In Vitro Evaluation of Antipseudomonal Activity and Safety Profile of Peptidomimetic Furin Inhibitors.

Pseudomonas aeruginosa cytochrome P450 3A4 furin inhibitors hepatocytes oxidative stress porcine intestinal cells protein binding

Journal

Biomedicines
ISSN: 2227-9059
Titre abrégé: Biomedicines
Pays: Switzerland
ID NLM: 101691304

Informations de publication

Date de publication:
11 Sep 2024
Historique:
received: 09 08 2024
revised: 06 09 2024
accepted: 10 09 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Inhibitors of the serine protease furin have been widely studied as antimicrobial agents due to their ability to block the cleavage and activation of certain viral surface proteins and bacterial toxins. In this study, the antipseudomonal effects and safety profiles of the furin inhibitors MI-1851 and MI-2415 were assessed. Fluorescence quenching studies suggested no relevant binding of the compounds to human serum albumin and α

Identifiants

DOI: 10.3390/biomedicines12092075 PMID: 39335588
pubmed: 39335588
pii: biomedicines12092075
doi: 10.3390/biomedicines12092075
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : University of Veterinary Medicine
ID : no. RRF-2.3.1-21-2022-00001 and grant No.: SRF-001
Organisme : Recovery and Resilience Facility (RRF), financed under the National Recovery Fund
ID : RRF-2.3.1-21-2022-00001
Organisme : National Research Development and Innovation Office of Hungary
ID : FK146063
Organisme : National Research Development and Innovation Office of Hungary
ID : K134260
Organisme : Hungarian Academy of Sciences: János Bolyai Research Scholarship
ID : RA

Auteurs

Sara Maluck (S)

Department of Pharmacology and Toxicology, University of Veterinary Medicine, Hungary István utca 2, H-1078 Budapest, Hungary.

Rivka Bobrovsky (R)

Department of Pharmacology and Toxicology, University of Veterinary Medicine, Hungary István utca 2, H-1078 Budapest, Hungary.

Miklós Poór (M)

Department of Laboratory Medicine, Medical School, University of Pécs, Ifjúság útja 13, H-7624 Pécs, Hungary.
Molecular Medicine Research Group, János Szentágothai Research Centre, University of Pécs, Ifjúság útja 20, H-7624 Pécs, Hungary.
ORCID: 0000-0003-1425-7459

Roman W Lange (RW)

Department of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032 Marburg, Germany.
ORCID: 0009-0004-7752-6403

Torsten Steinmetzer (T)

Department of Pharmacy, Institute of Pharmaceutical Chemistry, Philipps University, Marbacher Weg 6, 35032 Marburg, Germany.
ORCID: 0000-0001-6523-4754

Ákos Jerzsele (Á)

Department of Pharmacology and Toxicology, University of Veterinary Medicine, Hungary István utca 2, H-1078 Budapest, Hungary.
National Laboratory of Infectious Animal Diseases, Antimicrobial Resistance, Veterinary Public Health and Food Chain Safety, University of Veterinary Medicine, István utca 2, H-1078 Budapest, Hungary.
ORCID: 0000-0002-3380-0827

András Adorján (A)

Department of Microbiology and Infectious Diseases, University of Veterinary Medicine, Hungária krt. 23-25, H-1143 Budapest, Hungary.
ORCID: 0000-0002-2555-6123

Dávid Bajusz (D)

Medicinal Chemistry Research Group and Drug Innovation Centre, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117 Budapest, Hungary.
ORCID: 0000-0003-4277-9481

Anita Rácz (A)

Plasma Chemistry Research Group, HUN-REN Research Centre for Natural Sciences, Magyar tudósok krt. 2, H-1117 Budapest, Hungary.

Erzsébet Pászti-Gere (E)

Department of Pharmacology and Toxicology, University of Veterinary Medicine, Hungary István utca 2, H-1078 Budapest, Hungary.

Classifications MeSH