36-month durability of ultrasound renal denervation for hypertension resistant to combination therapy in RADIANCE-HTN TRIO.
Hypertension
blood pressure
renal denervation
ultrasound
Journal
Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
received:
10
06
2024
accepted:
25
07
2024
revised:
23
07
2024
medline:
28
9
2024
pubmed:
28
9
2024
entrez:
27
9
2024
Statut:
aheadofprint
Résumé
Endovascular ultrasound renal denervation (uRDN) reduced blood pressure (BP) compared to sham at 2 months in patients with resistant hypertension in the multicenter, blinded, randomized, sham-controlled RADIANCE-HTN TRIO trial. This analysis evaluates longer-term outcomes of patients randomized to uRDN. Patients with resistant hypertension to a 3-drug combination pill were randomized to uRDN (n = 69) or sham (n = 67). From 2-5 months, patients followed a standardized anti-hypertensive medication (AHM) titration protocol. At 6 months, patients were unblinded and received AHM per standard of care. In the uRDN group, 71% (49/69) completed 36-month follow-up. Screening office BP was 159/103 on 3.9 AHM. Baseline office BP on the single-pill combination was 153/99 mmHg. At 36 months, office BP changed by -14.5 ± 26.1/-9.0 ± 14.8 mmHg from screening (p < 0.001 for both) and -8.0 ± 24.5/-5.0 ± 14.6 mmHg from baseline (p = 0.007; p = 0.022) on 3.7 AHM. The efficacy of uRDN was durable to 36 months in patients with resistant hypertension with no safety concerns.
Identifiants
pubmed: 39333663
doi: 10.1038/s41440-024-01854-w
pii: 10.1038/s41440-024-01854-w
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Investigateurs
Yale Wang
(Y)
Nedaa Skeik
(N)
Richard Bae
(R)
Amy McMeans
(A)
JoAnne Goldman
(J)
Rose Peterson
(R)
James Stephen Jenkins
(JS)
Isabelle Tutor
(I)
Michael Harrison
(M)
Angel Penning
(A)
Chandan Devireddy
(C)
Janice Lea
(J)
Amanda Fiebach
(A)
Claudia Merlin
(C)
Florian Rader
(F)
Suhail Dohad
(S)
Anne Tran
(A)
Kirin Bhatia
(K)
Naomi D L Fisher
(NDL)
Piotr Sobieszczyk
(P)
Ian Halliday
(I)
Tay Munson
(T)
Jason Lindsey
(J)
Steven Laster
(S)
Mathew Bunte
(M)
Anthony Hart
(A)
Dana King
(D)
Jamie Hall
(J)
Kintur Sanghvi
(K)
Courtney Krathen
(C)
Luot Lewis
(L)
Ashley Willitts
(A)
Thomas Todoran
(T)
Jan Basile
(J)
Anthony Awkar
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Casey Palmer
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John Schindler
(J)
John Pacella
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Hayder Hashim
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Debbie Cohen
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Informations de copyright
© 2024. The Author(s).
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