RAMP1 Signaling Mitigates Acute Lung Injury by Distinctively Regulating Alveolar and Monocyte-Derived Macrophages.

Animals Acute Lung Injury / metabolism Mice Receptor Activity-Modifying Protein 1 / metabolism Signal Transduction Lipopolysaccharides Macrophages, Alveolar / metabolism Cytokines / metabolism Mice, Inbred C57BL Mice, Knockout Male Macrophages / metabolism Neutrophils / metabolism
RAMP1 immunity macrophage nerve neutrophil

Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
20 Sep 2024
Historique:
received: 08 09 2024
revised: 17 09 2024
accepted: 18 09 2024
medline: 29 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Acute respiratory distress syndrome (ARDS) is a life-threatening lung injury that induces cytokine hypersecretion. Receptor activity-modifying protein (RAMP) 1, a subunit of the calcitonin gene-related peptide (CGRP) receptor, regulates the production of cytokines. This study examined the role of RAMP1 signaling during lipopolysaccharide (LPS)-induced acute lung injury (ALI). LPS administration to wild-type (WT) mice depleted alveolar macrophages (AMs) and recruited monocyte-derived macrophages (MDMs) and neutrophils. RAMP1-deficient (RAMP1

Identifiants

DOI: 10.3390/ijms251810107 PMID: 39337592
pubmed: 39337592
pii: ijms251810107
doi: 10.3390/ijms251810107
pii:
doi:

Substances chimiques

Receptor Activity-Modifying Protein 1 0
Lipopolysaccharides 0
Cytokines 0
Ramp1 protein, mouse 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Auteurs

Atsushi Yamashita (A)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan.
Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
ORCID: 0000-0002-6538-2164

Yoshiya Ito (Y)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan.
Department of Pharmacology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.

Mayuko Osada (M)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan.
Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.

Hiromi Matsuda (H)

Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.

Kanako Hosono (K)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan.
Department of Pharmacology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.

Kazutake Tsujikawa (K)

Laboratory of Molecular and Cellular Physiology, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan.

Hirotsugu Okamoto (H)

Department of Anesthesiology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.

Hideki Amano (H)

Department of Molecular Pharmacology, Graduate School of Medical Sciences, Kitasato University, Sagamihara 252-0373, Japan.
Department of Pharmacology, Kitasato University School of Medicine, Sagamihara 252-0374, Japan.
ORCID: 0000-0001-5014-3462

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies pulmonaires › Lésion pulmonaire aigüe › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines modifiant l'activité des récepteurs › Protéine-1 modifiant l'activité des récepteurs › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Facteurs biologiques › Toxines biologiques › Toxines bactériennes › Endotoxines › Lipopolysaccharides › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › Macrophages alvéolaires › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Macrophages › RAMP1 Signaling Mitigates Acute Lung Injury by...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Phagocytes › Granulocytes neutrophiles › RAMP1 Signaling Mitigates Acute Lung Injury by...