Synergizing Immunotherapy and Antibody-Drug Conjugates: New Horizons in Breast Cancer Therapy.

antibody–drug conjugates (ADCs) breast cancer immunotherapy resistance mechanisms synergistic effects

Journal

Pharmaceutics
ISSN: 1999-4923
Titre abrégé: Pharmaceutics
Pays: Switzerland
ID NLM: 101534003

Informations de publication

Date de publication:
29 Aug 2024
Historique:
received: 13 08 2024
revised: 23 08 2024
accepted: 26 08 2024
medline: 28 9 2024
pubmed: 28 9 2024
entrez: 28 9 2024
Statut: epublish

Résumé

The advent of immunotherapy and antibody-drug conjugates (ADCs) have revolutionized breast cancer treatment, offering new hope to patients. However, challenges, such as resistance and limited efficacy in certain cases, remain. Recently, the combination of these therapies has emerged as a promising approach to address these challenges. ADCs play a crucial role by delivering cytotoxic agents directly to breast cancer cells, minimizing damage to healthy tissue and enhancing the tumor-killing effect. Concurrently, immunotherapies harness the body's immune system to recognize and eliminate cancer cells. This integration offers potential to overcome resistance mechanisms and significantly improve therapeutic outcomes. This review explores the rationale behind combining immunotherapies with ADCs, recent advances in this field, and the potential implications for breast cancer treatment.

Identifiants

pubmed: 39339183
pii: pharmaceutics16091146
doi: 10.3390/pharmaceutics16091146
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Déclaration de conflit d'intérêts

The authors declare no conflicts of interest.

Auteurs

Antonello Pinto (A)

Oncology Unit, "Dario Camberlingo" Hospital, 72021 Francavilla Fontana, Italy.

Chiara Guarini (C)

Oncology Unit, "Dario Camberlingo" Hospital, 72021 Francavilla Fontana, Italy.

Marianna Giampaglia (M)

Oncology Unit, "San Carlo" Hospital, 85100 Potenza, Italy.

Valeria Sanna (V)

Oncology Unit, "Ospedale Civile Santissima Annunziata" Hospital, 07100 Sassari, Italy.

Assunta Melaccio (A)

Oncology Unit, "San Paolo" Hospital, 70123 Bari, Italy.

Laura Lanotte (L)

Oncology Unit, "Mons. Dimiccoli" Hospital, 70051 Barletta, Italy.

Anna Natalizia Santoro (AN)

Oncology Unit, "Dario Camberlingo" Hospital, 72021 Francavilla Fontana, Italy.

Francesca Pini (F)

Oncology Unit, "Dario Camberlingo" Hospital, 72021 Francavilla Fontana, Italy.

Antonio Cusmai (A)

"Don Tonino Bello", I.R.C.C.S. Istituto Tumori "Giovanni Paolo II", 70124 Bari, Italy.

Francesco Giuliani (F)

Oncology Unit, "San Paolo" Hospital, 70123 Bari, Italy.

Gennaro Gadaleta-Caldarola (G)

Oncology Unit, "Mons. Dimiccoli" Hospital, 70051 Barletta, Italy.

Palma Fedele (P)

Oncology Unit, "Dario Camberlingo" Hospital, 72021 Francavilla Fontana, Italy.

Classifications MeSH