CD33 and SHP-1/

Alzheimer Disease / genetics Sialic Acid Binding Ig-like Lectin 3 / genetics Humans Protein Tyrosine Phosphatase, Non-Receptor Type 6 / metabolism Microglia / metabolism Genetic Predisposition to Disease Polymorphism, Single Nucleotide
Alzheimer’s disease CD33 SHP-1 microglia

Journal

Genes
ISSN: 2073-4425
Titre abrégé: Genes (Basel)
Pays: Switzerland
ID NLM: 101551097

Informations de publication

Date de publication:
13 Sep 2024
Historique:
received: 01 07 2024
revised: 04 09 2024
accepted: 11 09 2024
medline: 29 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Large-scale genetic studies have identified numerous genetic risk factors that suggest a central role for innate immune cells in susceptibility to Alzheimer's disease (AD). CD33, an immunomodulatory transmembrane sialic acid binding protein expressed on myeloid cells, was identified as one such genetic risk factor associated with Alzheimer's disease. Several studies explored the molecular outcomes of genetic variation at the

Identifiants

DOI: 10.3390/genes15091204 PMID: 39336795
pubmed: 39336795
pii: genes15091204
doi: 10.3390/genes15091204
pii:
doi:

Substances chimiques

Sialic Acid Binding Ig-like Lectin 3 0
Protein Tyrosine Phosphatase, Non-Receptor Type 6 EC 3.1.3.48
CD33 protein, human 0
PTPN6 protein, human EC 3.1.3.48

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : P30AG066462; RF1AG058852;R01AG043617;F30AG074618;T32AI148099; P30AG10161, P30AG72975; R01AG15819; R01AG17917; U01AG46152; and U01AG61356
Pays : United States

Auteurs

Lien Beckers (L)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0003-4625-9811

Mamunur Rashid (M)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
The Carol and Gene Ludwig Center for Research on Neurodegeneration, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0001-6768-1814

Annie J Lee (AJ)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA.

Zena K Chatila (ZK)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
The Carol and Gene Ludwig Center for Research on Neurodegeneration, Columbia University Irving Medical Center, New York, NY 10032, USA.

Kirstin A Tamucci (KA)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
The Carol and Gene Ludwig Center for Research on Neurodegeneration, Columbia University Irving Medical Center, New York, NY 10032, USA.
ORCID: 0000-0002-7033-807X

Ryan C Talcoff (RC)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
The Carol and Gene Ludwig Center for Research on Neurodegeneration, Columbia University Irving Medical Center, New York, NY 10032, USA.

Jennifer L Hall (JL)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
The Carol and Gene Ludwig Center for Research on Neurodegeneration, Columbia University Irving Medical Center, New York, NY 10032, USA.

David A Bennett (DA)

Rush Alzheimer Disease Center, Rush University Medical Center, Chicago, IL 60612, USA.

Badri N Vardarajan (BN)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA.

Elizabeth M Bradshaw (EM)

Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
Division of Translational Neurobiology, Department of Neurology, Columbia University Irving Medical Center, New York, NY 10032, USA.
The Carol and Gene Ludwig Center for Research on Neurodegeneration, Columbia University Irving Medical Center, New York, NY 10032, USA.
The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, New York, NY 10032, USA.
ORCID: 0000-0002-6766-4325

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Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › CD33 and SHP-1/
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Antigènes de différenciation › Antigènes de différenciation des myélomonocytes › Lectine-3 de type Ig liant l'acide sialique › CD33 and SHP-1/
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › CD33 and SHP-1/
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein Tyrosine Phosphatases › SH2 Domain-Containing Protein Tyrosine Phosphatases › Protein Tyrosine Phosphatase, Non-Receptor Type 6 › CD33 and SHP-1/
questionsmedicales.fr › Cellules › Névroglie › Microglie › CD33 and SHP-1/
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › CD33 and SHP-1/
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › CD33 and SHP-1/