Post-COVID-19 condition in children: epidemiological evidence stratified by acute disease severity.


Journal

Pediatric research
ISSN: 1530-0447
Titre abrégé: Pediatr Res
Pays: United States
ID NLM: 0100714

Informations de publication

Date de publication:
27 Sep 2024
Historique:
received: 22 02 2024
accepted: 05 09 2024
revised: 18 07 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 27 9 2024
Statut: aheadofprint

Résumé

To determine the prevalence of pediatric Post-COVID-19 condition (PPCC), identify risk factors, and assess the quality of life in children with differing severities of acute COVID-19. During a prospective longitudinal study with a 1-year follow-up, we compared non-hospitalized (mild) and hospitalized (severe) COVID-19 cases to a negatively tested control group. 579 children were included in this study. Of these, 260 had mild acute disease (median age:8, IQR:6-10), 60 had severe acute disease (median age:1, IQR:0.1-4.0), and 259 tested negative for SARS-CoV-2 (NT) (median age:8, IQR:5-10). At three months, 14.6% of the SARS-CoV-2 positive mild group (RR:6.31 (CI 95%: 2.71-14.67)) and 29.2% of the severe group (RR:12.95 (CI 95%: 5.37-31.23)) reported sequelae, versus 2.3% of the NT group. PPCC prevalence in the mild group decreased from 16.1% at one month to 4.4% at one year. Children with PPCC exhibited lower physical health-related quality of life scores and higher fatigue scores than the NT children. Severe acute COVID-19 in children leads to a higher PPCC prevalence than in mild cases. PPCC prevalence decreases over time. Risk factors at three months include prior medical history, hospital admission, and persistent fatigue one month after a positive test. We demonstrate children with severe COVID-19 are more likely to develop Post-COVID-19 condition than those with mild or no infections, and highlights the risk factors. Here we have stratified by acute disease severity, prospectively included a negative control group, and have demonstrated the heterogeneity in prevalence when utilizing various recent definitions of post-COVID. Identifying risk factors for pediatric post-COVID and highlighting the heterogeneity in prevalence based on various current definitions for post-COVID should aid in correctly identifying potential pediatric post-COVID cases, aiding in early intervention.

Sections du résumé

BACKGROUND BACKGROUND
To determine the prevalence of pediatric Post-COVID-19 condition (PPCC), identify risk factors, and assess the quality of life in children with differing severities of acute COVID-19.
METHODS METHODS
During a prospective longitudinal study with a 1-year follow-up, we compared non-hospitalized (mild) and hospitalized (severe) COVID-19 cases to a negatively tested control group.
RESULTS RESULTS
579 children were included in this study. Of these, 260 had mild acute disease (median age:8, IQR:6-10), 60 had severe acute disease (median age:1, IQR:0.1-4.0), and 259 tested negative for SARS-CoV-2 (NT) (median age:8, IQR:5-10). At three months, 14.6% of the SARS-CoV-2 positive mild group (RR:6.31 (CI 95%: 2.71-14.67)) and 29.2% of the severe group (RR:12.95 (CI 95%: 5.37-31.23)) reported sequelae, versus 2.3% of the NT group. PPCC prevalence in the mild group decreased from 16.1% at one month to 4.4% at one year. Children with PPCC exhibited lower physical health-related quality of life scores and higher fatigue scores than the NT children.
CONCLUSIONS CONCLUSIONS
Severe acute COVID-19 in children leads to a higher PPCC prevalence than in mild cases. PPCC prevalence decreases over time. Risk factors at three months include prior medical history, hospital admission, and persistent fatigue one month after a positive test.
IMPACT CONCLUSIONS
We demonstrate children with severe COVID-19 are more likely to develop Post-COVID-19 condition than those with mild or no infections, and highlights the risk factors. Here we have stratified by acute disease severity, prospectively included a negative control group, and have demonstrated the heterogeneity in prevalence when utilizing various recent definitions of post-COVID. Identifying risk factors for pediatric post-COVID and highlighting the heterogeneity in prevalence based on various current definitions for post-COVID should aid in correctly identifying potential pediatric post-COVID cases, aiding in early intervention.

