Catalytic undirected methylation of unactivated C(sp
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
received:
23
04
2024
accepted:
28
08
2024
medline:
28
9
2024
pubmed:
28
9
2024
entrez:
27
9
2024
Statut:
epublish
Résumé
In pharmaceutical discovery, the "magic methyl" effect describes a substantial improvement in the pharmacological properties of a drug candidate with the incorporation of methyl groups. Therefore, to expedite the synthesis of methylated drug analogs, late-stage, undirected methylations of C(sp
Identifiants
pubmed: 39333063
doi: 10.1038/s41467-024-52245-1
pii: 10.1038/s41467-024-52245-1
doi:
Substances chimiques
Nickel
7OV03QG267
Peroxides
0
Biological Products
0
Ligands
0
Terpenes
0
Peptides
0
Carbon
7440-44-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8307Subventions
Organisme : U.S. Department of Health & Human Services | National Institutes of Health (NIH)
ID : R35GM130387
Informations de copyright
© 2024. The Author(s).
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