic keratopathy and corneal neurotization. Invest Ophthalmol Vis Sci 2018;59:4345–54.
Belmonte C. Response of sensory units with unmyelinates fibres to mechanical, thermal and chemical stimulation of the cat’s cornea. J Physiol 1993;468:609–22.
Wisely CE, Rafailov L, Cypen S, Proia AD, Boehlke CS, Leyngold IM. Clinical and morphologic outcomes of minimally invasive direct corneal neurotization. OPRS 2020;36:451–7.
Weis E, Rubinov A, Al-ghoul AR, Yau FM. Sural nerve graft for neurotrophic keratitis: early results. Can J Ophthalmol 2018;53:23–8.
Jowett N, Pineda R II. Corneal neurotisation by great auricular nerve transfer and scleral-corneal tunnel incisions for neurotrophic keratopathy. Br J Ophthalmol 2019;103:1235–8.