Functional Interdependence of Anoctamins May Influence Conclusions from Overexpression Studies.

Humans Anoctamins / metabolism HEK293 Cells Phospholipid Transfer Proteins / metabolism Calcium / metabolism Calcium Signaling Cell Membrane / metabolism
ANO6 Ca2+ signaling TMEM16F anoctamin 6 ion currents phospholipid scrambling

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
17 Sep 2024
Historique:
received: 05 08 2024
revised: 09 09 2024
accepted: 15 09 2024
medline: 29 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Anoctamin 6 (ANO6, TMEM16F) is a phospholipid (PL) scramblase that moves PLs between both plasma membrane (PM) leaflets and operates as an ion channel. It plays a role in development and is essential for hemostasis, bone mineralization and immune defense. However, ANO6 has also been shown to regulate cellular Ca

Identifiants

DOI: 10.3390/ijms25189998 PMID: 39337485
pubmed: 39337485
pii: ijms25189998
doi: 10.3390/ijms25189998
pii:
doi:

Substances chimiques

Anoctamins 0
ANO6 protein, human 0
Phospholipid Transfer Proteins 0
Calcium SY7Q814VUP

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : deutsche forschungsgemeinschaft
ID : Transregio-SFB, Project-ID 509149993, TRR 374 (Project A3).

Auteurs

Jiraporn Ousingsawat (J)

Physiological Institute, University of Regensburg, University Street 31, D-93053 Regensburg, Germany.

Rainer Schreiber (R)

Physiological Institute, University of Regensburg, University Street 31, D-93053 Regensburg, Germany.

Karl Kunzelmann (K)

Physiological Institute, University of Regensburg, University Street 31, D-93053 Regensburg, Germany.
ORCID: 0000-0001-6222-4593

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Functional Interdependence of Anoctamins May...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux chlorure › Anoctamines › Functional Interdependence of Anoctamins May...
questionsmedicales.fr › Cellules › Cellules épithéliales › Cellules HEK293 › Functional Interdependence of Anoctamins May...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transfert des phospholipides › Functional Interdependence of Anoctamins May...
questionsmedicales.fr › Facteurs biologiques › Facteurs de la coagulation sanguine › Calcium › Functional Interdependence of Anoctamins May...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Systèmes de seconds messagers › Signalisation calcique › Functional Interdependence of Anoctamins May...
questionsmedicales.fr › Cellules › Structures cellulaires › Membrane cellulaire › Functional Interdependence of Anoctamins May...