Characterization of Neutrophil Functional Responses to SARS-CoV-2 Infection in a Translational Feline Model for COVID-19.

Animals Cats COVID-19 / immunology Neutrophils / immunology SARS-CoV-2 / physiology Disease Models, Animal Extracellular Traps / immunology Neutrophil Activation Lung / virology Cytokines / metabolism Immunity, Innate Bronchoalveolar Lavage Fluid / immunology
COVID-19 SARS-CoV-2 feline neutrophil neutrophil extracellular traps

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
19 Sep 2024
Historique:
received: 23 08 2024
revised: 13 09 2024
accepted: 17 09 2024
medline: 29 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

There is a complex interplay between viral infection and host innate immune response regarding disease severity and outcomes. Neutrophil hyperactivation, including excessive release of neutrophil extracellular traps (NETs), is linked to exacerbated disease in acute COVID-19, notably in hospitalized patients. Delineating protective versus detrimental neutrophil responses is essential to developing targeted COVID-19 therapies and relies on high-quality translational animal models. In this study, we utilize a previously established feline model for COVID-19 to investigate neutrophil dysfunction in which experimentally infected cats develop clinical disease that mimics acute COVID-19. Specific pathogen-free cats were inoculated with SARS-CoV-2 (B.1.617.2; Delta variant) (

Identifiants

DOI: 10.3390/ijms251810054 PMID: 39337543
pubmed: 39337543
pii: ijms251810054
doi: 10.3390/ijms251810054
pii:
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Institute of General Medical Sciences of the National Institutes of Health
ID : P20GM103648
Organisme : Oklahoma State University
ID : Research Advisory Committee

Auteurs

Sachithra Gunasekara (S)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
ORCID: 0009-0009-9017-2538

Miruthula Tamil Selvan (M)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

Chelsea L Murphy (CL)

Department of Mathematical Sciences, College of Arts and Sciences, Oklahoma State University, Stillwater, OK 74078, USA.
ORCID: 0000-0001-5367-8593

Shoroq Shatnawi (S)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

Shannon Cowan (S)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

Sunil More (S)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

Jerry Ritchey (J)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.

Craig A Miller (CA)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
ORCID: 0000-0002-3638-5665

Jennifer M Rudd (JM)

Department of Veterinary Pathobiology, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK 74078, USA.
ORCID: 0000-0002-4532-3458

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Characterization of Neutrophil Functional...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Carnivora › Feliformia › Felidae › Felis › Chats › Characterization of Neutrophil Functional...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Infections de l'appareil respiratoire › Pneumopathie infectieuse › Pneumopathie virale › COVID-19 › Characterization of Neutrophil Functional...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › Characterization of Neutrophil Functional...
questionsmedicales.fr › Virus › Virus à ARN › Virus à ARN à brin positif › Nidovirales › Coronaviridae › Coronavirus › Betacoronavirus › Virus du SRAS › SARS-CoV-2 › Characterization of Neutrophil Functional...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Characterization of Neutrophil Functional...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace extracellulaire › Pièges extracellulaires › Characterization of Neutrophil Functional...
questionsmedicales.fr › Phénomènes du système immunitaire › Activation des neutrophiles › Characterization of Neutrophil Functional...
questionsmedicales.fr › Appareil respiratoire › Poumon › Characterization of Neutrophil Functional...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Characterization of Neutrophil Functional...
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › Characterization of Neutrophil Functional...
questionsmedicales.fr › Techniques d'investigation › Irrigation thérapeutique › Lavage bronchoalvéolaire › Liquide de lavage bronchoalvéolaire › Characterization of Neutrophil Functional...