The TrkC-PTPσ complex governs synapse maturation and anxiogenic avoidance via synaptic protein phosphorylation.
Avoidance Behavior
Neurotrophin Receptor
Protein Phosphorylation
Social Novelty
Synapse Organizer
Journal
The EMBO journal
ISSN: 1460-2075
Titre abrégé: EMBO J
Pays: England
ID NLM: 8208664
Informations de publication
Date de publication:
27 Sep 2024
27 Sep 2024
Historique:
received:
01
02
2024
accepted:
30
08
2024
revised:
26
08
2024
medline:
28
9
2024
pubmed:
28
9
2024
entrez:
28
9
2024
Statut:
aheadofprint
Résumé
The precise organization of pre- and postsynaptic terminals is crucial for normal synaptic function in the brain. In addition to its canonical role as a neurotrophin-3 receptor tyrosine kinase, postsynaptic TrkC promotes excitatory synapse organization through interaction with presynaptic receptor-type tyrosine phosphatase PTPσ. To isolate the synaptic organizer function of TrkC from its role as a neurotrophin-3 receptor, we generated mice carrying TrkC point mutations that selectively abolish PTPσ binding. The excitatory synapses in mutant mice had abnormal synaptic vesicle clustering and postsynaptic density elongation, more silent synapses, and fewer active synapses, which additionally exhibited enhanced basal transmission with impaired release probability. Alongside these phenotypes, we observed aberrant synaptic protein phosphorylation, but no differences in the neurotrophin signaling pathway. Consistent with reports linking these aberrantly phosphorylated proteins to neuropsychiatric disorders, mutant TrkC knock-in mice displayed impaired social responses and increased avoidance behavior. Thus, through its regulation of synaptic protein phosphorylation, the TrkC-PTPσ complex is crucial for the maturation, but not formation, of excitatory synapses in vivo.
Identifiants
pubmed: 39333774
doi: 10.1038/s44318-024-00252-9
pii: 10.1038/s44318-024-00252-9
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)
ID : RGPIN-2017-04753
Organisme : Canadian Government | Natural Sciences and Engineering Research Council of Canada (NSERC)
ID : RGPIN-2021-03612
Organisme : Canadian Government | Canadian Institutes of Health Research (CIHR)
ID : MOP-133517
Organisme : FRQ | Fonds de Recherche du Québec - Santé (FRQS)
ID : Junior 2 (29106)
Organisme : FRQ | Fonds de Recherche du Québec - Santé (FRQS)
ID : Senior (251655)
Organisme : FRQ | Fonds de Recherche du Québec - Santé (FRQS)
ID : Doctoral scholarship (303256)
Organisme : FRQ | Fonds de Recherche du Québec - Santé (FRQS)
ID : 252652
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP22H02970
Organisme : MEXT | Japan Society for the Promotion of Science (JSPS)
ID : JP21K15314
Organisme : University of Tokushima ()
ID : the Research Cluster program
Organisme : Institut de Recherche Clinique De Montréal (IRCM)
ID : Doctoral and Emmanuel-Triassi scholarships
Organisme : Institut de Recherche Clinique De Montréal (IRCM)
ID : Doctoral scholarship
Organisme : Ministry of Education, Culture, Sports, Science and Technology (MEXT)
ID : HIRAKU-Global Program
Organisme : Société Alzheimer | Alzheimer Society Research Program (ASRP)
ID : Doctoral award
Organisme : Canadian Government | CIHR | Institute of Neurosciences, Mental Health and Addiction (INMHA)
ID : PTJ-191947
Organisme : HHS | NIH | National Institute of Mental Health (NIMH)
ID : R01MH077303
Informations de copyright
© 2024. The Author(s).
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