Genomic Landscape of Myelodysplastic/Myeloproliferative Neoplasms: A Multi-Central Study.
Humans
Aged
Male
Female
Middle Aged
Mutation
Myelodysplastic-Myeloproliferative Diseases
/ genetics
Aged, 80 and over
Proto-Oncogene Proteins
/ genetics
Adult
Dioxygenases
Serine-Arginine Splicing Factors
/ genetics
Janus Kinase 2
/ genetics
DNA-Binding Proteins
/ genetics
Genomics
/ methods
Leukemia, Myelomonocytic, Chronic
/ genetics
Myelodysplastic Syndromes
/ genetics
Core Binding Factor Alpha 2 Subunit
/ genetics
Myeloproliferative Disorders
/ genetics
Repressor Proteins
/ genetics
RNA Splicing Factors
/ genetics
Carrier Proteins
Nuclear Proteins
gene mutation
genomic
myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN)
myeloid neoplasm
next-generation sequencing
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
23 Sep 2024
23 Sep 2024
Historique:
received:
18
08
2024
revised:
06
09
2024
accepted:
19
09
2024
medline:
29
9
2024
pubmed:
28
9
2024
entrez:
28
9
2024
Statut:
epublish
Résumé
The accurate diagnosis and classification of myelodysplastic/myeloproliferative neoplasm (MDS/MPN) are challenging due to the overlapping pathological and molecular features of myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN). We investigated the genomic landscape in different MDS/MPN subtypes, including chronic myelomonocytic leukemia (CMML; n = 97), atypical chronic myeloid leukemia (aCML; n = 8), MDS/MPN-unclassified (MDS/MPN-U; n = 44), and MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T; n = 12). Our study indicated that MDS/MPN is characterized by mutations commonly identified in myeloid neoplasms, with
Identifiants
pubmed: 39337700
pii: ijms251810214
doi: 10.3390/ijms251810214
pii:
doi:
Substances chimiques
ASXL1 protein, human
0
Proto-Oncogene Proteins
0
Dioxygenases
EC 1.13.11.-
SRSF2 protein, human
147153-65-9
Serine-Arginine Splicing Factors
170974-22-8
TET2 protein, human
EC 1.13.11.-
Janus Kinase 2
EC 2.7.10.2
DNA-Binding Proteins
0
JAK2 protein, human
EC 2.7.10.2
Core Binding Factor Alpha 2 Subunit
0
Repressor Proteins
0
RNA Splicing Factors
0
SETBP1 protein, human
0
Carrier Proteins
0
Nuclear Proteins
0
Types de publication
Journal Article
Multicenter Study
Langues
eng
Sous-ensembles de citation
IM