Immune Biomarkers at Birth Predict Lower Respiratory Tract Infection Risk in a Large Birth Cohort.

birth cohort cord blood cytokines immune biomarkers lower respiratory tract infection neonates

Journal

Pathogens (Basel, Switzerland)
ISSN: 2076-0817
Titre abrégé: Pathogens
Pays: Switzerland
ID NLM: 101596317

Informations de publication

Date de publication:
05 Sep 2024
Historique:
received: 16 07 2024
revised: 27 08 2024
accepted: 29 08 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

Lower respiratory tract infections (LRTIs) remain the leading cause of infant morbidity and mortality worldwide and affect long-term respiratory health. Identifying immunological determinants of LRTI susceptibility may help stratify disease risk and identify therapies. This study aimed to identify neonatal immunological factors predicting LRTI risk in infancy. Cord blood plasma from 191 neonates from the Boston Birth Cohort was analyzed for 28 soluble immune factors. LRTI was defined as bronchiolitis, bronchitis, or pneumonia during the first year of life. Welch's

Identifiants

DOI: 10.3390/pathogens13090765 PMID: 39338956
pubmed: 39338956
pii: pathogens13090765
doi: 10.3390/pathogens13090765
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Health Resources and Services Administration (HRSA) of the U.S. Department of Health and Hu-man Services (HHS)
ID : UT7MC45949
Organisme : NIH HHS
ID : 2R01HD041702, R01HD098232, R01ES031272, R21AI154233, R01ES031521, U01 ES034983, and K23HD104933
Pays : United States

Auteurs

Ethan Mondell (E)

School of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.
ORCID: 0000-0002-2534-6206

Gustavo Nino (G)

Division of Pulmonary and Sleep Medicine, Children's National Hospital, George Washington University, Washington, DC 20010, USA.
Center for Genetic Medicine Research, Children's Research Institute, Washington, DC 20010, USA.

Xiumei Hong (X)

Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

Xiaobin Wang (X)

Center on the Early Life Origins of Disease, Department of Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
Division of General Pediatrics and Adolescent Medicine, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
ORCID: 0000-0003-4451-302X

Maria J Gutierrez (MJ)

Division of Pediatric Allergy, Immunology and Rheumatology, Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Classifications MeSH