Identifiants

pubmed: 39333387
doi: 10.1038/s41390-024-03597-3
pii: 10.1038/s41390-024-03597-3
doi:

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

© 2024. The Author(s), under exclusive licence to the International Pediatric Research Foundation, Inc.

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Auteurs

Coen R Lap (CR)

Department of Pediatrics - Van Houten research group, Spaarne Gasthuis, Hoofddorp and Haarlem, Haarlem, The Netherlands. c.r.lap@amsterdamumc.nl.
Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands. c.r.lap@amsterdamumc.nl.
Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital and University Medical Centre Utrecht, Utrecht, The Netherlands. c.r.lap@amsterdamumc.nl.

Caroline L H Brackel (CLH)

Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.
Department of Pediatrics, Tergooi Medical Centrum, Hilversum, The Netherlands.

Angelique M A M Winkel (AMAM)

Department of Pediatrics - Van Houten research group, Spaarne Gasthuis, Hoofddorp and Haarlem, Haarlem, The Netherlands.
Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

Simone Hashimoto (S)

Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.
Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam, Amsterdam, The Netherlands.

Milly Haverkort (M)

Department of Infection Prevention and Control, Public Health Service (GGD) Kennemerland, Haarlem, The Netherlands.

Lieke C E Noij (LCE)

Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

Mattijs W Alsem (MW)

Department of Rehabilitation Medicine, Amsterdam Movement Sciences, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

Erik G J von Asmuth (EGJ)

Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands.

Michiel A G E Bannier (MAGE)

Division of Pediatric Respiratory Medicine, Department of Pediatrics, MosaKids Children's Hospital, Maastricht University Medical Centre, Maastricht, The Netherlands.

Emmeline P Buddingh (EP)

Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands.

Johannes B van Goudoever (JB)

Department of Pediatrics, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

Lotte Haverman (L)

Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.
Amsterdam Public Health, Mental Health and Digital Health, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development, Child Development, Amsterdam, The Netherlands.

Anke H Maitland- van der Zee (AHM)

Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.
Department of Pulmonary Medicine, Amsterdam UMC University of Amsterdam, Amsterdam, The Netherlands.

Miriam G Mooij (MG)

Department of Pediatric Nephrology, Sophia Children's Hospital, Erasmus MC, Rotterdam, The Netherlands.

Kim Oostrom (K)

Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

Mariëlle W Pijnenburg (MW)

Division of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC -Sophia Children's Hospital, Rotterdam, The Netherlands.

Sanne Kloosterman (S)

Division of Pediatric Respiratory Medicine and Allergology, Department of Pediatrics, Erasmus MC -Sophia Children's Hospital, Rotterdam, The Netherlands.

Lorynn Teela (L)

Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.
Amsterdam Public Health, Mental Health and Digital Health, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development, Child Development, Amsterdam, The Netherlands.

Michiel Luijten (M)

Child and Adolescent Psychiatry & Psychosocial Care, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.
Amsterdam Public Health, Mental Health and Digital Health, Amsterdam, The Netherlands.
Amsterdam Reproduction and Development, Child Development, Amsterdam, The Netherlands.

Adam J Tulling (AJ)

Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands.

Gertjan Lugthart (G)

Willem Alexander Children's Hospital, Leiden University Medical Centre, Leiden, The Netherlands.

Debby Bogaert (D)

Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital and University Medical Centre Utrecht, Utrecht, The Netherlands.
Centre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK.

Giske Biesbroek (G)

Department of Pediatric Immunology, Rheumatology and Infectious Disease, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

Marlies A van Houten (MA)

Department of Pediatrics - Van Houten research group, Spaarne Gasthuis, Hoofddorp and Haarlem, Haarlem, The Netherlands.

Suzanne W J Terheggen-Lagro (SWJ)

Department of Pediatric Pulmonology and Allergy, Emma Children's Hospital, Amsterdam University Medical Centre (Amsterdam UMC), University of Amsterdam (UvA), Amsterdam, The Netherlands.

Classifications MeSH